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J Mol Diagn. 2006 Sep;8(4):521-5; quiz 528.

Application of multicolor banding for identification of complex chromosome 18 rearrangements.

Author information

1
Department of Genetics, Magee-Womens Hospital Pittsburgh, PA 15213, USA. jhu@mail.magee.edu

Abstract

Multicolor chromosome banding (mBAND) is a recently developed technique that allows the delineation of chromosomal regions with a resolution of a few megabase pairs. The resolution of mBAND is slightly below that of conventional chromosome banding; however, the color bands have a great value in identifying chromosomal abnormalities, particularly complex chromosome rearrangements, and intrachromosome exchanges (ie, inversions, deletions, duplications, and insertions). These abnormalities cannot be defined easily by conventional cytogenetic analysis or chromosome paint. In this report, we present the application of the mBAND analysis for identification of complex intrachromosome rearrangements of chromosome 18 in a child with dysmorphic features.

PMID:
16931594
PMCID:
PMC1867622
DOI:
10.2353/jmoldx.2006.060001
[Indexed for MEDLINE]
Free PMC Article

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