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Items: 1 to 20 of 190

1.

Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS.

Dantas LS, Chaves-Filho AB, Coelho FR, Genaro-Mattos TC, Tallman KA, Porter NA, Augusto O, Miyamoto S.

Redox Biol. 2018 Aug 16;19:105-115. doi: 10.1016/j.redox.2018.08.007. [Epub ahead of print]

2.

Identification and Characterization of Prescription Drugs that Change Levels of the Cholesterol Precursors 7-Dehydrocholesterol and Desmosterol.

Wages PA, Kim HH, Korade Z, Porter NA.

J Lipid Res. 2018 Aug 7. pii: jlr.M086991. doi: 10.1194/jlr.M086991. [Epub ahead of print]

3.

Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis.

Genaro-Mattos TC, Tallman KA, Allen LB, Anderson A, Mirnics K, Korade Z, Porter NA.

Toxicol Appl Pharmacol. 2018 Jun 15;349:21-28. doi: 10.1016/j.taap.2018.04.029. Epub 2018 Apr 23.

PMID:
29698737
4.

Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin.

Joseph AI, Edwards RL, Luis PB, Presley SH, Porter NA, Schneider C.

Org Biomol Chem. 2018 May 2;16(17):3273-3281. doi: 10.1039/c8ob00639c.

PMID:
29664496
5.

Correction to A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs.

Sun R, Shi F, Liu K, Fu L, Tian C, Yang Y, Tallman KA, Porter NA, Yang J.

Chem Res Toxicol. 2017 Nov 20;30(11):2093. doi: 10.1021/acs.chemrestox.7b00297. Epub 2017 Nov 7. No abstract available.

PMID:
29111684
6.

Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure.

Korade Z, Genaro-Mattos TC, Tallman KA, Liu W, Garbett KA, Koczok K, Balogh I, Mirnics K, Porter NA.

J Lipid Res. 2017 Nov;58(11):2139-2146. doi: 10.1194/jlr.M079475. Epub 2017 Sep 28.

PMID:
28972118
7.

A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs.

Sun R, Shi F, Liu K, Fu L, Tian C, Yang Y, Tallman KA, Porter NA, Yang J.

Chem Res Toxicol. 2017 Oct 16;30(10):1797-1803. doi: 10.1021/acs.chemrestox.7b00183. Epub 2017 Oct 6. Erratum in: Chem Res Toxicol. 2017 Nov 20;30(11):2093.

PMID:
28960974
8.

Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes.

Fu L, Liu K, Sun M, Tian C, Sun R, Morales Betanzos C, Tallman KA, Porter NA, Yang Y, Guo D, Liebler DC, Yang J.

Mol Cell Proteomics. 2017 Oct;16(10):1815-1828. doi: 10.1074/mcp.RA117.000108. Epub 2017 Aug 21.

PMID:
28827280
9.

Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.

Sun R, Fu L, Liu K, Tian C, Yang Y, Tallman KA, Porter NA, Liebler DC, Yang J.

Mol Cell Proteomics. 2017 Oct;16(10):1789-1800. doi: 10.1074/mcp.RA117.000116. Epub 2017 Aug 16.

PMID:
28814509
10.

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.

PMID:
28613820
11.

Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor.

Tallman KA, Kim HH, Korade Z, Genaro-Mattos TC, Wages PA, Liu W, Porter NA.

Redox Biol. 2017 Aug;12:182-190. doi: 10.1016/j.redox.2017.02.013. Epub 2017 Feb 24.

12.

Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome.

Sharif NF, Korade Z, Porter NA, Harrison FE.

Genes Brain Behav. 2017 Jul;16(6):619-626. doi: 10.1111/gbb.12376. Epub 2017 Mar 15.

13.

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.

Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H.

J Biol Chem. 2017 Mar 31;292(13):5378-5391. doi: 10.1074/jbc.M116.751909. Epub 2017 Feb 15.

14.

Effect of psychotropic drug treatment on sterol metabolism.

Korade Ž, Liu W, Warren EB, Armstrong K, Porter NA, Konradi C.

Schizophr Res. 2017 Sep;187:74-81. doi: 10.1016/j.schres.2017.02.001. Epub 2017 Feb 12.

15.

Propagation rate constants for the peroxidation of sterols on the biosynthetic pathway to cholesterol.

Lamberson CR, Muchalski H, McDuffee KB, Tallman KA, Xu L, Porter NA.

Chem Phys Lipids. 2017 Oct;207(Pt B):51-58. doi: 10.1016/j.chemphyslip.2017.01.006. Epub 2017 Feb 5.

PMID:
28174017
16.

Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.

Speen AM, Kim HH, Bauer RN, Meyer M, Gowdy KM, Fessler MB, Duncan KE, Liu W, Porter NA, Jaspers I.

J Biol Chem. 2016 Nov 25;291(48):25192-25206. Epub 2016 Oct 4.

17.

Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.

Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21). doi: 10.1073/pnas.1604984113. Epub 2016 May 9.

18.

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells.

Kim HY, Korade Z, Tallman KA, Liu W, Weaver CD, Mirnics K, Porter NA.

Chem Res Toxicol. 2016 May 16;29(5):892-900. doi: 10.1021/acs.chemrestox.6b00054. Epub 2016 Apr 28.

19.

Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients.

Griffiths WJ, Abdel-Khalik J, Crick PJ, Ogundare M, Shackleton CH, Tuschl K, Kwok MK, Bigger BW, Morris AA, Honda A, Xu L, Porter NA, Björkhem I, Clayton PT, Wang Y.

J Steroid Biochem Mol Biol. 2017 May;169:77-87. doi: 10.1016/j.jsbmb.2016.03.018. Epub 2016 Mar 11.

20.

Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis.

Herron J, Reese RC, Tallman KA, Narayanaswamy R, Porter NA, Xu L.

Toxicol Sci. 2016 Jun;151(2):261-70. doi: 10.1093/toxsci/kfw041. Epub 2016 Feb 26.

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