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Items: 1 to 20 of 205

1.

The use of molecular descriptors in the development of co-amorphous formulations.

Meng-Lund H, Kasten G, Jensen KT, Poso A, Pantsar T, Rades T, Rantanen J, Grohganz H.

Eur J Pharm Sci. 2018 Jul 1;119:31-38. doi: 10.1016/j.ejps.2018.04.014. Epub 2018 Apr 10.

PMID:
29649569
2.

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa.

McVey AC, Medarametla P, Chee X, Bartlett S, Poso A, Spring DR, Rahman T, Welch M.

Biochemistry. 2017 Oct 17;56(41):5539-5549. doi: 10.1021/acs.biochem.7b00852. Epub 2017 Oct 6.

PMID:
28985053
3.

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.

Välimäki MJ, Tölli MA, Kinnunen SM, Aro J, Serpi R, Pohjolainen L, Talman V, Poso A, Ruskoaho HJ.

J Med Chem. 2017 Sep 28;60(18):7781-7798. doi: 10.1021/acs.jmedchem.7b00816. Epub 2017 Sep 15.

PMID:
28858485
4.

Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.

Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT.

Eur J Pharm Sci. 2017 Sep 30;107:97-111. doi: 10.1016/j.ejps.2017.07.002. Epub 2017 Jul 5.

PMID:
28687529
5.

Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data.

Kaupang Å, Laitinen T, Poso A, Hansen TV.

Proteins. 2017 Sep;85(9):1684-1698. doi: 10.1002/prot.25325. Epub 2017 Jun 23.

PMID:
28543443
6.

Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme.

Meng-Lund H, Friis N, van de Weert M, Rantanen J, Poso A, Grohganz H, Jorgensen L.

Int J Pharm. 2017 May 15;523(1):238-245. doi: 10.1016/j.ijpharm.2017.03.043. Epub 2017 Mar 21.

PMID:
28336459
7.

Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery.

Christensen JR, Meng-Lund H, Grohganz H, Poso A, Laitinen T, Korhonen O, Jørgensen L, Pajander J.

Eur J Pharm Sci. 2017 May 1;102:188-195. doi: 10.1016/j.ejps.2017.03.013. Epub 2017 Mar 12.

PMID:
28300611
8.

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining.

Haidar S, Bouaziz Z, Marminon C, Laitinen T, Poso A, Le Borgne M, Jose J.

Pharmaceuticals (Basel). 2017 Jan 9;10(1). pii: E8. doi: 10.3390/ph10010008.

9.

Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.

Asquith CR, Konstantinova LS, Laitinen T, Meli ML, Poso A, Rakitin OA, Hofmann-Lehmann R, Hilton ST.

ChemMedChem. 2016 Oct 6;11(19):2119-2126. doi: 10.1002/cmdc.201600260. Epub 2016 Aug 11.

PMID:
27511289
10.

Virtual Screening of Small Drug-Like Compounds Stimulating the Enzymatic Activity of Kallikrein-Related Peptidase 3 (KLK3).

Ylikangas H, Mattsson JM, Stenman UH, Koistinen H, Poso A, Lahtela-Kakkonen M.

ChemMedChem. 2016 Sep 20;11(18):2043-9. doi: 10.1002/cmdc.201600181. Epub 2016 Jul 28.

PMID:
27465435
11.

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L.

Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23.

PMID:
27213815
12.

Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics.

Kaczor AA, Silva AG, Loza MI, Kolb P, Castro M, Poso A.

ChemMedChem. 2016 Apr 5;11(7):718-29. doi: 10.1002/cmdc.201500599. Epub 2016 Mar 18.

PMID:
26990027
13.

The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs.

Kuosmanen SM, Viitala S, Laitinen T, Peräkylä M, Pölönen P, Kansanen E, Leinonen H, Raju S, Wienecke-Baldacchino A, Närvänen A, Poso A, Heinäniemi M, Heikkinen S, Levonen AL.

Nucleic Acids Res. 2016 Feb 29;44(4):1760-75. doi: 10.1093/nar/gkw052. Epub 2016 Jan 29.

14.

Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes.

Raunio H, Juvonen RO, Poso A, Lahtela-Kakkonen M, Rahnasto-Rilla M.

Drug Metab Lett. 2016;10(1):56-64.

PMID:
26648056
15.

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.

Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ.

Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2.

PMID:
26575458
16.

Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.

Salminen KA, Rahnasto-Rilla M, Väänänen R, Imming P, Meyer A, Horling A, Poso A, Laitinen T, Raunio H, Lahtela-Kakkonen M.

Drug Metab Dispos. 2015 Dec;43(12):1891-904. doi: 10.1124/dmd.115.065755. Epub 2015 Sep 23.

17.

Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors.

Kaczor AA, Targowska-Duda KM, Patel JZ, Laitinen T, Parkkari T, Adams Y, Nevalainen TJ, Poso A.

J Mol Model. 2015 Oct;21(10):250. doi: 10.1007/s00894-015-2789-8. Epub 2015 Sep 8.

18.

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.

Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13.

PMID:
26165838
19.

Virtual screening approach of sirtuin inhibitors results in two new scaffolds.

Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela-Kakkonen M.

Eur J Pharm Sci. 2015 Aug 30;76:27-32. doi: 10.1016/j.ejps.2015.04.025. Epub 2015 May 1.

PMID:
25936698
20.

Multi-Component Protein - Protein Docking Based Protocol with External Scoring for Modeling Dimers of G Protein-Coupled Receptors.

Kaczor AA, Guixà-González R, Carrió P, Poso A, Dove S, Pastor M, Selent J.

Mol Inform. 2015 Apr;34(4):246-55. doi: 10.1002/minf.201400088. Epub 2015 Mar 27.

PMID:
27490170

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