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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.

Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR; CANVAS Program Collaborative Group.

N Engl J Med. 2017 Aug 17;377(7):644-657. doi: 10.1056/NEJMoa1611925. Epub 2017 Jun 12.


Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients.

Liu Q, Hesson LB, Nunez AC, Packham D, Hawkins NJ, Ward RL, Sloane MA.

Cancer Genet. 2016 Nov;209(11):497-500. doi: 10.1016/j.cancergen.2016.10.001. Epub 2016 Oct 11.


Allogeneic Mesenchymal Precursor Cells (MPC) in Diabetic Nephropathy: A Randomized, Placebo-controlled, Dose Escalation Study.

Packham DK, Fraser IR, Kerr PG, Segal KR.

EBioMedicine. 2016 Oct;12:263-269. doi: 10.1016/j.ebiom.2016.09.011. Epub 2016 Sep 17.


Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.

Hesson LB, Ng B, Zarzour P, Srivastava S, Kwok CT, Packham D, Nunez AC, Beck D, Ryan R, Dower A, Ford CE, Pimanda JE, Sloane MA, Hawkins NJ, Bourke MJ, Wong JW, Ward RL.

Mol Cancer Res. 2016 Dec;14(12):1217-1228. Epub 2016 Sep 26.


Successful treatment of cutaneous protothecosis with liposomal amphotericin and oral itraconazole.

McMullan B, Pollett S, Biswas C, Packham D.

Med Mycol Case Rep. 2016 Aug 3;12:21-3. doi: 10.1016/j.mmcr.2016.08.001. eCollection 2016 Jun.


Pharmacodynamics and pharmacokinetics of sodium zirconium cyclosilicate [ZS-9] in the treatment of hyperkalemia.

Packham DK, Kosiborod M.

Expert Opin Drug Metab Toxicol. 2016 May;12(5):567-73. doi: 10.1517/17425255.2016.1164691. Epub 2016 Apr 5. Review.


Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.

Pokorney SD, Piccini JP, Stevens SR, Patel MR, Pieper KS, Halperin JL, Breithardt G, Singer DE, Hankey GJ, Hacke W, Becker RC, Berkowitz SD, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Steering Committee & Investigators; ROCKET AF Steering Committee Investigators.

J Am Heart Assoc. 2016 Mar 8;5(3):e002197. doi: 10.1161/JAHA.115.002197.


Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.

Thoms JA, Knezevic K, Liu JJ, Glaros EN, Thai T, Qiao Q, Campbell H, Packham D, Huang Y, Papathanasiou P, Tunningley R, Whittle B, Yeung AW, Chandrakanthan V, Hesson L, Chen V, Wong JW, Purton LE, Ward RL, Thomas SR, Pimanda JE.

Mol Cell Biol. 2016 Mar 31;36(8):1222-36. doi: 10.1128/MCB.01035-15. Print 2016 Apr.


A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial.

Brigandi RA, Johnson B, Oei C, Westerman M, Olbina G, de Zoysa J, Roger SD, Sahay M, Cross N, McMahon L, Guptha V, Smolyarchuk EA, Singh N, Russ SF, Kumar S; PHI112844 Investigators.

Am J Kidney Dis. 2016 Jun;67(6):861-71. doi: 10.1053/j.ajkd.2015.11.021. Epub 2016 Jan 27.


Individual long-term albuminuria exposure during angiotensin receptor blocker therapy is the optimal predictor for renal outcome.

Felix Kröpelin T, de Zeeuw D, Holtkamp FA, Packham DK, L Heerspink HJ.

Nephrol Dial Transplant. 2016 Sep;31(9):1471-7. doi: 10.1093/ndt/gfv429. Epub 2016 Jan 19.


A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome.

Liu Q, Hesson LB, Nunez AC, Packham D, Williams R, Ward RL, Sloane MA.

Carcinogenesis. 2016 Jan;37(1):10-17. doi: 10.1093/carcin/bgv154. Epub 2015 Oct 24.


Efficacy and safety of canagliflozin when used in conjunction with incretin-mimetic therapy in patients with type 2 diabetes.

Fulcher G, Matthews DR, Perkovic V, de Zeeuw D, Mahaffey KW, Mathieu C, Woo V, Wysham C, Capuano G, Desai M, Shaw W, Vercruysse F, Meininger G, Neal B; CANVAS trial collaborative group.

Diabetes Obes Metab. 2016 Jan;18(1):82-91. doi: 10.1111/dom.12589. Epub 2015 Dec 8.


Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.

Bakris GL, Agarwal R, Chan JC, Cooper ME, Gansevoort RT, Haller H, Remuzzi G, Rossing P, Schmieder RE, Nowack C, Kolkhof P, Joseph A, Pieper A, Kimmeskamp-Kirschbaum N, Ruilope LM; Mineralocorticoid Receptor Antagonist Tolerability Study–Diabetic Nephropathy (ARTS-DN) Study Group.

JAMA. 2015 Sep 1;314(9):884-94. doi: 10.1001/jama.2015.10081.


Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.

Sloane MA, Nunez AC, Packham D, Kwok CT, Suthers G, Hesson LB, Ward RL.

JAMA Oncol. 2015 Oct;1(7):953-7. doi: 10.1001/jamaoncol.2015.1484.


Potential New Agents for the Management of Hyperkalemia.

Packham DK, Kosiborod M.

Am J Cardiovasc Drugs. 2016 Feb;16(1):19-31. doi: 10.1007/s40256-015-0130-7. Review.


Modern technology and infectious diseases activity data: how can we use this for service planning?

Keighley C, Hamor P, Chen S, Watts MR, Douglas MW, Kok J, O'Sullivan M, Mitchell DH, Packham D, Sorrell TC, Iredell JR.

Intern Med J. 2015 Jun;45(6):688. doi: 10.1111/imj.12772. No abstract available.


New agents for hyperkalemia.

Packham DK, Rasmussen HS, Singh B.

N Engl J Med. 2015 Apr 16;372(16):1571-2. No abstract available.


Sodium zirconium cyclosilicate for urgent therapy of severe hyperkalemia.

Kosiborod M, Peacock WF, Packham DK.

N Engl J Med. 2015 Apr 16;372(16):1577-8. doi: 10.1056/NEJMc1500353. No abstract available.


Delusional infestation: an Australian multicentre study of 23 consecutive cases.

Tran MM, Iredell JR, Packham DR, O'Sullivan MV, Hudson BJ.

Intern Med J. 2015 Apr;45(4):454-6. doi: 10.1111/imj.12719.


Lynch syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.

Hesson LB, Packham D, Kwok CT, Nunez AC, Ng B, Schmidt C, Fields M, Wong JW, Sloane MA, Ward RL.

Hum Mutat. 2015 Jun;36(6):622-30. doi: 10.1002/humu.22785. Epub 2015 Apr 17.

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