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Items: 8


Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells.

Moulton VR, Gillooly AR, Perl MA, Markopoulou A, Tsokos GC.

PLoS One. 2015 Jul 2;10(7):e0131073. doi: 10.1371/journal.pone.0131073. eCollection 2015.


T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.

Moulton VR, Tsokos GC.

J Clin Invest. 2015 Jun;125(6):2220-7. doi: 10.1172/JCI78087. Epub 2015 May 11. Review.


Ubiquitination regulates expression of the serine/arginine-rich splicing factor 1 (SRSF1) in normal and systemic lupus erythematosus (SLE) T cells.

Moulton VR, Gillooly AR, Tsokos GC.

J Biol Chem. 2014 Feb 14;289(7):4126-34. doi: 10.1074/jbc.M113.518662. Epub 2013 Dec 24.


Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription.

Moulton VR, Grammatikos AP, Fitzgerald LM, Tsokos GC.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1845-50. doi: 10.1073/pnas.1214207110. Epub 2013 Jan 14.


Estrogen upregulates cyclic AMP response element modulator α expression and downregulates interleukin-2 production by human T lymphocytes.

Moulton VR, Holcomb DR, Zajdel MC, Tsokos GC.

Mol Med. 2012 May 9;18:370-8. doi: 10.2119/molmed.2011.00506.


Abnormalities of T cell signaling in systemic lupus erythematosus.

Moulton VR, Tsokos GC.

Arthritis Res Ther. 2011 Mar 17;13(2):207. doi: 10.1186/ar3251. Review.


Alternative splicing factor/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex.

Moulton VR, Tsokos GC.

J Biol Chem. 2010 Apr 23;285(17):12490-6. doi: 10.1074/jbc.M109.091660. Epub 2010 Jan 29.


The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex.

Moulton VR, Kyttaris VC, Juang YT, Chowdhury B, Tsokos GC.

J Biol Chem. 2008 Jul 18;283(29):20037-44. doi: 10.1074/jbc.M710434200. Epub 2008 May 27.

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