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Items: 1 to 20 of 176


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23.


Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.


Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.


Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11285-E11292. doi: 10.1073/pnas.1716990115. Epub 2017 Dec 13.


Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.


Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.


Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.


A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.


Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.

Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL.

Osteoporos Int. 2017 Jun;28(6):2011-2017. doi: 10.1007/s00198-017-3977-4. Epub 2017 Mar 10.


A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI.

Cell Metab. 2017 Mar 7;25(3):749-756. doi: 10.1016/j.cmet.2016.12.017. Epub 2017 Jan 19.


Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.

Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH.

Pediatr Transplant. 2016 Dec;20(8):1157-1163. doi: 10.1111/petr.12819. Epub 2016 Oct 20.


Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI.

Cell Metab. 2016 Jul 12;24(1):167-71. doi: 10.1016/j.cmet.2016.06.005.


Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12.


Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.


Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI.

Nature. 2016 Jun 9;534(7606):213-7. doi: 10.1038/nature18309.


Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI.

J Biol Chem. 2016 Jun 3;291(23):12161-70. doi: 10.1074/jbc.M116.720631. Epub 2016 Mar 21.


Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Perry RJ, Petersen KF, Shulman GI.

Diabetologia. 2016 May;59(5):933-7. doi: 10.1007/s00125-016-3909-4. Epub 2016 Mar 10. Review.


Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

Camporez JP, Petersen MC, Abudukadier A, Moreira GV, Jurczak MJ, Friedman G, Haqq CM, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2212-7. doi: 10.1073/pnas.1525795113. Epub 2016 Feb 8.


Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT.

FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999. Epub 2015 Dec 7.


Effect of aging on muscle mitochondrial substrate utilization in humans.

Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11330-4. doi: 10.1073/pnas.1514844112. Epub 2015 Aug 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5762.

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