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Items: 1 to 20 of 25

1.

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

Hauser SL, Bar-Or A, Comi G, Giovannoni G, Hartung HP, Hemmer B, Lublin F, Montalban X, Rammohan KW, Selmaj K, Traboulsee A, Wolinsky JS, Arnold DL, Klingelschmitt G, Masterman D, Fontoura P, Belachew S, Chin P, Mairon N, Garren H, Kappos L; OPERA I and OPERA II Clinical Investigators.

N Engl J Med. 2017 Jan 19;376(3):221-234. doi: 10.1056/NEJMoa1601277. Epub 2016 Dec 21.

2.

Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line.

Bialesova L, Novotna A, Macejova D, Brtko J, Dvorak Z.

Gen Physiol Biophys. 2015 Jul;34(3):331-4. doi: 10.4149/gpb_2015008. Epub 2015 Apr 30.

PMID:
25926549
3.

Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity.

Bartonkova I, Novotna A, Dvorak Z.

PLoS One. 2015 Mar 26;10(3):e0121316. doi: 10.1371/journal.pone.0121316. eCollection 2015.

4.

Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells.

Novotná A, Krasulová K, Bartoňková I, Korhoňová M, Bachleda P, Anzenbacher P, Dvořák Z.

PLoS One. 2014 Oct 24;9(10):e111286. doi: 10.1371/journal.pone.0111286. eCollection 2014.

5.

Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid receptor and pregnane X receptor axis.

Novotna A, Dvorak Z.

PLoS One. 2014 Aug 20;9(8):e105580. doi: 10.1371/journal.pone.0105580. eCollection 2014.

6.

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor.

Novotna A, Korhonova M, Bartonkova I, Soshilov AA, Denison MS, Bogdanova K, Kolar M, Bednar P, Dvorak Z.

PLoS One. 2014 Jul 7;9(7):e101832. doi: 10.1371/journal.pone.0101832. eCollection 2014.

7.

Differential effects of omeprazole and lansoprazole enantiomers on aryl hydrocarbon receptor in human hepatocytes and cell lines.

Novotna A, Srovnalova A, Svecarova M, Korhonova M, Bartonkova I, Dvorak Z.

PLoS One. 2014 Jun 2;9(6):e98711. doi: 10.1371/journal.pone.0098711. eCollection 2014.

8.

Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines.

Novotna A, Kamenickova A, Pecova M, Korhonova M, Bartonkova I, Dvorak Z.

Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.

PMID:
24316275
9.

Influence of gold(I) complexes involving adenine derivatives on major drug-drug interaction pathway.

Dvořák Z, Novotná A, Vančo J, Trávníček Z.

Toxicol In Vitro. 2013 Dec;27(8):2331-4. doi: 10.1016/j.tiv.2013.10.008. Epub 2013 Oct 21.

PMID:
24157406
10.

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.

Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S.

J Neurol. 2013 Apr;260(4):984-97. doi: 10.1007/s00415-012-6739-4. Epub 2012 Nov 21.

PMID:
23180178
11.

Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation.

Novotna A, Pavek P, Dvorak Z.

Eur J Pharm Sci. 2012 Dec 18;47(5):842-7. doi: 10.1016/j.ejps.2012.10.003. Epub 2012 Oct 23.

PMID:
23089292
12.

Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).

Novotna A, Doricakova A, Pavek P, Dvorak Z.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Sep;157(3):214-21. doi: 10.5507/bp.2012.075. Epub 2012 Sep 5.

13.

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.

Doricakova A, Novotna A, Vrzal R, Pavek P, Dvorak Z.

Arch Toxicol. 2013 Feb;87(2):291-301. doi: 10.1007/s00204-012-0937-9. Epub 2012 Sep 14.

PMID:
22976785
14.

Myotonic dystrophy type 2 and multiple sclerosis: case report.

Ehler E, Novotná A, Mareš M, Mušová Z, Mrklovský M.

Clin Neurol Neurosurg. 2012 Dec;114(10):1358-60. doi: 10.1016/j.clineuro.2012.03.034. Epub 2012 Apr 11. No abstract available.

PMID:
22502787
15.

Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization.

Novotna A, Pavek P, Dvorak Z.

Environ Sci Technol. 2011 Dec 1;45(23):10133-9. doi: 10.1021/es2029334. Epub 2011 Nov 2.

PMID:
22017252
16.

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.

Novotna A, Doricakova A, Vrzal R, Pavek P, Dvorak Z.

Eur J Pharmacol. 2011 Nov 1;669(1-3):45-50. doi: 10.1016/j.ejphar.2011.07.049. Epub 2011 Aug 19.

PMID:
21871880
17.

Supportive strategies to improve adherence to IFN β-1b in multiple sclerosis--results of the βPlus observational cohort study.

Pozzilli C, Schweikert B, Ecari U, Oentrich W; BetaPlus Study group.

J Neurol Sci. 2011 Aug 15;307(1-2):120-6. doi: 10.1016/j.jns.2011.04.026. Epub 2011 Jun 1.

PMID:
21636099
18.

A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.

Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P; Sativex Spasticity Study Group.

Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x. Epub 2011 Mar 1.

PMID:
21362108
19.

Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?

Vrzal R, Doricakova A, Novotna A, Bachleda P, Bitman M, Pavek P, Dvorak Z.

Toxicol Lett. 2011 Feb 5;200(3):146-53. doi: 10.1016/j.toxlet.2010.11.008. Epub 2010 Nov 27.

PMID:
21115105
20.

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells.

Novotna A, Doricakova A, Vrzal R, Maurel P, Pavek P, Dvorak Z.

Eur J Pharm Sci. 2010 Oct 9;41(2):276-80. doi: 10.1016/j.ejps.2010.06.019. Epub 2010 Jul 3.

PMID:
20599501

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