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Items: 1 to 20 of 83

1.

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

Russell RJ, Chachi L, FitzGerald JM, Backer V, Olivenstein R, Titlestad IL, Ulrik CS, Harrison T, Singh D, Chaudhuri R, Leaker B, McGarvey L, Siddiqui S, Wang M, Braddock M, Nordenmark LH, Cohen D, Parikh H, Colice G, Brightling CE; MESOS study investigators.

Lancet Respir Med. 2018 May 18. pii: S2213-2600(18)30201-7. doi: 10.1016/S2213-2600(18)30201-7. [Epub ahead of print]

PMID:
29793857
2.

Interleukin-17A and vascular remodelling in severe asthma; lack of evidence for a direct role.

Panariti A, Baglole CJ, Sanchez V, Eidelman DH, Hussain S, Olivenstein R, Martin JG, Hamid Q.

Clin Exp Allergy. 2018 Apr;48(4):365-378. doi: 10.1111/cea.13093. Epub 2018 Feb 20.

PMID:
29337379
3.

Asthma biomarkers in the age of biologics.

Kim H, Ellis AK, Fischer D, Noseworthy M, Olivenstein R, Chapman KR, Lee J.

Allergy Asthma Clin Immunol. 2017 Nov 17;13:48. doi: 10.1186/s13223-017-0219-4. eCollection 2017. Review.

4.

Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum-induced Allergic Asthma in Nonhuman Primates.

Camateros P, Kanagaratham C, Najdekr L, Holub D, Vrbkova J, Coté L, Fournier J, Gourdon J, Creery D, Olivenstein R, Kopriva F, Adam T, Friedecký D, Džubák P, Hajdúch M, Radzioch D.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):55-65. doi: 10.1165/rcmb.2017-0184OC.

PMID:
28850259
5.

It's better to be lucky … successful management of an acute endobronchial tumour embolism in the ICU: a case report and review of the literature.

Walsh CJ, Olivenstein R, Forget E, Gonzalez AV.

Respirol Case Rep. 2017 Mar 7;5(3):e00225. doi: 10.1002/rcr2.225. eCollection 2017 May.

6.

Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils.

Walsh CJ, Zaihra T, Benedetti A, Fugère C, Olivenstein R, Lemière C, Hamid Q, Martin JG.

Clin Exp Allergy. 2016 Oct;46(10):1291-302. doi: 10.1111/cea.12762. Epub 2016 Jun 27.

PMID:
27214328
7.

Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.

Zaihra T, Walsh CJ, Ahmed S, Fugère C, Hamid QA, Olivenstein R, Martin JG, Benedetti A.

BMC Pulm Med. 2016 May 10;16(1):74. doi: 10.1186/s12890-016-0232-2.

8.

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.

9.

Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M; Asthma Intervention Research 2 Trial Study Group.

J Allergy Clin Immunol. 2013 Dec;132(6):1295-302. doi: 10.1016/j.jaci.2013.08.009. Epub 2013 Aug 30.

10.

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia.

Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, Busse WW, Wenzel S, Wu Y, Datta V, Kolbeck R, Molfino NA.

J Allergy Clin Immunol. 2013 Nov;132(5):1086-1096.e5. doi: 10.1016/j.jaci.2013.05.020. Epub 2013 Jul 16. Erratum in: J Allergy Clin Immunol. 2014 Apr;133(4):1232.

11.

Genetic and histologic evidence for autophagy in asthma pathogenesis.

Poon AH, Chouiali F, Tse SM, Litonjua AA, Hussain SN, Baglole CJ, Eidelman DH, Olivenstein R, Martin JG, Weiss ST, Hamid Q, Laprise C.

J Allergy Clin Immunol. 2012 Feb;129(2):569-71. doi: 10.1016/j.jaci.2011.09.035. Epub 2011 Oct 29. No abstract available.

12.

Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects.

Lemière C, Tremblay C, FitzGerald M, Aaron SD, Leigh R, Boulet LP, Martin JG, Nair P, Olivenstein R, Chaboillez S.

Can Respir J. 2011 Sep-Oct;18(5):278-82.

13.

Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle.

Robins S, Roussel L, Schachter A, Risse PA, Mogas AK, Olivenstein R, Martin JG, Hamid Q, Rousseau S.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):984-90. doi: 10.1165/rcmb.2010-0450OC. Epub 2011 Apr 14.

PMID:
21493783
14.

Asthma in the elderly … Their time is right now.

Olivenstein R, Hamid Q.

Clin Exp Allergy. 2011 Apr;41(4):457-8. doi: 10.1111/j.1365-2222.2011.03702.x. No abstract available.

PMID:
21395874
15.

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial.

Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Laviolette M, Shargill NS, Cox G; AIR Trial Study Group.

BMC Pulm Med. 2011 Feb 11;11:8. doi: 10.1186/1471-2466-11-8.

16.

Montelukast added to fluticasone propionate does not alter inflammation or outcomes.

Djukanović R, Wilson SJ, Moore WC, Koenig SM, Laviolette M, Bleecker ER, Davis WB, Doherty DE, Olivenstein R, Israel E, Kavuru MS, Kleerup E, Reilly DS, Yancey SW, Edwards LD, Stauffer JL, Dorinsky PM, Jarjour NN.

Respir Med. 2010 Oct;104(10):1425-35. doi: 10.1016/j.rmed.2010.04.004. Epub 2010 Aug 14.

17.

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma.

Hassan M, Jo T, Risse PA, Tolloczko B, Lemière C, Olivenstein R, Hamid Q, Martin JG.

J Allergy Clin Immunol. 2010 May;125(5):1037-1045.e3. doi: 10.1016/j.jaci.2010.02.031.

PMID:
20451038
18.

T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma.

Ramos-Barbón D, Fraga-Iriso R, Brienza NS, Montero-Martínez C, Verea-Hernando H, Olivenstein R, Lemiere C, Ernst P, Hamid QA, Martin JG.

Am J Respir Crit Care Med. 2010 Aug 1;182(3):317-24. doi: 10.1164/rccm.200905-0745OC. Epub 2010 Apr 15.

PMID:
20395563
19.

Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples.

Al-Samri MT, Benedetti A, Préfontaine D, Olivenstein R, Lemière C, Nair P, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2010 May;125(5):1161-1163.e4. doi: 10.1016/j.jaci.2010.02.005. Epub 2010 Apr 14. No abstract available.

PMID:
20392486
20.

IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation.

Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S.

J Immunol. 2010 Apr 15;184(8):4531-7. doi: 10.4049/jimmunol.0903162. Epub 2010 Mar 12.

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