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Protective Effects of Let-7b on the Expression of Occludin by Targeting P38 MAPK in Preventing Intestinal Barrier Dysfunction.

Liu Z, Tian Y, Jiang Y, Chen S, Liu T, Moyer MP, Qin H, Zhou X.

Cell Physiol Biochem. 2018;45(1):343-355. doi: 10.1159/000486815. Epub 2018 Jan 19.


Beta-catenin cleavage enhances transcriptional activation.

Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA.

Sci Rep. 2018 Jan 12;8(1):671. doi: 10.1038/s41598-017-18421-8.


Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.

Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA.

Sci Rep. 2017 Dec 21;7(1):17993. doi: 10.1038/s41598-017-18446-z.


Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.

Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K, Szabo C, Chao C, Hellmich MR.

Cancer Res. 2017 Nov 1;77(21):5741-5754. doi: 10.1158/0008-5472.CAN-16-3480. Epub 2017 Sep 18.


Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs.

Hernández-Morales M, Sobradillo D, Valero RA, Muñoz E, Ubierna D, Moyer MP, Núñez L, Villalobos C.

Oncotarget. 2017 Jul 21;8(33):55332-55352. doi: 10.18632/oncotarget.19430. eCollection 2017 Aug 15.


Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease.

Bradford EM, Ryu SH, Singh AP, Lee G, Goretsky T, Sinh P, Williams DB, Cloud AL, Gounaris E, Patel V, Lamping OF, Lynch EB, Moyer MP, De Plaen IG, Shealy DJ, Yang GY, Barrett TA.

J Immunol. 2017 Sep 1;199(5):1886-1897. doi: 10.4049/jimmunol.1601066. Epub 2017 Jul 26.


Transcriptomic Analysis of Calcium Remodeling in Colorectal Cancer.

Pérez-Riesgo E, Gutiérrez LG, Ubierna D, Acedo A, Moyer MP, Núñez L, Villalobos C.

Int J Mol Sci. 2017 Apr 27;18(5). pii: E922. doi: 10.3390/ijms18050922.


Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.

Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S, Goel A, Qin H, Ma Y.

Gastroenterology. 2017 Mar;152(4):851-866.e24. doi: 10.1053/j.gastro.2016.11.018. Epub 2016 Nov 19.


Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.

Zapletal O, Tylichová Z, Neča J, Kohoutek J, Machala M, Milcová A, Pokorná M, Topinka J, Moyer MP, Hofmanová J, Kozubík A, Vondráček J.

Arch Toxicol. 2017 May;91(5):2135-2150. doi: 10.1007/s00204-016-1887-4. Epub 2016 Nov 9.


Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.

Duncan KW, Rioux N, Boriack-Sjodin PA, Munchhof MJ, Reiter LA, Majer CR, Jin L, Johnston LD, Chan-Penebre E, Kuplast KG, Porter Scott M, Pollock RM, Waters NJ, Smith JJ, Moyer MP, Copeland RA, Chesworth R.

ACS Med Chem Lett. 2015 Dec 2;7(2):162-6. doi: 10.1021/acsmedchemlett.5b00380. eCollection 2016 Feb 11.


N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro.

Beaumatin F, El Dhaybi M, Lasserre JP, Salin B, Moyer MP, Verdier M, Manon S, Priault M.

Oncotarget. 2016 Mar 29;7(13):17129-43. doi: 10.18632/oncotarget.7938.


The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.

Kuntz KW, Campbell JE, Keilhack H, Pollock RM, Knutson SK, Porter-Scott M, Richon VM, Sneeringer CJ, Wigle TJ, Allain CJ, Majer CR, Moyer MP, Copeland RA, Chesworth R.

J Med Chem. 2016 Feb 25;59(4):1556-64. doi: 10.1021/acs.jmedchem.5b01501. Epub 2016 Jan 27.


Corrigendum: Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.

Gonçalves V, Henriques AF, Pereira JF, Costa AN, Moyer MP, Moita LF, Gama-Carvalho M, Matos P, Jordan P.

RNA. 2016 Jan;22(1):166. doi: 10.1261/rna.055020.115. No abstract available.


Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.

Waters NJ, Smith SA, Olhava EJ, Duncan KW, Burton RD, O'Neill J, Rodrigue ME, Pollock RM, Moyer MP, Chesworth R.

Cancer Chemother Pharmacol. 2016 Jan;77(1):43-62. doi: 10.1007/s00280-015-2929-y. Epub 2015 Dec 8.


Gastrointestinal digested Sambucus nigra L. fruit extract protects in vitro cultured human colon cells against oxidative stress.

Olejnik A, Olkowicz M, Kowalska K, Rychlik J, Dembczyński R, Myszka K, Juzwa W, Białas W, Moyer MP.

Food Chem. 2016 Apr 15;197(Pt A):648-57. doi: 10.1016/j.foodchem.2015.11.017. Epub 2015 Nov 10.


A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.

Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA.

J Biol Chem. 2016 Feb 19;291(8):4166-77. doi: 10.1074/jbc.M115.669416. Epub 2015 Nov 12.


Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.

Boriack-Sjodin PA, Jin L, Jacques SL, Drew A, Sneeringer C, Scott MP, Moyer MP, Ribich S, Moradei O, Copeland RA.

ACS Chem Biol. 2016 Mar 18;11(3):763-71. doi: 10.1021/acschembio.5b00773. Epub 2015 Nov 23.


Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells.

Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer MP, Ehrmann J, Hyršlová Vaculová A.

PLoS One. 2015 Oct 22;10(10):e0141020. doi: 10.1371/journal.pone.0141020. eCollection 2015.


Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A.

Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021.


Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells.

Henriques AF, Barros P, Moyer MP, Matos P, Jordan P.

Cancer Lett. 2015 Dec 28;369(2):368-75. doi: 10.1016/j.canlet.2015.08.027. Epub 2015 Sep 1.


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