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Items: 1 to 20 of 124

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1.

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC.

Nat Med. 2018 Apr 16. doi: 10.1038/s41591-018-0003-0. [Epub ahead of print]

PMID:
29662201
2.

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway.

Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL.

Cell Rep. 2018 Jan 23;22(4):860-868. doi: 10.1016/j.celrep.2017.12.087. Epub 2018 Jan 28.

3.

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC.

Nat Med. 2018 Feb;24(2):194-202. doi: 10.1038/nm.4464. Epub 2018 Jan 15.

PMID:
29334372
4.

Metabolic Barriers to T Cell Function in Tumors.

Sugiura A, Rathmell JC.

J Immunol. 2018 Jan 15;200(2):400-407. doi: 10.4049/jimmunol.1701041. Review.

PMID:
29311381
5.

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.

Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL.

Cell Metab. 2017 Oct 3;26(4):633-647.e7. doi: 10.1016/j.cmet.2017.09.009.

PMID:
28978427
6.

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW.

Cell Metab. 2017 Oct 3;26(4):648-659.e8. doi: 10.1016/j.cmet.2017.08.017. Epub 2017 Sep 14.

PMID:
28918937
7.

Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate.

MacIver NJ, Rathmell JC.

Curr Opin Immunol. 2017 Jun;46:viii-xi. doi: 10.1016/j.coi.2017.06.002. Epub 2017 Jul 3. No abstract available.

PMID:
28684058
8.

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.

Andrejeva G, Rathmell JC.

Cell Metab. 2017 Jul 5;26(1):49-70. doi: 10.1016/j.cmet.2017.06.004.

PMID:
28683294
9.

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.

Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC.

JCI Insight. 2017 Jun 15;2(12). pii: 93411. doi: 10.1172/jci.insight.93411. [Epub ahead of print]

10.

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.

Olenchock BA, Rathmell JC, Vander Heiden MG.

Immunity. 2017 May 16;46(5):703-713. doi: 10.1016/j.immuni.2017.04.013. Review.

PMID:
28514672
11.

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling.

Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB.

Oncoimmunology. 2017 Mar 20;6(4):e1305535. doi: 10.1080/2162402X.2017.1305535. eCollection 2017.

12.

Dysfunctional T cell metabolism in the tumor microenvironment.

Beckermann KE, Dudzinski SO, Rathmell JC.

Cytokine Growth Factor Rev. 2017 Jun;35:7-14. doi: 10.1016/j.cytogfr.2017.04.003. Epub 2017 Apr 23. Review.

PMID:
28456467
13.

Fine tuning of immunometabolism for the treatment of rheumatic diseases.

Rhoads JP, Major AS, Rathmell JC.

Nat Rev Rheumatol. 2017 May;13(5):313-320. doi: 10.1038/nrrheum.2017.54. Epub 2017 Apr 6. Review.

PMID:
28381829
14.

Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.

Schmidt EA, Fee BE, Henry SC, Nichols AG, Shinohara ML, Rathmell JC, MacIver NJ, Coers J, Ilkayeva OR, Koves TR, Taylor GA.

J Biol Chem. 2017 Mar 17;292(11):4651-4662. doi: 10.1074/jbc.M116.770735. Epub 2017 Feb 1.

15.

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL.

Cell Rep. 2016 Dec 20;17(12):3142-3152. doi: 10.1016/j.celrep.2016.11.065.

16.

Metabolic Signaling Drives IFN-γ.

Siska PJ, Rathmell JC.

Cell Metab. 2016 Nov 8;24(5):651-652. doi: 10.1016/j.cmet.2016.10.018.

17.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC.

Nat Immunol. 2016 Dec;17(12):1459-1466. doi: 10.1038/ni.3577. Epub 2016 Oct 3.

18.

Nutrients and the microenvironment to feed a T cell army.

Johnson MO, Siska PJ, Contreras DC, Rathmell JC.

Semin Immunol. 2016 Oct;28(5):505-513. doi: 10.1016/j.smim.2016.09.003. Epub 2016 Oct 3. Review.

19.

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H.

Immunity. 2016 Sep 20;45(3):540-554. doi: 10.1016/j.immuni.2016.08.017. Epub 2016 Sep 13.

20.

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.

Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC.

J Immunol Methods. 2016 Nov;438:51-58. doi: 10.1016/j.jim.2016.08.013. Epub 2016 Sep 2.

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