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Items: 1 to 20 of 84


Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis.

Gu JJ, Rouse C, Xu X, Wang J, Onaitis MW, Pendergast AM.

JCI Insight. 2016 Dec 22;1(21):e89647. doi: 10.1172/jci.insight.89647.


Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.

J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31.


ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.

Wang J, Rouse C, Jasper JS, Pendergast AM.

Sci Signal. 2016 Feb 2;9(413):ra12. doi: 10.1126/scisignal.aad3210.


Multifunctional Abl kinases in health and disease.

Khatri A, Wang J, Pendergast AM.

J Cell Sci. 2016 Jan 1;129(1):9-16. doi: 10.1242/jcs.175521. Review.


The Emerging Role of ABL Kinases in Solid Tumors.

Wang J, Pendergast AM.

Trends Cancer. 2015 Oct 1;1(2):110-123.


Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.

Li R, Knight JF, Park M, Pendergast AM.

PLoS One. 2015 May 6;10(5):e0124960. doi: 10.1371/journal.pone.0124960. eCollection 2015.


ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

Trampont PC, Zhang L, Giles AJ, Walk SF, Gu JJ, Pendergast AM, Ravichandran KS.

Mol Cell Biol. 2015 Apr;35(8):1462-76. doi: 10.1128/MCB.01084-14. Epub 2015 Feb 17.


Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM.

Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005.


Abl family kinases regulate endothelial barrier function in vitro and in mice.

Chislock EM, Pendergast AM.

PLoS One. 2013 Dec 19;8(12):e85231. doi: 10.1371/journal.pone.0085231. eCollection 2013.


Tie2 (to) Abl: Signaling to endothelial cell survival.

Chislock EM, Pendergast AM.

Cell Cycle. 2013 Dec 15;12(24):3709-10. doi: 10.4161/cc.26877. Epub 2013 Oct 21. No abstract available.


Role of ABL family kinases in cancer: from leukaemia to solid tumours.

Greuber EK, Smith-Pearson P, Wang J, Pendergast AM.

Nat Rev Cancer. 2013 Aug;13(8):559-71. doi: 10.1038/nrc3563. Epub 2013 Jul 11. Review.


Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.

Chislock EM, Ring C, Pendergast AM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12432-7. doi: 10.1073/pnas.1304188110. Epub 2013 Jul 9.


Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

Greuber EK, Pendergast AM.

J Immunol. 2012 Dec 1;189(11):5382-92. doi: 10.4049/jimmunol.1200974. Epub 2012 Oct 24.


Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.

Gu JJ, Lavau CP, Pugacheva E, Soderblom EJ, Moseley MA, Pendergast AM.

Sci Signal. 2012 Jul 17;5(233):ra51. doi: 10.1126/scisignal.2002632.


Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways.

Li R, Pendergast AM.

Curr Biol. 2011 Sep 27;21(18):1534-42. doi: 10.1016/j.cub.2011.08.023. Epub 2011 Sep 8.


Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.

Ring C, Ginsberg MH, Haling J, Pendergast AM.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):149-54. doi: 10.1073/pnas.1012316108. Epub 2010 Dec 20.


Abl kinases are required for invadopodia formation and chemokine-induced invasion.

Smith-Pearson PS, Greuber EK, Yogalingam G, Pendergast AM.

J Biol Chem. 2010 Dec 17;285(51):40201-11. doi: 10.1074/jbc.M110.147330. Epub 2010 Oct 11.


Abl tyrosine kinases in T-cell signaling.

Gu JJ, Ryu JR, Pendergast AM.

Immunol Rev. 2009 Mar;228(1):170-83. doi: 10.1111/j.1600-065X.2008.00751.x. Review.


Regulation of cell-cell adhesion by Abi/Diaphanous complexes.

Ryu JR, Echarri A, Li R, Pendergast AM.

Mol Cell Biol. 2009 Apr;29(7):1735-48. doi: 10.1128/MCB.01483-08. Epub 2009 Jan 21.


Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.

Yogalingam G, Pendergast AM.

J Biol Chem. 2008 Dec 19;283(51):35941-53. doi: 10.1074/jbc.M804543200. Epub 2008 Oct 21.

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