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Items: 1 to 20 of 156

1.

Klotho controls the brain-immune system interface in the choroid plexus.

Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11388-E11396. doi: 10.1073/pnas.1808609115. Epub 2018 Nov 9.

2.

The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease.

Tosh JL, Rickman M, Rhymes E, Norona FE, Clayton E, Mucke L, Isaacs AM, Fisher EMC, Wiseman FK.

Version 2. Wellcome Open Res. 2018 Oct 10 [revised 2018 Jan 1];2:84. doi: 10.12688/wellcomeopenres.12237.2. eCollection 2017.

3.

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K.

Nat Immunol. 2018 Nov;19(11):1212-1223. doi: 10.1038/s41590-018-0232-x. Epub 2018 Oct 15.

PMID:
30323343
4.

The mouse as a model for neuropsychiatric drug development.

Howe JR 6th, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ.

Curr Biol. 2018 Sep 10;28(17):R909-R914. doi: 10.1016/j.cub.2018.07.046.

PMID:
30205056
5.

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.

PMID:
30053424
6.

Neuronal levels and sequence of tau modulate the power of brain rhythms.

Das M, Maeda S, Hu B, Yu GQ, Guo W, Lopez I, Yu X, Tai C, Wang X, Mucke L.

Neurobiol Dis. 2018 Sep;117:181-188. doi: 10.1016/j.nbd.2018.05.020. Epub 2018 May 31.

PMID:
29859869
7.

Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.

Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ.

Neuron. 2018 Apr 4;98(1):75-89.e5. doi: 10.1016/j.neuron.2018.02.029. Epub 2018 Mar 15.

PMID:
29551491
8.

Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L.

Neurobiol Dis. 2018 Feb;110:29-36. doi: 10.1016/j.nbd.2017.10.014. Epub 2017 Oct 31.

PMID:
29100987
9.

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.

Miyamoto T, Stein L, Thomas R, Djukic B, Taneja P, Knox J, Vossel K, Mucke L.

Mol Neurodegener. 2017 May 19;12(1):41. doi: 10.1186/s13024-017-0176-x.

10.

Network abnormalities and interneuron dysfunction in Alzheimer disease.

Palop JJ, Mucke L.

Nat Rev Neurosci. 2016 Dec;17(12):777-792. doi: 10.1038/nrn.2016.141. Epub 2016 Nov 10. Review.

PMID:
27829687
11.

Tau Phosphorylation-Much More than a Biomarker.

Maeda S, Mucke L.

Neuron. 2016 Oct 19;92(2):265-267. doi: 10.1016/j.neuron.2016.10.011.

12.

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease.

Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS.

Ann Neurol. 2016 Dec;80(6):858-870. doi: 10.1002/ana.24794. Epub 2016 Nov 7.

13.

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.

Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L.

EMBO Rep. 2016 Apr;17(4):530-51. doi: 10.15252/embr.201541438. Epub 2016 Mar 1.

14.

Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.

Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L.

Ann Clin Transl Neurol. 2015 Oct 16;2(11):1012-28. doi: 10.1002/acn3.257. eCollection 2015 Nov.

15.

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.

Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L.

Nat Commun. 2015 Nov 30;6:8897. doi: 10.1038/ncomms9897.

16.
17.

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.

Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L.

Nat Neurosci. 2015 Aug;18(8):1183-9. doi: 10.1038/nn.4067. Epub 2015 Jul 20.

PMID:
26192747
18.

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L.

J Cell Biol. 2015 May 11;209(3):419-33. doi: 10.1083/jcb.201407065.

19.

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.

Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K.

Cell Death Dis. 2015 Apr 16;6:e1725. doi: 10.1038/cddis.2015.94.

20.

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.

Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L.

J Neurosci. 2015 Feb 11;35(6):2358-71. doi: 10.1523/JNEUROSCI.5791-12.2015.

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