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Items: 1 to 20 of 115


Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.

Prokopec SD, Houlahan KE, Sun RX, Watson JD, Yao CQ, Lee J, P'ng C, Pang R, Wu AH, Chong LC, Smith AB, Harding NJ, Moffat ID, Lindén J, Lensu S, Okey AB, Pohjanvirta R, Boutros PC.

BMC Genomics. 2017 Jan 13;18(1):78. doi: 10.1186/s12864-016-3446-z.


2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity.

Watson JD, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R, Boutros PC.

Arch Toxicol. 2017 Jan;91(1):325-338. doi: 10.1007/s00204-016-1720-0. Epub 2016 Apr 30.


Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.

Houlahan KE, Prokopec SD, Sun RX, Moffat ID, Lindén J, Lensu S, Okey AB, Pohjanvirta R, Boutros PC.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):223-31. doi: 10.1016/j.taap.2015.07.018. Epub 2015 Jul 29.


Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.

Houlahan KE, Prokopec SD, Moffat ID, Lindén J, Lensu S, Okey AB, Pohjanvirta R, Boutros PC.

Toxicology. 2015 Feb 3;328:93-101. doi: 10.1016/j.tox.2014.12.016. Epub 2014 Dec 18.


Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity.

Sun RX, Chong LC, Simmons TT, Houlahan KE, Prokopec SD, Watson JD, Moffat ID, Lensu S, Lindén J, P'ng C, Okey AB, Pohjanvirta R, Boutros PC.

BMC Genomics. 2014 Dec 3;15:1053. doi: 10.1186/1471-2164-15-1053.


TCDD dysregulation of 13 AHR-target genes in rat liver.

Watson JD, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R, Boutros PC.

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):445-54. doi: 10.1016/j.taap.2013.12.004. Epub 2013 Dec 16.


Systematic evaluation of medium-throughput mRNA abundance platforms.

Prokopec SD, Watson JD, Waggott DM, Smith AB, Wu AH, Okey AB, Pohjanvirta R, Boutros PC.

RNA. 2013 Jan;19(1):51-62. doi: 10.1261/rna.034710.112. Epub 2012 Nov 20.


Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Yao CQ, Prokopec SD, Watson JD, Pang R, P'ng C, Chong LC, Harding NJ, Pohjanvirta R, Okey AB, Boutros PC.

Toxicol Appl Pharmacol. 2012 Apr 15;260(2):135-45. doi: 10.1016/j.taap.2012.02.001. Epub 2012 Feb 9.


mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components.

Boutros PC, Moffat ID, Okey AB, Pohjanvirta R.

PLoS One. 2011;6(7):e18337. doi: 10.1371/journal.pone.0018337. Epub 2011 Jul 8.


Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity.

Boutros PC, Yao CQ, Watson JD, Wu AH, Moffat ID, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R.

Toxicol Appl Pharmacol. 2011 Mar 1;251(2):119-29. doi: 10.1016/j.taap.2010.12.010. Epub 2011 Jan 5.


Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.

Celius T, Pansoy A, Matthews J, Okey AB, Henderson MC, Krueger SK, Williams DE.

Toxicol Appl Pharmacol. 2010 Aug 15;247(1):60-9. doi: 10.1016/j.taap.2010.05.018. Epub 2010 Jun 4.


Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.

Moffat ID, Boutros PC, Chen H, Okey AB, Pohjanvirta R.

BMC Genomics. 2010 Apr 26;11:263. doi: 10.1186/1471-2164-11-263.


Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.

Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey AB, Harper PA.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3098-107. doi: 10.1158/1055-9965.EPI-08-0341.


Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse.

Boutros PC, Yan R, Moffat ID, Pohjanvirta R, Okey AB.

BMC Genomics. 2008 Sep 16;9:419. doi: 10.1186/1471-2164-9-419.


Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver.

Celius T, Roblin S, Harper PA, Matthews J, Boutros PC, Pohjanvirta R, Okey AB.

Drug Metab Dispos. 2008 Dec;36(12):2499-505. doi: 10.1124/dmd.108.023457. Epub 2008 Sep 2.


Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats.

Franc MA, Moffat ID, Boutros PC, Tuomisto JT, Tuomisto J, Pohjanvirta R, Okey AB.

Arch Toxicol. 2008 Nov;82(11):809-30. doi: 10.1007/s00204-008-0303-0. Epub 2008 May 9. Erratum in: Arch Toxicol. 2008 Nov;82(11):831.


Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue.

Pohjanvirta R, Boutros PC, Moffat ID, Lindén J, Wendelin D, Okey AB.

Toxicol Appl Pharmacol. 2008 Jul 1;230(1):41-56. doi: 10.1016/j.taap.2008.02.002. Epub 2008 Feb 14.


microRNAs in adult rodent liver are refractory to dioxin treatment.

Moffat ID, Boutros PC, Celius T, Lindén J, Pohjanvirta R, Okey AB.

Toxicol Sci. 2007 Oct;99(2):470-87. Epub 2007 Aug 13.


Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity.

Moffat ID, Roblin S, Harper PA, Okey AB, Pohjanvirta R.

Mol Pharmacol. 2007 Oct;72(4):956-66. Epub 2007 Jul 17.

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