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Items: 1 to 20 of 567

1.

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.

Lessard S, Beaudoin M, Orkin SH, Bauer DE, Lettre G.

Hum Mol Genet. 2018 Feb 8. doi: 10.1093/hmg/ddy051. [Epub ahead of print]

PMID:
29432581
2.

Regulation of embryonic haematopoietic multipotency by EZH1.

Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ.

Nature. 2018 Jan 25;553(7689):506-510. doi: 10.1038/nature25435. Epub 2018 Jan 17.

PMID:
29342143
3.

Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells.

Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH.

Blood Adv. 2017 Jun 2;1(14):903-914. doi: 10.1182/bloodadvances.2016003798. eCollection 2017 Jun 13.

4.

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, Canver MC.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11257-E11266. doi: 10.1073/pnas.1714640114. Epub 2017 Dec 11.

5.

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.

Vinjamur DS, Bauer DE, Orkin SH.

Br J Haematol. 2017 Nov 28. doi: 10.1111/bjh.15038. [Epub ahead of print] Review.

PMID:
29193029
6.

First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.

Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, Valensisi C, Wang Y, Hawkins RD, Min J, Moon RT, Orkin SH, Baker D, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10125-10130. doi: 10.1073/pnas.1706907114. Epub 2017 Sep 1.

PMID:
28864533
7.

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH.

Cancer Res. 2017 Sep 1;77(17):4613-4625. doi: 10.1158/0008-5472.CAN-17-0216. Epub 2017 Jun 27.

PMID:
28655788
8.

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations.

Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G.

Cell Res. 2017 Jun;27(6):843. doi: 10.1038/cr.2017.78. No abstract available.

9.

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations.

Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G.

Cell Res. 2017 Jun;27(6):842. doi: 10.1038/cr.2017.77. No abstract available.

10.

Erythropoietin signaling regulates heme biosynthesis.

Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.

Elife. 2017 May 29;6. pii: e24767. doi: 10.7554/eLife.24767.

11.

Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells.

Xie Y, Koch ML, Zhang X, Hamblen MJ, Godinho FJ, Fujiwara Y, Xie H, Klusmann JH, Orkin SH, Li Z.

Stem Cells. 2017 Jul;35(7):1773-1785. doi: 10.1002/stem.2627. Epub 2017 Apr 24.

PMID:
28436588
12.

EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.

Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A.

Elife. 2017 Apr 10;6. pii: e24570. doi: 10.7554/eLife.24570.

13.

The 2017 ASPHO distinguished career award goes to Holcombe E. Grier, MD.

Williams DA, Orkin SH.

Pediatr Blood Cancer. 2017 Jun;64 Suppl 1. doi: 10.1002/pbc.26483. No abstract available.

PMID:
28371236
14.

Functional interrogation of non-coding DNA through CRISPR genome editing.

Canver MC, Bauer DE, Orkin SH.

Methods. 2017 May 15;121-122:118-129. doi: 10.1016/j.ymeth.2017.03.008. Epub 2017 Mar 10. Review.

PMID:
28288828
15.

Transcription control by the ENL YEATS domain in acute leukaemia.

Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JE.

Nature. 2017 Mar 9;543(7644):270-274. doi: 10.1038/nature21688. Epub 2017 Mar 1.

16.

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH.

Nat Genet. 2017 Apr;49(4):625-634. doi: 10.1038/ng.3793. Epub 2017 Feb 20.

17.

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. No abstract available.

18.

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations.

Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G.

Cell Res. 2017 Mar;27(3):386-401. doi: 10.1038/cr.2017.17. Epub 2017 Jan 27. Erratum in: Cell Res. 2017 Jun;27(6):842. Cell Res. 2017 Jun;27(6):843.

PMID:
28128194
19.

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F.

Nat Immunol. 2017 Feb;18(2):184-195. doi: 10.1038/ni.3644. Epub 2016 Dec 19.

20.

Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.

Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH.

Cancer Discov. 2016 Nov;6(11):1237-1247. Epub 2016 Sep 14.

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