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Items: 17


Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.

Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE.

Anesthesiology. 2017 Nov;127(5):824-837. doi: 10.1097/ALN.0000000000001840.


Sedative-hypnotic Binding to 11β-hydroxylase.

Pejo E, Zhou X, Husain SS, Raines DE.

Anesthesiology. 2016 Nov;125(5):943-951.


Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.

Pejo E, Liu J, Lin X, Raines DE.

Anesth Analg. 2016 Apr;122(4):1008-14. doi: 10.1213/ANE.0000000000001146.


γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.

Pejo E, Santer P, Wang L, Dershwitz P, Husain SS, Raines DE.

Anesthesiology. 2016 Mar;124(3):651-63. doi: 10.1097/ALN.0000000000000992.


Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis.

Santer P, Pejo E, Feng Y, Chao W, Raines DE.

Anesthesiology. 2015 Aug;123(2):368-76. doi: 10.1097/ALN.0000000000000721.


Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.

Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE.

Anesthesiology. 2014 Aug;121(2):290-301. doi: 10.1097/ALN.0000000000000268.


The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.

Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE.

Anesth Analg. 2014 Mar;118(3):563-7. doi: 10.1213/ANE.0000000000000069.


Azo-propofols: photochromic potentiators of GABA(A) receptors.

Stein M, Middendorp SJ, Carta V, Pejo E, Raines DE, Forman SA, Sigel E, Trauner D.

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10500-4. doi: 10.1002/anie.201205475. Epub 2012 Sep 11.


Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.

Husain SS, Pejo E, Ge R, Raines DE.

Anesthesiology. 2012 Nov;117(5):1027-36. doi: 10.1097/ALN.0b013e31826d3bef.


Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.

Ge R, Pejo E, Husain SS, Cotten JF, Raines DE.

Anesthesiology. 2012 Nov;117(5):1037-43. doi: 10.1097/ALN.0b013e31826d3de2.


Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.

Pierce DW, Pejo E, Raines DE, Forman SA.

Anesth Analg. 2012 Jul;115(1):70-2. doi: 10.1213/ANE.0b013e318254273e. Epub 2012 Apr 27.


Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.

Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE.

Anesthesiology. 2012 May;116(5):1057-65. doi: 10.1097/ALN.0b013e3182515403.


Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite.

Ge RL, Pejo E, Haburcak M, Husain SS, Forman SA, Raines DE.

Anesth Analg. 2012 Aug;115(2):305-8. doi: 10.1213/ANE.0b013e318239c6ca. Epub 2011 Nov 3.


In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.

Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE.

Anesth Analg. 2012 Aug;115(2):297-304. doi: 10.1213/ANE.0b013e3182320559. Epub 2011 Sep 29.


Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.

Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE.

Crit Care Med. 2012 Jan;40(1):187-92. doi: 10.1097/CCM.0b013e31822d7924.


Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE.

Anesthesiology. 2011 Oct;115(4):764-73. doi: 10.1097/ALN.0b013e31821950de.

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