Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Emerg Care. 2014 Feb;30(2):120-4; quiz 125-7. doi: 10.1097/PEC.0000000000000079.

Infant botulism and indications for administration of botulism immune globulin.

Author information

  • 1Resident Physician (Pifko), Pediatric Emergency Medicine Fellow (Price), Pediatric Emergency Medicine Attending Physician (Sterner), Medical University of South Carolina, Charleston, SC.

Abstract

Infant botulism is caused by the ingestion of Clostridium botulinum spores and leads to a life-threatening descending motor weakness and flaccid paralysis in infant children. This disease presents with symptoms such as constipation, weakness, and hypotonia and can lead to respiratory failure. Botulism immune globulin (BIG) was created to treat this deadly disease and functions by neutralizing all systemically circulating botulism toxins. It is indicated in children with clinically diagnosed infant botulism, before diagnostic confirmation, and has been shown to lead to a significant reduction in intensive care unit and hospital stay for these patients. This review article discusses the epidemiology, clinical presentation, history of BIG, and indications for administration of BIG.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk