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Page 1
The avian proghrelin system.
Richards MP, McMurtry JP. Richards MP, et al. Int J Pept. 2010;2010:749401. doi: 10.1155/2010/749401. Epub 2010 Feb 10. Int J Pept. 2010. PMID: 20798876 Free PMC article.
These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different …
These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obest …
On the processing of proghrelin to ghrelin.
Zhu X, Cao Y, Voogd K, Steiner DF. Zhu X, et al. J Biol Chem. 2006 Dec 15;281(50):38867-70. doi: 10.1074/jbc.M607955200. Epub 2006 Oct 18. J Biol Chem. 2006. PMID: 17050541 Free article.
In this report, we have studied the endoproteolytic processing of this molecule from its precursor (proghrelin) into mature ghrelin in various prohormone convertase null mouse strains generated in our laboratory and have identified the convertase responsible for this event …
In this report, we have studied the endoproteolytic processing of this molecule from its precursor (proghrelin) into mature ghrelin i …
Characterisation of proghrelin peptides in mammalian tissue and plasma.
Bang AS, Soule SG, Yandle TG, Richards AM, Pemberton CJ. Bang AS, et al. J Endocrinol. 2007 Feb;192(2):313-23. doi: 10.1677/JOE-06-0021. J Endocrinol. 2007. PMID: 17283231 Clinical Trial.
Ghrelin is a 28 amino acid stomach peptide, derived from proghrelin(1-94), that stimulates GH release, appetite and adipose deposition. ...Rather, our data suggest that circulating and stored peptides derived from the carboxyl terminal of proghrelin (C-ghrelin) are …
Ghrelin is a 28 amino acid stomach peptide, derived from proghrelin(1-94), that stimulates GH release, appetite and adipose depositio …
Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas.
Qader SS, Håkanson R, Rehfeld JF, Lundquist I, Salehi A. Qader SS, et al. Regul Pept. 2008 Feb 7;146(1-3):230-7. doi: 10.1016/j.regpep.2007.09.017. Epub 2007 Sep 18. Regul Pept. 2008. PMID: 17942170
Proghrelin, the precursor of the orexigenic and adipogenic peptide hormone ghrelin, is synthetized in endocrine (A-like) cells in the gastric mucosa. ...This study examines the effects of the proghrelin products, alone and in combinations, on the secretion of insuli …
Proghrelin, the precursor of the orexigenic and adipogenic peptide hormone ghrelin, is synthetized in endocrine (A-like) cells in the …
Regulation of food intake and body weight by recombinant proghrelin.
Zhang W, Majumder A, Wu X, Mulholland MW. Zhang W, et al. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1269-75. doi: 10.1152/ajpendo.00337.2009. Epub 2009 Sep 29. Am J Physiol Endocrinol Metab. 2009. PMID: 19789292 Free PMC article.
Ghrelin is a 28-amino-acid hormone derived from the endoproteolytic processing of its prehormone proghrelin. Although ghrelin has been reported to regulate food intake and body weight, it is still unknown whether proghrelin exercises any biological function. ...Reco …
Ghrelin is a 28-amino-acid hormone derived from the endoproteolytic processing of its prehormone proghrelin. Although ghrelin has bee …
Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets.
Kumar R, Salehi A, Rehfeld JF, Höglund P, Lindström E, Håkanson R. Kumar R, et al. Regul Pept. 2010 Sep 24;164(2-3):65-70. doi: 10.1016/j.regpep.2010.06.005. Epub 2010 Jul 6. Regul Pept. 2010. PMID: 20619300
BACKGROUND: Proghrelin, produced by the ghrelin (A-like) cells of the gastric mucosa, gives rise to cleavage products, including desacyl ghrelin, acyl ghrelin and obestatin. ...
BACKGROUND: Proghrelin, produced by the ghrelin (A-like) cells of the gastric mucosa, gives rise to cleavage products, including desa …
Biochemistry of ghrelin precursor peptides.
Pemberton CJ, Richards AM. Pemberton CJ, et al. Vitam Horm. 2008;77:13-30. doi: 10.1016/S0083-6729(06)77002-9. Vitam Horm. 2008. PMID: 17983851 Review.
Since its discovery in 1999, the stomach-derived hormone ghrelin has been studied intensively. Proghrelin is 94 amino acids long in mammals and this undergoes proteolytic processing to produce ghrelin [residues 1-28 of proghrelin(1-94)] and the C-terminal peptide C- …
Since its discovery in 1999, the stomach-derived hormone ghrelin has been studied intensively. Proghrelin is 94 amino acids long in m …
PCSK1 Variants and Human Obesity.
Ramos-Molina B, Martin MG, Lindberg I. Ramos-Molina B, et al. Prog Mol Biol Transl Sci. 2016;140:47-74. doi: 10.1016/bs.pmbts.2015.12.001. Epub 2016 Jan 29. Prog Mol Biol Transl Sci. 2016. PMID: 27288825 Free PMC article. Review.
PC1/3 activity is essential for the activating cleavage of many peptide hormone precursors implicated in the regulation of food ingestion, glucose homeostasis, and energy homeostasis, for example, proopiomelanocortin, proinsulin, proglucagon, and proghrelin. A large number …
PC1/3 activity is essential for the activating cleavage of many peptide hormone precursors implicated in the regulation of food ingestion, g …
Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide.
Jeffery PL, Duncan RP, Yeh AH, Jaskolski RA, Hammond DS, Herington AC, Chopin LK. Jeffery PL, et al. Endocrinology. 2005 Jan;146(1):432-40. doi: 10.1210/en.2003-1466. Epub 2004 Oct 7. Endocrinology. 2005. PMID: 15471962
Immunohistochemistry, employing antibodies raised against the mature human n-octanoylated ghrelin peptide and the putative C-terminal peptide encoded by the exon 4-deleted proghrelin variant, was used to demonstrate protein expression of ghrelin and the variant in multiple …
Immunohistochemistry, employing antibodies raised against the mature human n-octanoylated ghrelin peptide and the putative C-terminal peptid …
Ghrelin acylation and metabolic control.
Al Massadi O, Tschöp MH, Tong J. Al Massadi O, et al. Peptides. 2011 Nov;32(11):2301-8. doi: 10.1016/j.peptides.2011.08.020. Epub 2011 Aug 27. Peptides. 2011. PMID: 21893140 Review.
Ghrelin acylation is dependent on the function of GOAT and the availability of substrates such as proghrelin and short- to medium-chain fatty acids (MCFAs). This process is governed by GOAT activity and has been shown to be modified by dietary lipids. ...
Ghrelin acylation is dependent on the function of GOAT and the availability of substrates such as proghrelin and short- to medium-cha …
52 results