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CASAnova: a multiclass support vector machine model for the classification of human sperm motility patterns.

Goodson SG, White S, Stevans AM, Bhat S, Kao CY, Jaworski S, Marlowe TR, Kohlmeier M, McMillan L, Zeisel SH, O'Brien DA.

Biol Reprod. 2017 Nov 1;97(5):698-708. doi: 10.1093/biolre/iox120.


Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes.

Huang Z, Danshina PV, Mohr K, Qu W, Goodson SG, O'Connell TM, O'Brien DA.

Biol Reprod. 2017 Oct 1;97(4):586-597. doi: 10.1093/biolre/iox103.


Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.

Shorter JR, Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L, O'Brien DA, Villena FP.

Genetics. 2017 Jun;206(2):557-572. doi: 10.1534/genetics.116.199596.


Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.

Danshina PV, Qu W, Temple BR, Rojas RJ, Miley MJ, Machius M, Betts L, O'Brien DA.

Mol Hum Reprod. 2016 Jun;22(6):410-26. doi: 10.1093/molehr/gaw016. Epub 2016 Feb 26.


The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction.

Odet F, Pan W, Bell TA, Goodson SG, Stevans AM, Yun Z, Aylor DL, Kao CY, McMillan L, de Villena FP, O'Brien DA.

G3 (Bethesda). 2015 Oct 19;5(12):2671-83. doi: 10.1534/g3.115.020172. Erratum in: G3 (Bethesda). 2016 Mar;6(3):767.


A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.


Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation.

Goodson SG, Qiu Y, Sutton KA, Xie G, Jia W, O'Brien DA.

Biol Reprod. 2012 Sep 28;87(3):75. Print 2012 Sep.


The genome architecture of the Collaborative Cross mouse genetic reference population.

Collaborative Cross Consortium.

Genetics. 2012 Feb;190(2):389-401. doi: 10.1534/genetics.111.132639.


Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS).

Sexton JZ, Danshina PV, Lamson DR, Hughes M, House AJ, Yeh LA, O'Brien DA, Williams KP.

Curr Chem Genomics. 2011;5:30-41. doi: 10.2174/1875397301105010030. Epub 2011 Jul 4.


Classification of mouse sperm motility patterns using an automated multiclass support vector machines model.

Goodson SG, Zhang Z, Tsuruta JK, Wang W, O'Brien DA.

Biol Reprod. 2011 Jun;84(6):1207-15. doi: 10.1095/biolreprod.110.088989. Epub 2011 Feb 23.


Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells.

Lamson DR, House AJ, Danshina PV, Sexton JZ, Sanyang K, O'Brien DA, Yeh LA, Williams KP.

Protein Expr Purif. 2011 Jan;75(1):104-13. doi: 10.1016/j.pep.2010.09.003. Epub 2010 Sep 7. Erratum in: Protein Expr Purif. 2011 Apr;76(2):264.


Speriolin is a novel human and mouse sperm centrosome protein.

Goto M, O'Brien DA, Eddy EM.

Hum Reprod. 2010 Aug;25(8):1884-94. doi: 10.1093/humrep/deq138. Epub 2010 Jun 11.


Frequent and recent retrotransposition of orthologous genes plays a role in the evolution of sperm glycolytic enzymes.

Vemuganti SA, de Villena FP, O'Brien DA.

BMC Genomics. 2010 May 6;11:285. doi: 10.1186/1471-2164-11-285.


Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice.

Danshina PV, Geyer CB, Dai Q, Goulding EH, Willis WD, Kitto GB, McCarrey JR, Eddy EM, O'Brien DA.

Biol Reprod. 2010 Jan;82(1):136-45. doi: 10.1095/biolreprod.109.079699. Epub 2009 Sep 16.


A-kinase anchoring protein 4 has a conserved role in mammalian spermatogenesis.

Hu Y, Yu H, Pask AJ, O'Brien DA, Shaw G, Renfree MB.

Reproduction. 2009 Apr;137(4):645-53. doi: 10.1530/REP-08-0337. Epub 2009 Jan 12.


Bicarbonate-induced phosphorylation of p270 protein in mouse sperm by cAMP-dependent protein kinase.

Kaneto M, Krisfalusi M, Eddy EM, O'Brien DA, Miki K.

Mol Reprod Dev. 2008 Jun;75(6):1045-53. doi: 10.1002/mrd.20839.


X-ray analysis of phosphoglycerate kinase 2, a sperm-specific isoform from Mus musculus.

Sawyer GM, Monzingo AF, Poteet EC, O'Brien DA, Robertus JD.

Proteins. 2008 May 15;71(3):1134-44.


Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm.

Nakamura N, Shibata H, O'Brien DA, Mori C, Eddy EM.

Mol Reprod Dev. 2008 Apr;75(4):632-40.


Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition.

Vemuganti SA, Bell TA, Scarlett CO, Parker CE, de Villena FP, O'Brien DA.

Dev Biol. 2007 Sep 1;309(1):18-31. Epub 2007 Jun 18.

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