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J Periodontol. 2002 Jun;73(6):657-63.

Oral pemphigoid masquerading as necrotizing ulcerative gingivitis in a child.

Author information

1
Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, NY 14214, USA. neiders@buffalo.edu

Abstract

BACKGROUND:

Cicatricial pemphigoid (benign mucous membrane pemphigoid) is an autoimmune vesiculobullous disease that affects mucosal tissues of adults and rarely presents in children. Only 9 cases in the English literature have reported cicatricial pemphigoid in children, primarily as oral mucosal lesions. This paper presents a case of childhood cicatricial pemphigoid that clinically manifested as necrotizing ulcerative gingivitis (NUG).

METHODS:

A 9-year-old girl presented with gingival bleeding and discomfort for 2 weeks. NUG was suspected and the patient was treated with antibiotics and an oral hygiene regimen. When the condition did not improve after repeated treatment trials, routine hematoxylin and eosin (H&E) and direct immunofluorescence examinations were performed.

RESULTS:

Microscopic examination of H&E stained sections showed a non-specific ulceration with chronic inflammation. Direct immunofluorescence studies of peri-lesional tissue showed linear deposition of C3 at the basement membrane zone that was consistent with a diagnosis of cicatricial pemphigoid.

CONCLUSION:

Cicatricial pemphigoid is an autoimmune ulcerative condition that is rarely seen in children. Immunofluorescence studies are essential to differentiate this condition from other ulcerative oral lesions.

PMID:
12083540
DOI:
10.1902/jop.2002.73.6.657
[Indexed for MEDLINE]

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