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Items: 17

1.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

2.

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.

Cobo I, Martinelli P, Flández M, Bakiri L, Zhang M, Carrillo-de-Santa-Pau E, Jia J, Sánchez-Arévalo Lobo VJ, Megías D, Felipe I, Del Pozo N, Millán I, Thommesen L, Bruland T, Olson SH, Smith J, Schoonjans K, Bamlet WR, Petersen GM, Malats N, Amundadottir LT, Wagner EF, Real FX.

Nature. 2018 Feb 22;554(7693):533-537. doi: 10.1038/nature25751. Epub 2018 Feb 14.

3.
4.

Antiproliferation activity of a small molecule repressor of liver receptor homolog 1.

Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR.

Mol Pharmacol. 2015 Feb;87(2):296-304. doi: 10.1124/mol.114.095554. Epub 2014 Dec 3.

5.

Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.

Huang SC, Lee CT, Chung BC.

Sci Signal. 2014 Feb 25;7(314):ra20. doi: 10.1126/scisignal.2004786.

PMID:
24570488
6.

The effects of aging on the expression of Wnt pathway genes in mouse tissues.

Hofmann JW, McBryan T, Adams PD, Sedivy JM.

Age (Dordr). 2014 Jun;36(3):9618. doi: 10.1007/s11357-014-9618-3. Epub 2014 Feb 1.

7.

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Flandez M, Cendrowski J, Cañamero M, Salas A, del Pozo N, Schoonjans K, Real FX.

Gut. 2014 Apr;63(4):647-55. doi: 10.1136/gutjnl-2012-304381. Epub 2013 Apr 18.

PMID:
23598351
8.

Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity.

Burris TP, Busby SA, Griffin PR.

Chem Biol. 2012 Jan 27;19(1):51-9. doi: 10.1016/j.chembiol.2011.12.011. Review.

9.

The interaction of hepatic lipid and glucose metabolism in liver diseases.

Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A.

J Hepatol. 2012 Apr;56(4):952-64. doi: 10.1016/j.jhep.2011.08.025. Epub 2011 Dec 13. Review.

10.

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation.

Hostettler N, Bianchi P, Gennari-Moser C, Kassahn D, Schoonjans K, Corazza N, Brunner T.

Allergy. 2012 Feb;67(2):227-34. doi: 10.1111/j.1398-9995.2011.02749.x. Epub 2011 Nov 24.

PMID:
22111694
11.

New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts.

Li D, Abbruzzese JL.

Clin Cancer Res. 2010 Sep 1;16(17):4313-8. doi: 10.1158/1078-0432.CCR-09-1942. Epub 2010 Jul 20.

12.

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Jänne OA, Gustafsson JA, Steffensen KR, Treuter E.

Genes Dev. 2010 Feb 15;24(4):381-95. doi: 10.1101/gad.545110.

13.

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, Schoonjans K.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13098-103. Epub 2007 Aug 1.

15.

Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response.

Venteclef N, Smith JC, Goodwin B, Delerive P.

Mol Cell Biol. 2006 Sep;26(18):6799-807.

16.

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, Auwerx J.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2058-62. Epub 2005 Jan 31.

17.

Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells.

Antonio V, Janvier B, Brouillet A, Andreani M, Raymondjean M.

Biochem J. 2003 Dec 1;376(Pt 2):351-60.

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