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Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.

McConnell EV, Bruzual I, Pou S, Winter R, Dodean RA, Smilkstein MJ, Krollenbrock A, Nilsen A, Zakharov LN, Riscoe MK, Doggett JS.

ACS Infect Dis. 2018 Aug 30. doi: 10.1021/acsinfecdis.8b00133. [Epub ahead of print]


Human enteric viruses in a wastewater treatment plant: evaluation of activated sludge combined with UV disinfection process reveals different removal performances for viruses with different features.

Lizasoain A, Tort LFL, García M, Gillman L, Alberti A, Leite JPG, Miagostovich MP, Pou SA, Cagiao A, Razsap A, Huertas J, Berois M, Victoria M, Colina R.

Lett Appl Microbiol. 2018 Mar;66(3):215-221. doi: 10.1111/lam.12839. Epub 2018 Feb 6.


Proinflammatory Dietary Intake is Associated with Increased Risk of Colorectal Cancer: Results of a Case-Control Study in Argentina Using a Multilevel Modeling Approach.

Niclis C, Pou SA, Shivappa N, Hébert JR, Steck SE, Díaz MDP.

Nutr Cancer. 2018 Jan;70(1):61-68. doi: 10.1080/01635581.2018.1397710. Epub 2017 Nov 15.


Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.

Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK.

ACS Infect Dis. 2017 Oct 13;3(10):728-735. doi: 10.1021/acsinfecdis.7b00062. Epub 2017 Sep 27.


[Inequities in health: socio-demographic and spatial analysis of breast cancer in women from Córdoba, Argentina].

Tumas N, Pou SA, Díaz MDP.

Gac Sanit. 2017 Sep - Oct;31(5):396-403. doi: 10.1016/j.gaceta.2016.12.011. Epub 2017 Mar 18. Spanish.


Burden of cancer mortality and differences attributable to demographic aging and risk factors in Argentina, 1986-2011.

Pou SA, Tumas N, Coquet JB, Niclis C, Román MD, Díaz MD.

Cad Saude Publica. 2017 Mar 9;33(2):e00016616. doi: 10.1590/0102-311X00016616.


Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii.

Alday PH, Bruzual I, Nilsen A, Pou S, Winter R, Ben Mamoun C, Riscoe MK, Doggett JS.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01866-16. doi: 10.1128/AAC.01866-16. Print 2017 Feb.


Identification of dietary patterns in urban population of Argentina: study on diet-obesity relation in population-based prevalence study.

Pou SA, Del Pilar Díaz M, De La Quintana AG, Forte CA, Aballay LR.

Nutr Res Pract. 2016 Dec;10(6):616-622. Epub 2016 Sep 26.


Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.

Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE.

ACS Infect Dis. 2016 Jul 8;2(7):500-8. doi: 10.1021/acsinfecdis.6b00052. Epub 2016 May 13.


Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone.

Lawres LA, Garg A, Kumar V, Bruzual I, Forquer IP, Renard I, Virji AZ, Boulard P, Rodriguez EX, Allen AJ, Pou S, Wegmann KW, Winter RW, Nilsen A, Mao J, Preston DA, Belperron AA, Bockenstedt LK, Hinrichs DJ, Riscoe MK, Doggett JS, Ben Mamoun C.

J Exp Med. 2016 Jun 27;213(7):1307-18. doi: 10.1084/jem.20151519. Epub 2016 Jun 6.


Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.

Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4853-9. doi: 10.1128/AAC.00791-16. Print 2016 Aug.


ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, Kim K, Zakharov LN, Donini C, Burrows JN, Vaidya AB, Charman SA, Riscoe MK.

Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60. doi: 10.1128/AAC.01183-15. Epub 2015 Jun 29.


Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.

Am J Trop Med Hyg. 2015 Jun;92(6):1195-201. doi: 10.4269/ajtmh.14-0553. Epub 2015 Apr 27.


Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.


[Cancer and its association with dietary patterns in Córdoba (Argentina)].

Pou SA, Niclis C, Aballay LR, Tumas N, Román MD, Muñoz SE, Coquet JB, Díaz Mdel P.

Nutr Hosp. 2014 Mar 1;29(3):618-28. doi: 10.3305/nh.2014.29.3.7192. Spanish.


Dietary patterns and risk of urinary tract tumors: a multilevel analysis of individuals in rural and urban contexts.

Pou SA, Niclis C, Eynard AR, Díaz Mdel P.

Eur J Nutr. 2014 Aug;53(5):1247-53. doi: 10.1007/s00394-013-0627-2. Epub 2013 Nov 29.


Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.

Kondo MA, Tajinda K, Colantuoni C, Hiyama H, Seshadri S, Huang B, Pou S, Furukori K, Hookway C, Jaaro-Peled H, Kano SI, Matsuoka N, Harada K, Ni K, Pevsner J, Sawa A.

Transl Psychiatry. 2013 Apr 2;3:e243. doi: 10.1038/tp.2013.19.


Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.

Pou S, Winter RW, Nilsen A, Kelly JX, Li Y, Doggett JS, Riscoe EW, Wegmann KW, Hinrichs DJ, Riscoe MK.

Antimicrob Agents Chemother. 2012 Jul;56(7):3475-80. doi: 10.1128/AAC.00100-12. Epub 2012 Apr 16.


Applying multilevel model to the relationship of dietary patterns and colorectal cancer: an ongoing case-control study in Córdoba, Argentina.

Pou SA, Díaz Mdel P, Osella AR.

Eur J Nutr. 2012 Sep;51(6):755-64. doi: 10.1007/s00394-011-0255-7. Epub 2011 Oct 12.


Prostate cancer mortality trends in Argentina 1986-2006: an age-period-cohort and joinpoint analysis.

Niclis C, Pou SA, Bengió RH, Osella AR, Díaz Mdel P.

Cad Saude Publica. 2011 Jan;27(1):123-30.

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