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An Optimized Radiosynthesis of [18 F]FNDP, a PET Radiotracer for Imaging Soluble Epoxide Hydrolase (sEH).

Azad BB, Holt DP, Ravert HT, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2018 Mar 12. doi: 10.1002/jlcr.3620. [Epub ahead of print]


Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E.

J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12.


An improved synthesis of the radiolabeled prostate-specific membrane antigen inhibitor, [(18) F]DCFPyL.

Ravert HT, Holt DP, Chen Y, Mease RC, Fan H, Pomper MG, Dannals RF.

J Labelled Comp Radiopharm. 2016 Sep;59(11):439-50. doi: 10.1002/jlcr.3430. Epub 2016 Jul 29.


Synthesis and quality control of [(18) F]T807 for tau PET imaging.

Holt DP, Ravert HT, Dannals RF.

J Labelled Comp Radiopharm. 2016 Aug;59(10):411-5. doi: 10.1002/jlcr.3425. Epub 2016 Jul 17.


Microwave-assisted radiosynthesis of [(18) F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist.

Ravert HT, Holt DP, Gao Y, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2015 Apr;58(4):180-2. doi: 10.1002/jlcr.3275. Epub 2015 Feb 26.


A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.

Ravert HT, Holt DP, Dannals RF.

J Labelled Comp Radiopharm. 2014 Oct;57(12):695-8. doi: 10.1002/jlcr.3241. Epub 2014 Oct 20.


Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice.

Kim J, Horti AG, Mathews WB, Pogorelov V, Valentine H, Brasic JR, Holt DP, Ravert HT, Dannals RF, Zhou L, Jedynak B, Kamiya A, Pletnikov MV, Wong DF.

Mol Imaging Biol. 2015 Jun;17(3):355-63. doi: 10.1007/s11307-014-0786-4.


Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor.

Ravert HT, Dorff P, Foss CA, Mease RC, Fan H, Holmquist CR, Phillips E, McCarthy DJ, Heys JR, Holt DP, Wang Y, Endres CJ, Dannals RF, Pomper MG.

Nucl Med Biol. 2013 Aug;40(6):731-9. doi: 10.1016/j.nucmedbio.2013.04.005. Epub 2013 May 13.


Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography.

Rosenberg PB, Wong DF, Edell SL, Ross JS, Joshi AD, Brašić JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG.

Am J Geriatr Psychiatry. 2013 Mar;21(3):272-8. doi: 10.1016/j.jagp.2012.11.016.


Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.

Horti AG, Ravert HT, Gao Y, Holt DP, Bunnelle WH, Schrimpf MR, Li T, Ji J, Valentine H, Scheffel U, Kuwabara H, Wong DF, Dannals RF.

Nucl Med Biol. 2013 Apr;40(3):395-402. doi: 10.1016/j.nucmedbio.2012.11.013. Epub 2013 Jan 5.


Increased synaptic dopamine in the putamen in restless legs syndrome.

Earley CJ, Kuwabara H, Wong DF, Gamaldo C, Salas RE, Brašić JR, Ravert HT, Dannals RF, Allen RP.

Sleep. 2013 Jan 1;36(1):51-7. doi: 10.5665/sleep.2300.


5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice.

Gao Y, Ravert HT, Valentine H, Scheffel U, Finley P, Wong DF, Dannals RF, Horti AG.

Bioorg Med Chem. 2012 Jun 15;20(12):3698-702. doi: 10.1016/j.bmc.2012.04.056. Epub 2012 May 4.


PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics.

Kuwabara H, Wong DF, Gao Y, Valentine H, Holt DP, Ravert HT, Dannals RF, Horti AG.

J Nucl Med. 2012 Jan;53(1):121-9. doi: 10.2967/jnumed.111.092338. Epub 2011 Dec 15.


Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR).

Potter R, Horti AG, Ravert HT, Holt DP, Finley P, Scheffel U, Dannals RF, Wahl RL.

Bioorg Med Chem. 2011 Apr 1;19(7):2368-72. doi: 10.1016/j.bmc.2011.02.021. Epub 2011 Feb 16.


The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome.

Earley CJ, Kuwabara H, Wong DF, Gamaldo C, Salas R, Brasic J, Ravert HT, Dannals RF, Allen RP.

Sleep. 2011 Mar 1;34(3):341-7.


Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).

Horti AG, Gao Y, Ravert HT, Finley P, Valentine H, Wong DF, Endres CJ, Savonenko AV, Dannals RF.

Bioorg Med Chem. 2010 Jul 15;18(14):5202-7. doi: 10.1016/j.bmc.2010.05.058. Epub 2010 May 25.


In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18).

Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ.

J Nucl Med. 2010 Jun;51(6):913-20. doi: 10.2967/jnumed.109.069088. Erratum in: J Nucl Med. 2010 Aug;51(8):1327.


Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR.

Wong DF, Kuwabara H, Horti AG, Raymont V, Brasic J, Guevara M, Ye W, Dannals RF, Ravert HT, Nandi A, Rahmim A, Ming JE, Grachev I, Roy C, Cascella N.

Neuroimage. 2010 Oct 1;52(4):1505-13. doi: 10.1016/j.neuroimage.2010.04.034. Epub 2010 Apr 18.


Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.

Gao Y, Ravert HT, Kuwabara H, Xiao Y, Endres CJ, Hilton J, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF, Horti AG.

Bioorg Med Chem. 2009 Jul 1;17(13):4367-77. doi: 10.1016/j.bmc.2009.05.021. Epub 2009 May 15.


New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors.

Gao Y, Horti AG, Kuwabara H, Ravert HT, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6168-70. doi: 10.1016/j.bmcl.2008.10.012. Epub 2008 Oct 7.


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