Send to

Choose Destination
See comment in PubMed Commons below
Front Neuroinform. 2012 Mar 14;6:3. doi: 10.3389/fninf.2012.00003. eCollection 2012.

Models of the aging brain structure and individual decline.

Author information

Structural Brain Mapping Group, Department of Psychiatry, Jena University Hospital Jena, Germany.


The aging brain's structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.


aging; brain morphometry; inter-individual differences; longitudinal analysis; modeling; multivariate analysis

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center