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Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.

Trenteseaux C, Gaston AT, Aguesse A, Poupeau G, de Coppet P, Andriantsitohaina R, Laschet J, Amarger V, Krempf M, Nobecourt-Dupuy E, Ouguerram K.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2053-2063. doi: 10.1161/ATVBAHA.117.309923. Epub 2017 Sep 21.


Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD.

Nat Commun. 2016 Feb 18;7:10713. doi: 10.1038/ncomms10713.


Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype.

Cabrerizo R, Castaño GO, Burgueño AL, Fernández Gianotti T, Gonzalez Lopez Ledesma MM, Flichman D, Pirola CJ, Sookoian S.

PLoS One. 2014 Jan 31;9(1):e87697. doi: 10.1371/journal.pone.0087697. eCollection 2014.


Polymorphisms in the organic anion transporting polypeptide genes influence liver parenchymal enhancement in gadoxetic acid-enhanced MRI.

Okubo H, Ando H, Kokubu S, Miyazaki A, Watanabe S, Fujimura A.

Pharmacogenomics. 2013 Oct;14(13):1573-82. doi: 10.2217/pgs.13.132.


Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans.

Heni M, Wagner R, Ketterer C, Böhm A, Linder K, Machicao F, Machann J, Schick F, Hennige AM, Stefan N, Häring HU, Fritsche A, Staiger H.

J Clin Endocrinol Metab. 2013 Jul;98(7):E1224-9. doi: 10.1210/jc.2013-1177. Epub 2013 May 2.


A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease.

Iwata R, Baur K, Stieger B, Mertens JC, Daly AK, Frei P, Braun J, Vergopoulos A, Stickel F, Sabrane K, Martin IV, Schmitt J, Goetze O, Day CP, Müllhaupt B, Geier A; Swiss Hepatitis C Cohort Study Group.

Clin Sci (Lond). 2011 Apr;120(7):287-96. doi: 10.1042/CS20100246.


Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients.

Journe F, Durbecq V, Chaboteaux C, Rouas G, Laurent G, Nonclercq D, Sotiriou C, Body JJ, Larsimont D.

Breast Cancer Res Treat. 2009 Jun;115(3):523-35. doi: 10.1007/s10549-008-0094-2. Epub 2008 Jun 19.


Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis.

Yuan ZB, Han TQ, Jiang ZY, Fei J, Zhang Y, Qin J, Tian ZJ, Shang J, Jiang ZH, Cai XX, Jiang Y, Zhang SD.

World J Gastroenterol. 2005 Apr 14;11(14):2109-16.


Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies.

Nishimura M, Naito S, Yokoi T.

Drug Metab Pharmacokinet. 2004 Apr;19(2):135-49.

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