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Items: 1 to 20 of 212

1.

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu CF, Brandt GS, Hoang QQ, Naumova N, Lazarevic V, Hwang ES, Dekker J, Glimcher LH, Ringe D, Petsko GA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6572-E6581. Epub 2016 Oct 10.

2.

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.

Bassil F, Fernagut PO, Bezard E, Pruvost A, Leste-Lasserre T, Hoang QQ, Ringe D, Petsko GA, Meissner WG.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9593-8. doi: 10.1073/pnas.1609291113. Epub 2016 Aug 1.

3.

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92. doi: 10.1073/pnas.1610099113. Epub 2016 Aug 1.

4.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

5.

Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.

Deshpande AR, Wagenpfeil K, Pochapsky TC, Petsko GA, Ringe D.

Biochemistry. 2016 Mar 8;55(9):1398-407. doi: 10.1021/acs.biochem.5b01319. Epub 2016 Feb 24.

6.

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.

Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. doi: 10.1073/pnas.1509742112. Epub 2015 Jun 29.

7.

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.

Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7821-6. doi: 10.1073/pnas.1509744112. Epub 2015 Jun 8.

8.

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.

Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG.

Lancet Neurol. 2015 Aug;14(8):855-866. doi: 10.1016/S1474-4422(15)00006-X. Epub 2015 Jun 3. Review.

9.

The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.

Berman DE, Ringe D, Petsko GA, Small SA.

Neurotherapeutics. 2015 Jan;12(1):12-8. doi: 10.1007/s13311-014-0321-y. Review.

10.

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.

Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR 3rd, Liddington RC, Lipton SA.

J Neurosci. 2014 Nov 5;34(45):15123-31. doi: 10.1523/JNEUROSCI.4751-13.2014.

11.

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.

12.

Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.

Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL.

Gene Ther. 2015 Jan;22(1):20-8. doi: 10.1038/gt.2014.101. Epub 2014 Nov 6.

13.

Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR.

Keedy DA, van den Bedem H, Sivak DA, Petsko GA, Ringe D, Wilson MA, Fraser JS.

Structure. 2014 Jun 10;22(6):899-910. doi: 10.1016/j.str.2014.04.016. Epub 2014 May 29.

14.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J.

PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132. eCollection 2014 May.

15.

Pharmacological chaperones stabilize retromer to limit APP processing.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.

Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20.

16.

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.

Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN.

Proteomics. 2014 May;14(10):1152-7. doi: 10.1002/pmic.201300450. Epub 2014 Apr 17.

17.

Structure of a eukaryotic thiaminase I.

Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110. Epub 2013 Dec 18.

18.

Open questions: Zombie projects, translational research, and the real secret of the inside of the cell.

Petsko GA.

BMC Biol. 2013 Sep 2;11:97. doi: 10.1186/1741-7007-11-97. No abstract available.

19.

Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC, Hoang QQ, Belitsky BR, Petsko GA, Ringe D, Liu D.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17820-5. doi: 10.1073/pnas.1315887110. Epub 2013 Oct 14.

20.

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.

Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC.

J Clin Invest. 2013 Sep;123(9):4010-22. doi: 10.1172/JCI69443. Epub 2013 Aug 15.

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