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Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption.

Maura D, Rahme LG.

Antimicrob Agents Chemother. 2017 Sep 18. pii: AAC.01362-17. doi: 10.1128/AAC.01362-17. [Epub ahead of print]


NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone.

Bandyopadhaya A, Tsurumi A, Rahme LG.

Front Microbiol. 2017 Jun 30;8:1211. doi: 10.3389/fmicb.2017.01211. eCollection 2017.


Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance.

Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Déziel E, Zahler R, Pucci M, Felici A, Fetzner S, Lépine F, Rahme LG.

ACS Chem Biol. 2017 May 19;12(5):1435-1443. doi: 10.1021/acschembio.6b01139. Epub 2017 Apr 12.


Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR Jr, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB.

MBio. 2017 Mar 21;8(2). pii: e00186-17. doi: 10.1128/mBio.00186-17.


Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition.

Turnpenny P, Padfield A, Barton P, Teague J, Rahme LG, Pucci MJ, Zahler R, Rubio A.

J Pharm Biomed Anal. 2017 May 30;139:44-53. doi: 10.1016/j.jpba.2017.02.034. Epub 2017 Feb 28.


TNF-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections.

Tsurumi A, Que YA, Ryan CM, Tompkins RG, Rahme LG.

Front Public Health. 2016 Oct 5;4:216. eCollection 2016.


Considerations and caveats in anti-virulence drug development.

Maura D, Ballok AE, Rahme LG.

Curr Opin Microbiol. 2016 Oct;33:41-46. doi: 10.1016/j.mib.2016.06.001. Epub 2016 Jun 16. Review.


A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming.

Bandyopadhaya A, Tsurumi A, Maura D, Jeffrey KL, Rahme LG.

Nat Microbiol. 2016 Oct 3;1:16174. doi: 10.1038/nmicrobiol.2016.174.


Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR.

Maura D, Hazan R, Kitao T, Ballok AE, Rahme LG.

Sci Rep. 2016 Sep 28;6:34083. doi: 10.1038/srep34083.


Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa.

Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS.

ACS Chem Biol. 2016 Nov 18;11(11):3061-3067. Epub 2016 Sep 22.


Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle.

Bandyopadhaya A, Constantinou C, Psychogios N, Ueki R, Yasuhara S, Martyn JA, Wilhelmy J, Mindrinos M, Rahme LG, Tzika AA.

Int J Mol Med. 2016 Apr;37(4):867-78. doi: 10.3892/ijmm.2016.2487. Epub 2016 Feb 12.


Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance.

Hazan R, Que YA, Maura D, Strobel B, Majcherczyk PA, Hopper LR, Wilbur DJ, Hreha TN, Barquera B, Rahme LG.

Curr Biol. 2016 Jan 25;26(2):195-206. doi: 10.1016/j.cub.2015.11.056. Epub 2016 Jan 14.


In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.

Constantinou C, Apidianakis Y, Psychogios N, Righi V, Mindrinos MN, Khan N, Swartz HM, Szeto HH, Tompkins RG, Rahme LG, Tzika AA.

Int J Mol Med. 2016 Feb;37(2):299-308. doi: 10.3892/ijmm.2015.2426. Epub 2015 Dec 8.


Do standard burn mortality formulae work on a population of severely burned children and adults?

Tsurumi A, Que YA, Yan S, Tompkins RG, Rahme LG, Ryan CM.

Burns. 2015 Aug;41(5):935-45. doi: 10.1016/j.burns.2015.03.017. Epub 2015 Apr 25.


Prediction of multiple infections after severe burn trauma: a prospective cohort study.

Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG.

Ann Surg. 2015 Apr;261(4):781-92. doi: 10.1097/SLA.0000000000000759.


Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.

Hazan R, Maura D, Que YA, Rahme LG.

Methods Mol Biol. 2014;1149:699-707. doi: 10.1007/978-1-4939-0473-0_54.


Assessing Pseudomonas virulence with the nonmammalian host model: Arabidopsis thaliana.

Baldini RL, Starkey M, Rahme LG.

Methods Mol Biol. 2014;1149:689-97. doi: 10.1007/978-1-4939-0473-0_53.


In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.

Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA.

Int J Mol Med. 2014 Jul;34(1):327-33. doi: 10.3892/ijmm.2014.1757. Epub 2014 Apr 24.


Live-cell high resolution magic angle spinning magnetic resonance spectroscopy for in vivo analysis of Pseudomonas aeruginosa metabolomics.

Righi V, Constantinou C, Kesarwani M, Rahme LG, Tzika AA.

Biomed Rep. 2013 Sep;1(5):707-712. Epub 2013 Jul 22.


A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria.

Que YA, Hazan R, Strobel B, Maura D, He J, Kesarwani M, Panopoulos P, Tsurumi A, Giddey M, Wilhelmy J, Mindrinos MN, Rahme LG.

PLoS One. 2013 Dec 19;8(12):e80140. doi: 10.1371/journal.pone.0080140. eCollection 2013.

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