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Items: 1 to 20 of 39

1.

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ.

Nat Commun. 2018 Aug 24;9(1):3411. doi: 10.1038/s41467-018-05646-y.

2.

Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation.

Jakobsson ME, Małecki J, Falnes PØ.

RNA Biol. 2018 Mar 4;15(3):314-319. doi: 10.1080/15476286.2018.1440875. Epub 2018 Mar 9.

PMID:
29447067
3.

Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Małecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes PØ, Eijkelkamp N.

PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.

4.

Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.

Małecki J, Jakobsson ME, Ho AYY, Moen A, Rustan AC, Falnes PØ.

J Biol Chem. 2017 Oct 27;292(43):17950-17962. doi: 10.1074/jbc.M117.808451. Epub 2017 Sep 8.

PMID:
28887308
5.

Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

Jakobsson ME, Malecki J, Nilges BS, Moen A, Leidel SA, Falnes PØ.

Nucleic Acids Res. 2017 Aug 21;45(14):8239-8254. doi: 10.1093/nar/gkx432.

6.

A System for Enzymatic Lysine Methylation in a Desired Sequence Context.

Aileni VK, Davydova E, Moen A, Falnes PØ.

ACS Omega. 2017 Feb 28;2(2):462-469. doi: 10.1021/acsomega.6b00486. Epub 2017 Feb 10.

7.

The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).

Malecki J, Aileni VK, Ho AYY, Schwarz J, Moen A, Sørensen V, Nilges BS, Jakobsson ME, Leidel SA, Falnes PØ.

Nucleic Acids Res. 2017 May 5;45(8):4370-4389. doi: 10.1093/nar/gkx002.

8.

Protein lysine methylation by seven-β-strand methyltransferases.

Falnes PØ, Jakobsson ME, Davydova E, Ho A, Małecki J.

Biochem J. 2016 Jul 15;473(14):1995-2009. doi: 10.1042/BCJ20160117. Review.

PMID:
27407169
9.

Correspondence: On the enzymology and significance of HSPA1 lysine methylation.

Jakobsson ME, Moen A, Falnes PØ.

Nat Commun. 2016 Jun 20;7:11464. doi: 10.1038/ncomms11464. No abstract available.

10.
11.

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.

Fusser M, Kernstock S, Aileni VK, Egge-Jacobsen W, Falnes PØ, Klungland A.

PLoS One. 2015 Nov 6;10(11):e0141472. doi: 10.1371/journal.pone.0141472. eCollection 2015.

12.

Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.

Jakobsson ME, Moen A, Davidson B, Falnes PØ.

PLoS One. 2015 Oct 8;10(10):e0140168. doi: 10.1371/journal.pone.0140168. eCollection 2015.

13.

Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase.

Jakobsson ME, Davydova E, Małecki J, Moen A, Falnes PØ.

PLoS One. 2015 Jun 26;10(6):e0131426. doi: 10.1371/journal.pone.0131426. eCollection 2015.

14.

Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.

Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B.

DNA Repair (Amst). 2015 Jun;30:1-10. doi: 10.1016/j.dnarep.2015.02.021. Epub 2015 Mar 5.

15.

Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.

Małecki J, Ho AY, Moen A, Dahl HA, Falnes PØ.

J Biol Chem. 2015 Jan 2;290(1):423-34. doi: 10.1074/jbc.M114.614115. Epub 2014 Nov 21.

16.

Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2).

Davydova E, Ho AY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PØ.

J Biol Chem. 2014 Oct 31;289(44):30499-510. doi: 10.1074/jbc.M114.601658. Epub 2014 Sep 17.

17.

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ.

PLoS One. 2014 Jun 10;9(6):e98729. doi: 10.1371/journal.pone.0098729. eCollection 2014.

18.

Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.

Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PØ.

J Biol Chem. 2013 Sep 27;288(39):27752-63. doi: 10.1074/jbc.M113.483248. Epub 2013 Aug 6.

19.

Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.

Lin FJ, Shen L, Jang CW, Falnes PØ, Zhang Y.

PLoS Genet. 2013 May;9(5):e1003516. doi: 10.1371/journal.pgen.1003516. Epub 2013 May 23.

20.

Human ALKBH4 interacts with proteins associated with transcription.

Bjørnstad LG, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA, Falnes PØ.

PLoS One. 2012;7(11):e49045. doi: 10.1371/journal.pone.0049045. Epub 2012 Nov 8.

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