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Clin Investig (Lond). 2012 Oct 1;2(10):975-984.

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.

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1
Departments of Neurology and of Pathology and Immunology, and the Programs in Physical Therapy and Occupational Therapy, Washington University, St. Louis, MO (JCM). Other authors' affiliations are as follows: the Departments of Neurology (RB, AF, DH, VB, AO, KM, NS), Biostatistics (CX), Psychiatry (AG), Radiology (TB, DM), and Pathology and Immunology (NC), Washington University School of Medicine, St. Louis; University College London Institute of Neurology, London (MR); the Department of Neurosciences, University of California, San Diego, La Jolla (PA); the Department of Pathology and Laboratory Medicine (BG) and the Center for Bioethics (KQ), Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry (WK) and Neurology (WK, EM), University of Pittsburgh School of Medicine, Pittsburgh; the Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA (RM), the Mental Health Research Institute, University of Melbourne, Melbourne, VIC (CM), and Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Sydney (PS) - all in Australia; the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York (RM); the Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (JR); the Center for Alzheimer Research and Treatment and the Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School (RS) - all in Boston; the Department of Neurology and the Memory and Aging Program, Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI (SS); and the Departments of Medicine, Radiology, and Psychiatry, University of California San Francisco (MW).

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.

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