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Aqueous extract from Pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice.

Hilbig J, Policarpi PB, de Souza Grinevicius VMA, Santos Mota NSR, Pedrosa RC, Block JM.

J Ethnopharmacol. 2017 Aug 11. pii: S0378-8741(17)31830-5. doi: 10.1016/j.jep.2017.08.012. [Epub ahead of print]


The demographic, genetic, and clinical characteristics of Brazilian subjects enrolled in the Transthyretin Amyloidosis Outcomes Survey.

Cruz MW, Foguel D, Berensztejn AC, Pedrosa RC, Mundayat R, Ong ML; THAOS Investigators.

Amyloid. 2017 Mar;24(sup1):103-104. doi: 10.1080/13506129.2017.1291423. No abstract available.


Autoantibodies with beta-adrenergic activity from chronic chagasic patients induce cardiac arrhythmias and early afterdepolarization in a drug-induced LQT2 rabbit hearts.

Jiménez MAV, Nascimento JHM, Monnerat G, Maciel L, Paiva CN, Pedrosa RC, Campos de Carvalho AC, Medei E.

Int J Cardiol. 2017 Aug 1;240:354-359. doi: 10.1016/j.ijcard.2017.02.066. Epub 2017 Mar 1.


Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats.

Kviecinski MR, David IM, Fernandes FS, Correa MD, Clarinda MM, Freitas AF, Silva JD, Gava M, Müller SD, Florentino D, Petronilho F, Moterle D, Kanis LA, Pedrosa RC.

Pharm Biol. 2017 Dec;55(1):641-648.


Low frequency of cardniac arrhythmias and lack of structural heart disease in medically-naïve acromegaly patients: a prospective study at baseline and after 1 year of somatostatin analogs treatment.

Warszawski L, Kasuki L, Sá R, Dos Santos Silva CM, Volschan I, Gottlieb I, Pedrosa RC, Gadelha MR.

Pituitary. 2016 Dec;19(6):582-589.


Albendazole as a promising molecule for tumor control.

Castro LS, Kviecinski MR, Ourique F, Parisotto EB, Grinevicius VM, Correia JF, Wilhelm Filho D, Pedrosa RC.

Redox Biol. 2016 Dec;10:90-99. doi: 10.1016/j.redox.2016.09.013. Epub 2016 Sep 22.


In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate.

Ourique F, Kviecinski MR, Zirbel G, Castro LSEPW, Gomes Castro AJ, Mena Barreto Silva FR, Valderrama JA, Rios D, Benites J, Calderon PB, Pedrosa RC.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):640-646. doi: 10.1016/j.bbrc.2016.06.113. Epub 2016 Jun 24.


Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells.

de Souza Grinevicius VM, Kviecinski MR, Santos Mota NS, Ourique F, Porfirio Will Castro LS, Andreguetti RR, Gomes Correia JF, Filho DW, Pich CT, Pedrosa RC.

J Ethnopharmacol. 2016 Aug 2;189:139-47. doi: 10.1016/j.jep.2016.05.020. Epub 2016 May 10.


Low Frequency of Cardiomyopathy Using Cardiac Magnetic Resonance Imaging in an Acromegaly Contemporary Cohort.

dos Santos Silva CM, Gottlieb I, Volschan I, Kasuki L, Warszawski L, Balarini Lima GA, Xavier SS, Pedrosa RC, Neto LV, Gadelha MR.

J Clin Endocrinol Metab. 2015 Dec;100(12):4447-55. doi: 10.1210/jc.2015-2675. Epub 2015 Oct 2.


Frequency of Cardiovascular Involvement in Familial Amyloidotic Polyneuropathy in Brazilian Patients.

Queiroz MC, Pedrosa RC, Berensztejn AC, Pereira Bde B, Nascimento EM, Duarte MM, Pereira-Junior PP, Cruz MW.

Arq Bras Cardiol. 2015 Nov;105(5):503-9. doi: 10.5935/abc.20150112. Epub 2015 Sep 8. English, Portuguese.


Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome.

Parisotto EB, Giaretta AG, Zamoner A, Moreira EA, Fröde TS, Pedrosa RC, Filho DW.

Res Dev Disabil. 2015 Oct-Nov;45-46:14-20. doi: 10.1016/j.ridd.2015.07.010. Epub 2015 Jul 23.


Assessment of Autonomic Function by Phase Rectification of RRInterval Histogram Analysis in Chagas Disease.

Nasario-Junior O, Benchimol-Barbosa PR, Pedrosa RC, Nadal J.

Arq Bras Cardiol. 2015 Jun;104(6):450-5. doi: 10.5935/abc.20150032. Epub 2015 Apr 14. English, Portuguese.


Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging.

Zottis AD, Beltrame JM, Lara LR, Costa TG, Feldhaus MJ, Pedrosa RC, Ourique F, de Campos CE, Isoppo Ede A, da Silva Miranda F, Szpoganicz B.

Chem Commun (Camb). 2015 Jun 30;51(56):11194-7. doi: 10.1039/c5cc02536b.


Assessment of Autonomic Function by Phase Rectification of RRInterval Histogram Analysis in Chagas Disease.

Nasari Junior O, Benchimol-Barbosa PR, Pedrosa RC, Nadal J.

Arq Bras Cardiol. 2015 Apr 14. pii: S0066-782X2015005050032. [Epub ahead of print] Portuguese, English.


DNA damage and inhibition of akt pathway in mcf-7 cells and ehrlich tumor in mice treated with 1,4-naphthoquinones in combination with ascorbate.

Ourique F, Kviecinski MR, Felipe KB, Correia JF, Farias MS, Castro LS, Grinevicius VM, Valderrama J, Rios D, Benites J, Calderon PB, Pedrosa RC.

Oxid Med Cell Longev. 2015;2015:495305. doi: 10.1155/2015/495305. Epub 2015 Feb 22.


Impact of the Use of Benznidazole Followed by Antioxidant Supplementation in the Prevalence of Ventricular Arrhythmias in Patients With Chronic Chagas Disease: Pilot Study.

Barbosa JL, Thiers CA, de Bragança Pereira B, do Nascimento EM, Ribeiro Frazon CM, Budni P, Wilhelm Filho D, Pedrosa RC.

Am J Ther. 2016 Nov/Dec;23(6):e1474-e1483.


Inhibition of tumor proliferation associated with cell cycle arrest caused by extract and fraction from Casearia sylvestris (Salicaceae).

Felipe KB, Kviecinski MR, da Silva FO, Bücker NF, Farias MS, Castro LS, de Souza Grinevicius VM, Motta NS, Correia JF, Rossi MH, Pedrosa RC.

J Ethnopharmacol. 2014 Sep 29;155(3):1492-9. doi: 10.1016/j.jep.2014.07.040. Epub 2014 Jul 28.


Relationship between fibrosis and ventricular arrhythmias in Chagas heart disease without ventricular dysfunction.

Tassi EM, Continentino MA, Nascimento EM, Pereira Bde B, Pedrosa RC.

Arq Bras Cardiol. 2014 May;102(5):456-64. Epub 2014 May 9. English, Portuguese.


Substituted 3‑acyl‑2‑phenylamino‑1,4‑naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death.

Farias MS, Pich CT, Kviecinski MR, Bucker NC, Felipe KB, Da Silva FO, Günther TM, Correia JF, Ríos D, Benites J, Valderrama JA, Calderon PB, Pedrosa RC.

Mol Med Rep. 2014 Jul;10(1):405-10. doi: 10.3892/mmr.2014.2160. Epub 2014 Apr 16.


Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome.

Parisotto EB, Garlet TR, Cavalli VL, Zamoner A, da Rosa JS, Bastos J, Micke GA, Fröde TS, Pedrosa RC, Wilhelm Filho D.

Res Dev Disabil. 2014 Jun;35(6):1228-36. doi: 10.1016/j.ridd.2014.03.013. Epub 2014 Mar 28.


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