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Nat Struct Mol Biol. 2009 May;16(5):561-3. doi: 10.1038/nsmb.1587. Epub 2009 Apr 12.

The WAVE regulatory complex is inhibited.

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1
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA.

Abstract

The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

PMID:
19363480
PMCID:
PMC2716658
DOI:
10.1038/nsmb.1587
[Indexed for MEDLINE]
Free PMC Article
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