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F1000 Med Rep. 2010 Feb 11;2. pii: 9. doi: 10.3410/M2-9.

Recent advances in management of bladder overactivity.

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Division of Urology, University of Pennsylvania, School of Medicine 3400 Spruce Street, 9 Penn Tower, Philadelphia, PA 19104 USA.


Pharmacologic therapies, primarily antimuscarinic agents, have been the mainstay of treatment for overactive bladder. These drugs produce variable efficacy, a moderate rate of side effects, and rare occurrences of cure. The search for newer and better formulations and derivatives of this class of medication as well as novel therapies is ongoing and primarily fueled by the high prevalence of overactive bladder and the tremendous number of health care dollars spent on current therapy. Surgical options for overactive bladder have evolved slowly and are currently reserved for medical treatment failures and drug intolerance. This article will highlight the new drugs and therapies brought into clinical use for the treatment of overactive bladder over the last few years as well as a promising new agent in the advanced stages of development.


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