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Items: 1 to 20 of 57

1.

Monitoring the Transcriptional Activity of Human Endogenous Retroviral HERV-W Family Using PNA Strand Invasion into Double-Stranded DNA.

Machnik G, Skudrzyk E, Bułdak Ł, Ruczyński J, Kozłowska A, Mucha P, Rekowski P, Szkróbka W, Basiak M, Bołdys A, Sławska H, Okopień B.

Mol Biotechnol. 2018 Feb;60(2):124-133. doi: 10.1007/s12033-017-0057-0.

2.

Multiple sclerosis-associated retrovirus, Epstein-Barr virus, and vitamin D status in patients with relapsing remitting multiple sclerosis.

Mostafa A, Jalilvand S, Shoja Z, Nejati A, Shahmahmoodi S, Sahraian MA, Marashi SM.

J Med Virol. 2017 Jul;89(7):1309-1313. doi: 10.1002/jmv.24774. Epub 2017 Mar 8.

PMID:
28165135
3.

The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family.

Machnik G, Bułdak Ł, Ruczyński J, Gąsior T, Huzarska M, Belowski D, Alenowicz M, Mucha P, Rekowski P, Okopień B.

J Mol Recognit. 2017 May;30(5). doi: 10.1002/jmr.2600. Epub 2016 Dec 6.

PMID:
27921323
4.

A survey of endogenous retrovirus (ERV) sequences in the vicinity of multiple sclerosis (MS)-associated single nucleotide polymorphisms (SNPs).

Brütting C, Emmer A, Kornhuber M, Staege MS.

Mol Biol Rep. 2016 Aug;43(8):827-36. doi: 10.1007/s11033-016-4004-0. Epub 2016 May 12.

PMID:
27169423
5.

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment.

Madeira A, Burgelin I, Perron H, Curtin F, Lang AB, Faucard R.

J Neuroimmunol. 2016 Feb 15;291:29-38. doi: 10.1016/j.jneuroim.2015.12.006. Epub 2015 Dec 11.

6.

Treatment against human endogenous retrovirus: a possible personalized medicine approach for multiple sclerosis.

Curtin F, Perron H, Faucard R, Porchet H, Lang AB.

Mol Diagn Ther. 2015 Oct;19(5):255-65. doi: 10.1007/s40291-015-0166-z.

PMID:
26376649
7.

A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-up.

Derfuss T, Curtin F, Guebelin C, Bridel C, Rasenack M, Matthey A, Du Pasquier R, Schluep M, Desmeules J, Lang AB, Perron H, Faucard R, Porchet H, Hartung HP, Kappos L, Lalive PH.

J Neuroimmunol. 2015 Aug 15;285:68-70. doi: 10.1016/j.jneuroim.2015.05.019. Epub 2015 May 20.

PMID:
26198921
8.

A Novel, Highly Selective RT-QPCR Method for Quantification of MSRV Using PNA Clamping Syncytin-1 (ERVWE1).

Machnik G, Skudrzyk E, Bułdak Ł, Łabuzek K, Ruczyński J, Alenowicz M, Rekowski P, Nowak PJ, Okopień B.

Mol Biotechnol. 2015 Sep;57(9):801-13. doi: 10.1007/s12033-015-9873-2.

9.

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4.

Duperray A, Barbe D, Raguenez G, Weksler BB, Romero IA, Couraud PO, Perron H, Marche PN.

Int Immunol. 2015 Nov;27(11):545-53. doi: 10.1093/intimm/dxv025. Epub 2015 May 8.

10.

The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade.

Kremer D, Förster M, Schichel T, Göttle P, Hartung HP, Perron H, Küry P.

Mult Scler. 2015 Aug;21(9):1200-3. doi: 10.1177/1352458514560926. Epub 2014 Dec 5.

PMID:
25480862
11.

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein.

Curtin F, Perron H, Kromminga A, Porchet H, Lang AB.

MAbs. 2015;7(1):265-75. doi: 10.4161/19420862.2014.985021.

12.

A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients.

Derfuss T, Curtin F, Guebelin C, Bridel C, Rasenack M, Matthey A, Du Pasquier R, Schluep M, Desmeules J, Lang AB, Perron H, Faucard R, Porchet H, Hartung HP, Kappos L, Lalive PH.

Mult Scler. 2015 Jun;21(7):885-93. doi: 10.1177/1352458514554052. Epub 2014 Nov 12.

PMID:
25392325
13.

HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4: inference for neuroAIDS.

Uleri E, Mei A, Mameli G, Poddighe L, Serra C, Dolei A.

AIDS. 2014 Nov 28;28(18):2659-70. doi: 10.1097/QAD.0000000000000477.

PMID:
25250834
14.

A peptide nucleic acid (PNA)-mediated polymerase chain reaction clamping allows the selective inhibition of the ERVWE1 gene amplification.

Machnik G, Łabuzek K, Skudrzyk E, Rekowski P, Ruczyński J, Wojciechowska M, Mucha P, Giri S, Okopień B.

Mol Cell Probes. 2014 Oct-Dec;28(5-6):237-41. doi: 10.1016/j.mcp.2014.04.003. Epub 2014 May 9.

PMID:
24814867
15.

HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV.

García-Montojo M, de la Hera B, Varadé J, de la Encarnación A, Camacho I, Domínguez-Mozo M, Árias-Leal A, García-Martínez A, Casanova I, Izquierdo G, Lucas M, Fedetz M, Alcina A, Arroyo R, Matesanz F, Urcelay E, Alvarez-Lafuente R.

Retrovirology. 2014 Jan 9;11:2. doi: 10.1186/1742-4690-11-2.

16.

Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis.

Dolei A, Garson JA, Arru G, Clerici M, Germi R, Marche PN, Perron H.

J Neuroimmunol. 2014 Jan 15;266(1-2):87-8. doi: 10.1016/j.jneuroim.2013.11.009. Epub 2013 Dec 6. No abstract available.

PMID:
24355750
17.

Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis: a literature review.

Hon GM, Erasmus RT, Matsha T.

J Neuroimmunol. 2013 Oct 15;263(1-2):8-12. doi: 10.1016/j.jneuroim.2013.08.005. Epub 2013 Aug 15. Review.

PMID:
23993654
18.

The DNA copy number of human endogenous retrovirus-W (MSRV-type) is increased in multiple sclerosis patients and is influenced by gender and disease severity.

Garcia-Montojo M, Dominguez-Mozo M, Arias-Leal A, Garcia-Martinez Á, De las Heras V, Casanova I, Faucard R, Gehin N, Madeira A, Arroyo R, Curtin F, Alvarez-Lafuente R, Perron H.

PLoS One. 2013;8(1):e53623. doi: 10.1371/journal.pone.0053623. Epub 2013 Jan 7.

19.

GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus: a first-in-humans randomized clinical study.

Curtin F, Lang AB, Perron H, Laumonier M, Vidal V, Porchet HC, Hartung HP.

Clin Ther. 2012 Dec;34(12):2268-78. doi: 10.1016/j.clinthera.2012.11.006. Epub 2012 Nov 29.

PMID:
23200102
20.

Human endogenous retroviruses in multiple sclerosis: potential for novel neuro-pharmacological research.

Ryan FP.

Curr Neuropharmacol. 2011 Jun;9(2):360-9. doi: 10.2174/157015911795596568.

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