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Items: 1 to 20 of 64

1.

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo.

Kawamata H, Peixoto P, Konrad C, Palomo G, Bredvik K, Gerges M, Valsecchi F, Petrucelli L, Ravits JM, Starkov A, Manfredi G.

Mol Neurodegener. 2017 May 8;12(1):37. doi: 10.1186/s13024-017-0180-1.

2.

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.

Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S.

Acta Neuropathol. 2017 Jun;133(6):907-922. doi: 10.1007/s00401-017-1698-6. Epub 2017 Mar 29.

3.

Misfolded SOD1 is not a primary component of sporadic ALS.

Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J.

Acta Neuropathol. 2017 Jul;134(1):97-111. doi: 10.1007/s00401-017-1688-8. Epub 2017 Feb 28.

PMID:
28247063
4.

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.

Williams SM, Khan G, Harris BT, Ravits J, Sierks MR.

BMC Neurosci. 2017 Jan 25;18(1):20. doi: 10.1186/s12868-017-0334-7.

5.

Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).

Grad LI, Rouleau GA, Ravits J, Cashman NR.

Cold Spring Harb Perspect Med. 2017 Aug 1;7(8). pii: a024117. doi: 10.1101/cshperspect.a024117. Review.

PMID:
28003278
6.

Sleep Apnea in Familial Dysautonomia: A Reflection of Apnea Pathogenesis.

Orr JE, Deacon N, Ravits J.

J Clin Sleep Med. 2016 Dec 15;12(12):1583-1584. doi: 10.5664/jcsm.6334. No abstract available.

7.

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.

Braak H, Ludolph AC, Neumann M, Ravits J, Del Tredici K.

Acta Neuropathol. 2017 Jan;133(1):79-90. doi: 10.1007/s00401-016-1633-2. Epub 2016 Oct 18.

8.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.

Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803.

9.

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.

Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW.

Nat Commun. 2016 Jul 5;7:12143. doi: 10.1038/ncomms12143.

10.

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.

Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C.

Neuron. 2016 May 4;90(3):535-50. doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21.

11.

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K.

Acta Neuropathol Commun. 2016 Feb 18;4:15. doi: 10.1186/s40478-016-0286-7.

12.

Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration.

Sellers DL, Bergen JM, Johnson RN, Back H, Ravits JM, Horner PJ, Pun SH.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2514-9. doi: 10.1073/pnas.1515526113. Epub 2016 Feb 17.

13.

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.

Saberi S, Stauffer JE, Schulte DJ, Ravits J.

Neurol Clin. 2015 Nov;33(4):855-76. doi: 10.1016/j.ncl.2015.07.012. Review.

14.

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.

Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, Möller T, Hornstein E.

EMBO J. 2015 Nov 3;34(21):2633-51. doi: 10.15252/embj.201490493. Epub 2015 Sep 1.

15.

Amyotrophic lateral sclerosis: Is the spinal fluid pathway involved in seeding and spread?

Smith R, Myers K, Ravits J, Bowser R.

Med Hypotheses. 2015 Nov;85(5):576-83. doi: 10.1016/j.mehy.2015.07.014. Epub 2015 Jul 20.

16.

A revision of the El Escorial criteria - 2015.

Ludolph A, Drory V, Hardiman O, Nakano I, Ravits J, Robberecht W, Shefner J; WFN Research Group On ALS/MND.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):291-2. doi: 10.3109/21678421.2015.1049183. Epub 2015 Jun 29. No abstract available.

PMID:
26121170
17.

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.

Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A; FALS Sequencing Consortium, Al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB.

Science. 2015 Mar 27;347(6229):1436-41. doi: 10.1126/science.aaa3650. Epub 2015 Feb 19.

18.

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.

Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra RD, Ravits J, Harms MB, Baloh RH.

Ann Neurol. 2015 Jan;77(1):100-13. doi: 10.1002/ana.24306. Epub 2014 Nov 27.

19.

An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.

Gallardo G, Barowski J, Ravits J, Siddique T, Lingrel JB, Robertson J, Steen H, Bonni A.

Nat Neurosci. 2014 Dec;17(12):1710-9. doi: 10.1038/nn.3853. Epub 2014 Oct 26.

20.

Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis.

Ravits J.

Exp Neurol. 2014 Dec;262 Pt B:121-6. doi: 10.1016/j.expneurol.2014.07.021. Epub 2014 Aug 6. Review.

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