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Items: 1 to 20 of 236

1.

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.

PMID:
28916735
2.

Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks.

Saa PA, Nielsen LK.

Biotechnol Adv. 2017 Dec;35(8):981-1003. doi: 10.1016/j.biotechadv.2017.09.005. Epub 2017 Sep 13. Review.

PMID:
28916392
3.

Plant genome-scale reconstruction: from single cell to multi-tissue modelling and omics analyses.

Gomes de Oliveira Dal'Molin C, Nielsen LK.

Curr Opin Biotechnol. 2017 Aug 11;49:42-48. doi: 10.1016/j.copbio.2017.07.009. [Epub ahead of print] Review.

PMID:
28806583
4.

Cell-free pipeline for discovery of thermotolerant xylanases and endo-1,4-β-glucanases.

Gagoski D, Shi Z, Nielsen LK, Vickers CE, Mahler S, Speight R, Johnston WA, Alexandrov K.

J Biotechnol. 2017 Oct 10;259:191-198. doi: 10.1016/j.jbiotec.2017.07.014. Epub 2017 Jul 17.

PMID:
28728936
5.

Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase.

Gonzalez-Garcia RA, McCubbin T, Wille A, Plan M, Nielsen LK, Marcellin E.

Microb Cell Fact. 2017 Jul 17;16(1):121. doi: 10.1186/s12934-017-0735-4.

6.

Maintenance of ATP Homeostasis Triggers Metabolic Shifts in Gas-Fermenting Acetogens.

Valgepea K, de Souza Pinto Lemgruber R, Meaghan K, Palfreyman RW, Abdalla T, Heijstra BD, Behrendorff JB, Tappel R, Köpke M, Simpson SD, Nielsen LK, Marcellin E.

Cell Syst. 2017 May 24;4(5):505-515.e5. doi: 10.1016/j.cels.2017.04.008. Epub 2017 May 17.

PMID:
28527885
7.

Arginine deiminase pathway provides ATP and boosts growth of the gas-fermenting acetogen Clostridium autoethanogenum.

Valgepea K, Loi KQ, Behrendorff JB, Lemgruber RSP, Plan M, Hodson MP, Köpke M, Nielsen LK, Marcellin E.

Metab Eng. 2017 May;41:202-211. doi: 10.1016/j.ymben.2017.04.007. Epub 2017 Apr 23.

PMID:
28442386
8.

Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells.

Orellana CA, Marcellin E, Gray PP, Nielsen LK.

Biotechnol Bioeng. 2017 Aug;114(8):1825-1836. doi: 10.1002/bit.26316. Epub 2017 May 8.

PMID:
28436007
9.

A systematic review of health-related quality of life in longitudinal studies of myeloma patients.

Nielsen LK, Jarden M, Andersen CL, Frederiksen H, Abildgaard N.

Eur J Haematol. 2017 Jul;99(1):3-17. doi: 10.1111/ejh.12882. Epub 2017 Apr 25. Review.

PMID:
28322018
10.

Coupling gene regulatory patterns to bioprocess conditions to optimize synthetic metabolic modules for improved sesquiterpene production in yeast.

Peng B, Plan MR, Carpenter A, Nielsen LK, Vickers CE.

Biotechnol Biofuels. 2017 Feb 21;10:43. doi: 10.1186/s13068-017-0728-x. eCollection 2017.

11.

A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae.

Peng B, Plan MR, Chrysanthopoulos P, Hodson MP, Nielsen LK, Vickers CE.

Metab Eng. 2017 Jan;39:209-219. doi: 10.1016/j.ymben.2016.12.003. Epub 2016 Dec 8.

PMID:
27939849
12.

Hand bone loss in early rheumatoid arthritis during a methotrexate-based treat-to-target strategy with or without adalimumab-a substudy of the optimized treatment algorithm in early RA (OPERA) trial.

Ørnbjerg LM, Østergaard M, Jensen T, Hørslev-Petersen K, Stengaard-Pedersen K, Junker P, Ellingsen T, Ahlquist P, Lindegaard H, Linauskas A, Schlemmer A, Dam MY, Hansen I, Lottenburger T, Ammitzbøll CG, Jørgensen A, Krintel SB, Raun J, Hetland ML; OPERA Study Group, Slot O, Nielsen LK, Skjødt H, Majgaard O, Lorenzen T, Horn HC, Kowalski M, Johansen IL, Pedersen PM, Manilo N, Bliddal H.

Clin Rheumatol. 2017 Apr;36(4):781-789. doi: 10.1007/s10067-016-3489-1. Epub 2016 Dec 5.

PMID:
27921185
13.

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE.

Cell Syst. 2016 Nov 23;3(5):434-443.e8. doi: 10.1016/j.cels.2016.10.020.

14.

Improved production of propionic acid using genome shuffling.

Luna-Flores CH, Palfreyman RW, Krömer JO, Nielsen LK, Marcellin E.

Biotechnol J. 2017 Feb;12(2). doi: 10.1002/biot.201600120. Epub 2016 Oct 20.

PMID:
27676587
15.

In vitro production of baculoviruses: identifying host and virus genes associated with high productivity.

Nguyen Q, Tb Tran T, Chan LC, Nielsen LK, Reid S.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9239-9253. Epub 2016 Sep 9.

PMID:
27613424
16.

Metabolic Reconstruction of Setaria italica: A Systems Biology Approach for Integrating Tissue-Specific Omics and Pathway Analysis of Bioenergy Grasses.

de Oliveira Dal'Molin CG, Orellana C, Gebbie L, Steen J, Hodson MP, Chrysanthopoulos P, Plan MR, McQualter R, Palfreyman RW, Nielsen LK.

Front Plant Sci. 2016 Aug 10;7:1138. doi: 10.3389/fpls.2016.01138. eCollection 2016.

17.

Fast-SNP: a fast matrix pre-processing algorithm for efficient loopless flux optimization of metabolic models.

Saa PA, Nielsen LK.

Bioinformatics. 2016 Dec 15;32(24):3807-3814. Epub 2016 Aug 24.

18.

Spliced synthetic genes as internal controls in RNA sequencing experiments.

Hardwick SA, Chen WY, Wong T, Deveson IW, Blackburn J, Andersen SB, Nielsen LK, Mattick JS, Mercer TR.

Nat Methods. 2016 Sep;13(9):792-8. doi: 10.1038/nmeth.3958. Epub 2016 Aug 8.

PMID:
27502218
19.

Representing genetic variation with synthetic DNA standards.

Deveson IW, Chen WY, Wong T, Hardwick SA, Andersen SB, Nielsen LK, Mattick JS, Mercer TR.

Nat Methods. 2016 Sep;13(9):784-91. doi: 10.1038/nmeth.3957. Epub 2016 Aug 8.

PMID:
27502217
20.

Tetanus toxin production is triggered by the transition from amino acid consumption to peptides.

Licona-Cassani C, Steen JA, Zaragoza NE, Moonen G, Moutafis G, Hodson MP, Power J, Nielsen LK, Marcellin E.

Anaerobe. 2016 Oct;41:113-124. doi: 10.1016/j.anaerobe.2016.07.006. Epub 2016 Aug 1.

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