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Chem Rec. 2003;3(3):172-80.

Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.

Author information

1
Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan 11217. msshia@ughtpe.gov.tw

Abstract

Ganoderma lucidum, a fungus used in traditional Chinese medicine, produces polysaccharides and oxygenated triterpenoids with a very broad spectrum of biological activities and pharmacological functions. Among the Ganoderma triterpenoids, many pairs of C-3 alpha/beta stereoisomers and C-3/C-15 positional isomers have been identified. Biosynthetic study has indicated that the C-3alpha series of oxygenated triterpenoids is derived from the C-3beta series via an oxidation-reduction pathway. The interaction of Ganoderma triterpenoids with human platelets in the induction of aggregation and inhibition of agonist-induced aggregation and signal transduction has been elucidated. Reduction of cellular mevalonate content to a stage in which cholesterol synthesis is strongly inhibited and cell growth is marginally arrested sensitizes hepatoma cells to the oxygenated triterpenoids. A combination treatment of lovastatin and Ganoderma triterpenoids in animal studies has exhibited a potential anticancer effect.

PMID:
12900937
DOI:
10.1002/tcr.10058
[Indexed for MEDLINE]

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