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Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia.

Heitmeier MR, Payne MA, Weinheimer C, Kovacs A, Hresko RC, Jay PY, Hruz PW.

Sci Rep. 2018 Apr 24;8(1):6475. doi: 10.1038/s41598-018-24867-1.


Evaluating the Efficacy of GLUT Inhibitors Using a Seahorse Extracellular Flux Analyzer.

Wei C, Heitmeier M, Hruz PW, Shanmugam M.

Methods Mol Biol. 2018;1713:69-75. doi: 10.1007/978-1-4939-7507-5_6.


Development of GLUT4-selective antagonists for multiple myeloma therapy.

Wei C, Bajpai R, Sharma H, Heitmeier M, Jain AD, Matulis SM, Nooka AK, Mishra RK, Hruz PW, Schiltz GE, Shanmugam M.

Eur J Med Chem. 2017 Oct 20;139:573-586. doi: 10.1016/j.ejmech.2017.08.029. Epub 2017 Aug 14.


MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.

Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO.

Sci Rep. 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017-07159-y.


SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.

Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ.

Sci Rep. 2016 Dec 6;6:38586. doi: 10.1038/srep38586.


A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec.


Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids.

Hresko RC, Kraft TE, Quigley A, Carpenter EP, Hruz PW.

J Biol Chem. 2016 Aug 12;291(33):17271-82. doi: 10.1074/jbc.M116.730168. Epub 2016 Jun 14.


Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.

DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH.

Sci Signal. 2016 Feb 23;9(416):ra21. doi: 10.1126/scisignal.aac5472.



Hruz PW.

Clin Chem. 2015 Dec;61(12):1444. doi: 10.1373/clinchem.2015.243964. No abstract available.


Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.

Kraft TE, Hresko RC, Hruz PW.

Protein Sci. 2015 Dec;24(12):2008-19. doi: 10.1002/pro.2812. Epub 2015 Oct 14.


The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.

Kraft TE, Armstrong C, Heitmeier MR, Odom AR, Hruz PW.

Antimicrob Agents Chemother. 2015 Oct;59(10):6203-9. doi: 10.1128/AAC.00899-15. Epub 2015 Jul 27.


In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.

Mishra RK, Wei C, Hresko RC, Bajpai R, Heitmeier M, Matulis SM, Nooka AK, Rosen ST, Hruz PW, Schiltz GE, Shanmugam M.

J Biol Chem. 2015 Jun 5;290(23):14441-53. doi: 10.1074/jbc.M114.628826. Epub 2015 Apr 6.


HIV and endocrine disorders.

Hruz PW.

Endocrinol Metab Clin North Am. 2014 Sep;43(3):xvii-xviii. doi: 10.1016/j.ecl.2014.07.001. No abstract available.


Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.

Hresko RC, Kraft TE, Tzekov A, Wildman SA, Hruz PW.

J Biol Chem. 2014 Jun 6;289(23):16100-13. doi: 10.1074/jbc.M113.528430. Epub 2014 Apr 4.


Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy.

Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW.

Cardiovasc Endocrinol. 2012 Dec;1(4):74-82.


GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle.

Aerni-Flessner L, Abi-Jaoude M, Koenig A, Payne M, Hruz PW.

Cardiovasc Diabetol. 2012 Jun 8;11:63. doi: 10.1186/1475-2840-11-63.


Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.

Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG.

Diabetes. 2011 Oct;60(10):2515-22. doi: 10.2337/db11-0538. Epub 2011 Aug 3.


Molecular mechanisms for insulin resistance in treated HIV-infection.

Hruz PW.

Best Pract Res Clin Endocrinol Metab. 2011 Jun;25(3):459-68. doi: 10.1016/j.beem.2010.10.017. Review.


Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.

Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW.

PLoS One. 2011 Feb 17;6(2):e17178. doi: 10.1371/journal.pone.0017178.

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