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Breast Cancer Res. 2007;9(6):216. doi: 10.1186/bcr1796.

Breast tumour angiogenesis.

Author information

1
Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, 3002, Australia. stephen.fox@petermac.org

Abstract

The central importance of tumour neovascularization has been emphasized by clinical trials using antiangiogenic therapy in breast cancer. This review gives a background to breast tumour neovascularization in in situ and invasive breast cancer, outlines the mechanisms by which this is achieved and discusses the influence of the microenvironment, focusing on hypoxia. The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized.

PMID:
18190723
PMCID:
PMC2246178
DOI:
10.1186/bcr1796
[Indexed for MEDLINE]
Free PMC Article

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