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Items: 1 to 20 of 193

1.

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Horswell S, Coussens AK, Barry CE 3rd, O'Garra A, Wilkinson RJ.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E964-E973. doi: 10.1073/pnas.1711853115. Epub 2018 Jan 16.

PMID:
29339504
2.

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis.

Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SH, Anton-Leberre V, O'Garra A, Del Carmen Sasiain M, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.

Am J Respir Crit Care Med. 2017 Nov 21. doi: 10.1164/rccm.201707-1475OC. [Epub ahead of print]

PMID:
29161093
3.

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.

Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A.

J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5.

4.

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.

Lin JW, Sodenkamp J, Cunningham D, Deroost K, Tshitenge TC, McLaughlin S, Lamb TJ, Spencer-Dene B, Hosking C, Ramesar J, Janse CJ, Graham C, O'Garra A, Langhorne J.

Sci Rep. 2017 Feb 3;7:41722. doi: 10.1038/srep41722.

5.

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis.

Marais S, Lai RPJ, Wilkinson KA, Meintjes G, O'Garra A, Wilkinson RJ.

J Infect Dis. 2017 Mar 1;215(5):677-686. doi: 10.1093/infdis/jiw561.

6.

Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role.

O'Garra A, Gabryšová L.

J Immunol. 2016 Dec 1;197(11):4504. No abstract available.

7.

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling.

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M.

J Immunol. 2016 Dec 15;197(12):4714-4726. Epub 2016 Nov 14.

8.

The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis.

Blankley S, Graham CM, Turner J, Berry MP, Bloom CI, Xu Z, Pascual V, Banchereau J, Chaussabel D, Breen R, Santis G, Blankenship DM, Lipman M, O'Garra A.

PLoS One. 2016 Oct 5;11(10):e0162220. doi: 10.1371/journal.pone.0162220. eCollection 2016.

9.

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, Wilkinson RJ.

Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.

10.

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages.

Howes A, Taubert C, Blankley S, Spink N, Wu X, Graham CM, Zhao J, Saraiva M, Ricciardi-Castagnoli P, Bancroft GJ, O'Garra A.

J Immunol. 2016 Oct 1;197(7):2838-53. doi: 10.4049/jimmunol.1501923. Epub 2016 Aug 22.

11.

Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.

Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A.

J Immunol. 2016 Sep 1;197(5):1539-46. No abstract available.

12.

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.

Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A.

J Immunol. 2016 Sep 1;197(5):1531-8. No abstract available.

13.

Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role.

O'Garra A, Gabryšová L.

J Immunol. 2016 Jun 1;196(11):4423-5. doi: 10.4049/jimmunol.1600646. No abstract available. Erratum in: J Immunol. 2016 Dec 1;197(11):4504.

14.

A 380-gene meta-signature of active tuberculosis compared with healthy controls.

Blankley S, Graham CM, Levin J, Turner J, Berry MP, Bloom CI, Xu Z, Pascual V, Banchereau J, Chaussabel D, Breen R, Santis G, Blankenship DM, Lipman M, O'Garra A.

Eur Respir J. 2016 Jun;47(6):1873-6. doi: 10.1183/13993003.02121-2015. Epub 2016 Apr 13. No abstract available.

15.

Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling.

Pitt JM, Blankley S, Potempa K, Graham CM, Moreira-Teixeira L, McNab FW, Howes A, Stavropoulos E, Pascual V, Banchereau J, Chaussabel D, O'Garra A.

PLoS One. 2016 Feb 26;11(2):e0150251. doi: 10.1371/journal.pone.0150251. eCollection 2016.

16.

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.

Lai RP, Meintjes G, Wilkinson KA, Graham CM, Marais S, Van der Plas H, Deffur A, Schutz C, Bloom C, Munagala I, Anguiano E, Goliath R, Maartens G, Banchereau J, Chaussabel D, O'Garra A, Wilkinson RJ.

Nat Commun. 2015 Sep 24;6:8451. doi: 10.1038/ncomms9451.

17.

The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease.

Conejero L, Potempa K, Graham CM, Spink N, Blankley S, Salguero FJ, Pankla-Sranujit R, Khaenam P, Banchereau JF, Pascual V, Chaussabel D, Lertmemongkolchai G, O'Garra A, Bancroft GJ.

J Immunol. 2015 Oct 1;195(7):3248-3261. doi: 10.4049/jimmunol.1500641. Epub 2015 Aug 26.

18.

The human immune response to tuberculosis and its treatment: a view from the blood.

Cliff JM, Kaufmann SH, McShane H, van Helden P, O'Garra A.

Immunol Rev. 2015 Mar;264(1):88-102. doi: 10.1111/imr.12269. Review.

19.

Type I interferons in infectious disease.

McNab F, Mayer-Barber K, Sher A, Wack A, O'Garra A.

Nat Rev Immunol. 2015 Feb;15(2):87-103. doi: 10.1038/nri3787. Review.

PMID:
25614319
20.

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.

McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N, Saraiva M, O'Garra A.

J Immunol. 2014 Oct 1;193(7):3600-12. doi: 10.4049/jimmunol.1401088. Epub 2014 Sep 3.

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