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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 1
2012 3
2013 1
2014 3
2015 4
2016 3
2017 9
2018 5
2019 5
2020 6
2021 10
2022 14
2023 13
2024 1

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68 results

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Page 1
PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors.
Quintanilha JCF, Racioppi A, Wang J, Etheridge AS, Denning S, Peña CE, Skol AD, Crona DJ, Lin D, Innocenti F. Quintanilha JCF, et al. Pharmacogenomics J. 2022 Feb;22(1):82-88. doi: 10.1038/s41397-021-00261-5. Epub 2021 Nov 13. Pharmacogenomics J. 2022. PMID: 34775477 Free PMC article.
The most statistically significant SNPs associated with grade 2 hypertension were tested for association with grade 2 hypertension in the replication set of a GWAS of 1039 bevacizumab-treated patients from four clinical trials (CALGB/Alliance). In the discovery set, rs444904 (G & …
The most statistically significant SNPs associated with grade 2 hypertension were tested for association with grade 2 hypertension in the re …
Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
Huang Z, Peng Y, Wei Y, Tan Y. Huang Z, et al. J Muscle Res Cell Motil. 2023 Mar;44(1):11-23. doi: 10.1007/s10974-022-09639-9. Epub 2022 Dec 13. J Muscle Res Cell Motil. 2023. PMID: 36512272
Here, we provide evidence that NMD plays an important role in myoblast proliferation and apoptosis. In addition, we found that PIK3R5 is an NMD substrate gene which can inhibit AKT activity and C2C12 cell proliferation. Therefore, NMD can target PIK3R5 to enhance AK …
Here, we provide evidence that NMD plays an important role in myoblast proliferation and apoptosis. In addition, we found that PIK3R5 …
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
Han X, Guo B, Zhao S, Li Y, Zhu J, He Y, Wang J, Yao Q, Shao S, Zheng L, Shi Z, Han T, Hong W, Zhang K. Han X, et al. Cell Mol Biol Lett. 2023 Oct 7;28(1):77. doi: 10.1186/s11658-023-00492-3. Cell Mol Biol Lett. 2023. PMID: 37805473 Free PMC article.
Mechanistically, our data illustrated that lnc-Helf interacts with RNA binding protein PTBP1 to promote its interaction with PIK3R5 mRNA, resulting in increased stability and activating the AKT pathway, thus promoting HSCs and HMs activation and proliferation, which augmen …
Mechanistically, our data illustrated that lnc-Helf interacts with RNA binding protein PTBP1 to promote its interaction with PIK3R5 m …
Identification of PIK3R5 as a hub in septic myocardial injury and the cardioprotective effects of Psoralidin.
Wang X, Liang Z, Liu Q, Ye X, Wu X, Deng C, Zhao L, Lu C, Qiu Z, Yao Y, Yang Y, Xu X. Wang X, et al. Phytomedicine. 2024 Jan;122:155146. doi: 10.1016/j.phymed.2023.155146. Epub 2023 Oct 17. Phytomedicine. 2024. PMID: 37918280
Furthermore, the identification of phosphoinositide 3- kinase regulatory subunit 5 (PIK3R5) as a crucial hub gene was accomplished via protein-protein interaction network and molecular docking approach. ...
Furthermore, the identification of phosphoinositide 3- kinase regulatory subunit 5 (PIK3R5) as a crucial hub gene was accomplished vi …
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis.
Qin W, Jiang M, Lu S, Hu Y, Gan F, Fang W, Chen D, Bo Z. Qin W, et al. Environ Res. 2023 Dec 1;238(Pt 1):117116. doi: 10.1016/j.envres.2023.117116. Epub 2023 Sep 12. Environ Res. 2023. PMID: 37709244

The RT-qPCR results showed that PIK3R5 and PI3K expression levels in the SANFH group were lower than those in the control group (P < 0.05), and the WB experiment results were consistent with the RT-qPCR results. ...CONCLUSION: During the occurrence and development of SA

…
The RT-qPCR results showed that PIK3R5 and PI3K expression levels in the SANFH group were lower than those in the control group (P &l …
Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability.
Lv G, Wang B, Li L, Li Y, Li X, He H, Kuang L. Lv G, et al. Bone Joint Res. 2022 Sep;11(9):652-668. doi: 10.1302/2046-3758.119.BJR-2021-0443.R2. Bone Joint Res. 2022. PMID: 36066338 Free PMC article.

FTO bound to PIK3R5 (p < 0.001) to inhibit the stability of PIK3R5 messenger RNA (mRNA) (p < 0.001) and disrupt the PI3K/AKT/mTOR pathway (p < 0.001). CONCLUSION: Exosomal OANCT from DC could bind to FTO protein, thereby maintaining the mRNA stability of

…

FTO bound to PIK3R5 (p < 0.001) to inhibit the stability of PIK3R5 messenger RNA (mRNA) (p < 0.001) and disrupt the PI3K

…
miR-210-5p promotes epithelial-mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells.
Liu W, Jiang D, Gong F, Huang Y, Luo Y, Rong Y, Wang J, Ge X, Ji C, Fan J, Cai W. Liu W, et al. Cell Death Dis. 2020 Feb 5;11(2):93. doi: 10.1038/s41419-020-2270-1. Cell Death Dis. 2020. PMID: 32024814 Free PMC article.
Luciferase reporter assay, RNA-ChIP, and western blot analysis confirmed that PIK3R5, an essential regulator in the AKT/mTOR signaling pathway, is a target downstream gene of miR-210-5p. Overexpression or knockdown of PIK3R5 reversed the functional role of overexpre …
Luciferase reporter assay, RNA-ChIP, and western blot analysis confirmed that PIK3R5, an essential regulator in the AKT/mTOR signalin …
HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression.
Liu Y, Jing XB, Wang ZC, Han QK. Liu Y, et al. Hum Genomics. 2021 Jun 29;15(1):38. doi: 10.1186/s40246-021-00340-5. Hum Genomics. 2021. PMID: 34187569 Free PMC article.
LncBase and TargetScan online tools were utilized to predict potential targets, and dual-luciferase reporter assay was performed to verify the association between miR-1291 and HCP5 or PIK3R5. Cell Counting Kit 8 and flow cytometry tests were implemented to evaluate the eff …
LncBase and TargetScan online tools were utilized to predict potential targets, and dual-luciferase reporter assay was performed to verify t …
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, Zhang CL, Wang Y, Xu GB, Zou SH, Wei MC, Zhang J, Zhang JJ, Liao SG. Guo XL, et al. Phytomedicine. 2023 Jul 25;116:154868. doi: 10.1016/j.phymed.2023.154868. Epub 2023 May 13. Phytomedicine. 2023. PMID: 37209608 Free article.
Finally, gene annotation results revealed that downregulation of S100A9 in the IL-17 pathway, of CCR5 and PIK3R5 in the chemokine signaling pathway, and of TLR2, ITGA4, and PIK3R5 in the PI3K-AKT signaling pathway were involved in the protective effect of alpha-vini …
Finally, gene annotation results revealed that downregulation of S100A9 in the IL-17 pathway, of CCR5 and PIK3R5 in the chemokine sig …
68 results