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Items: 1 to 20 of 21

1.

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.

Jones AM, Westwood IM, Osborne JD, Matthews TP, Cheeseman MD, Rowlands MG, Jeganathan F, Burke R, Lee D, Kadi N, Liu M, Richards M, McAndrew C, Yahya N, Dobson SE, Jones K, Workman P, Collins I, van Montfort RL.

Sci Rep. 2016 Oct 6;6:34701. doi: 10.1038/srep34701.

2.

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).

Osborne JD, Matthews TP, McHardy T, Proisy N, Cheung KM, Lainchbury M, Brown N, Walton MI, Eve PD, Boxall KJ, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Jamin Y, Robinson SP, Westwood IM, van Montfort RL, Leonard PM, Lamers MB, Reader JC, Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I.

J Med Chem. 2016 Jun 9;59(11):5221-37. doi: 10.1021/acs.jmedchem.5b01938. Epub 2016 May 23.

3.

Efficient identification of nationally mandated reportable cancer cases using natural language processing and machine learning.

Osborne JD, Wyatt M, Westfall AO, Willig J, Bethard S, Gordon G.

J Am Med Inform Assoc. 2016 Nov;23(6):1077-1084. doi: 10.1093/jamia/ocw006. Epub 2016 Mar 28.

4.

Rotator cuff rehabilitation: current theories and practice.

Osborne JD, Gowda AL, Wiater B, Wiater JM.

Phys Sportsmed. 2016;44(1):85-92. doi: 10.1080/00913847.2016.1108883. Epub 2015 Nov 7. Review.

PMID:
26548634
5.

Comparative genome analysis of Mycoplasma pneumoniae.

Xiao L, Ptacek T, Osborne JD, Crabb DM, Simmons WL, Lefkowitz EJ, Waites KB, Atkinson TP, Dybvig K.

BMC Genomics. 2015 Aug 16;16:610. doi: 10.1186/s12864-015-1801-0.

6.

Roller compaction: Effect of morphology and amorphous content of lactose powder on product quality.

Omar CS, Dhenge RM, Osborne JD, Althaus TO, Palzer S, Hounslow MJ, Salman AD.

Int J Pharm. 2015 Dec 30;496(1):63-74. doi: 10.1016/j.ijpharm.2015.06.032. Epub 2015 Jun 25.

PMID:
26117279
7.

Roller compactor: The effect of mechanical properties of primary particles.

Al-Asady RB, Osborne JD, Hounslow MJ, Salman AD.

Int J Pharm. 2015 Dec 30;496(1):124-36. doi: 10.1016/j.ijpharm.2015.05.061. Epub 2015 May 27.

PMID:
26024822
8.

Reduction of hydrogen peroxide accumulation and toxicity by a catalase from Mycoplasma iowae.

Pritchard RE, Prassinos AJ, Osborne JD, Raviv Z, Balish MF.

PLoS One. 2014 Aug 15;9(8):e105188. doi: 10.1371/journal.pone.0105188. eCollection 2014.

9.

Draft Genome Sequence of Hymenobacter sp. Strain IS2118, Isolated from a Freshwater Lake in Schirmacher Oasis, Antarctica, Reveals Diverse Genes for Adaptation to Cold Ecosystems.

Koo H, Ptacek T, Crowley M, Swain AK, Osborne JD, Bej AK, Andersen DT.

Genome Announc. 2014 Aug 7;2(4). pii: e00739-14. doi: 10.1128/genomeA.00739-14.

10.

Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms.

Simmons WL, Daubenspeck JM, Osborne JD, Balish MF, Waites KB, Dybvig K.

Microbiology. 2013 Apr;159(Pt 4):737-47. doi: 10.1099/mic.0.064782-0. Epub 2013 Feb 14.

11.

Might wipe clean covers for mobile phones reduce risk of spread of pathogens?

Osborne JD, Phull JS, Matone LI.

BMJ. 2012 Feb 7;344:e871. doi: 10.1136/bmj.e871. No abstract available.

PMID:
22315287
12.

Annotating the human genome with Disease Ontology.

Osborne JD, Flatow J, Holko M, Lin SM, Kibbe WA, Zhu LJ, Danila MI, Feng G, Chisholm RL.

BMC Genomics. 2009 Jul 7;10 Suppl 1:S6. doi: 10.1186/1471-2164-10-S1-S6.

13.

Catalytic enantioselective intermolecular hydroacylation: rhodium-catalyzed combination of beta-S-aldehydes and 1,3-disubstituted allenes.

Osborne JD, Randell-Sly HE, Currie GS, Cowley AR, Willis MC.

J Am Chem Soc. 2008 Dec 24;130(51):17232-3. doi: 10.1021/ja8069133.

PMID:
19053453
14.

Rhodium-catalysed hydroacylation or reductive aldol reactions: a ligand dependent switch of reactivity.

Osborne JD, Willis MC.

Chem Commun (Camb). 2008 Oct 28;(40):5025-7. doi: 10.1039/b810935d. Epub 2008 Sep 2.

PMID:
18931774
15.

Mining biomedical data using MetaMap Transfer (MMtx) and the Unified Medical Language System (UMLS).

Osborne JD, Lin S, Zhu L, Kibbe WA.

Methods Mol Biol. 2007;408:153-69.

PMID:
18314582
16.

Enantioselective functionalisation of the C-2' position of 1,2,3,4,5-pentamethylazaferrocene via sparteine mediated lithiation: potential new ligands for asymmetric catalysis.

Anderson JC, Osborne JD, Woltering TJ.

Org Biomol Chem. 2008 Jan 21;6(2):330-9. doi: 10.1039/b715323f. Epub 2007 Nov 29.

PMID:
18175002
17.

Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3.

Osborne JD, Da Silva M, Frace AM, Sammons SA, Olsen-Rasmussen M, Upton C, Buller RM, Chen N, Feng Z, Roper RL, Liu J, Pougatcheva S, Chen W, Wohlhueter RM, Esposito JJ.

Vaccine. 2007 Dec 17;25(52):8807-32. Epub 2007 Nov 8.

PMID:
18037545
18.

Interpreting microarray results with gene ontology and MeSH.

Osborne JD, Zhu LJ, Lin SM, Kibbe WA.

Methods Mol Biol. 2007;377:223-42. Review.

PMID:
17634620
19.

Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons.

Mullen GP, Mathews EA, Vu MH, Hunter JW, Frisby DL, Duke A, Grundahl K, Osborne JD, Crowell JA, Rand JB.

Genetics. 2007 Sep;177(1):195-204. Epub 2007 Jul 1.

20.

Other riffs on cooperation are already showing how well a wiki could work.

Osborne JD, Lin S, Kibbe WA.

Nature. 2007 Apr 19;446(7138):856. No abstract available.

PMID:
17443163

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