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Items: 1 to 20 of 92

1.

Role of Sirtuins in Retinal Function Under Basal Conditions.

Lin JB, Kubota S, Mostoslavsky R, Apte RS.

Adv Exp Med Biol. 2018;1074:561-567. doi: 10.1007/978-3-319-75402-4_68.

PMID:
29721988
2.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R.

Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19.

PMID:
29555651
3.

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.

Santos-Barriopedro I, Bosch-Presegué L, Marazuela-Duque A, de la Torre C, Colomer C, Vazquez BN, Fuhrmann T, Martínez-Pastor B, Lu W, Braun T, Bober E, Jenuwein T, Serrano L, Esteller M, Chen Z, Barceló-Batllori S, Mostoslavsky R, Espinosa L, Vaquero A.

Nat Commun. 2018 Jan 9;9(1):101. doi: 10.1038/s41467-017-02586-x.

4.

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.

Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM.

J Neurochem. 2018 Jan;144(2):128-138. doi: 10.1111/jnc.14243. Epub 2017 Nov 21.

PMID:
29049850
5.

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM.

Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3.

PMID:
28974511
6.

Reprogramming Enhancers to Drive Metastasis.

Mostoslavsky R, Bardeesy N.

Cell. 2017 Aug 24;170(5):823-825. doi: 10.1016/j.cell.2017.08.010.

PMID:
28841414
7.

Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair.

Linder SJ, Mostoslavsky R.

Mol Cell. 2017 Jul 20;67(2):165-167. doi: 10.1016/j.molcel.2017.07.006.

PMID:
28732204
8.

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.

Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S.

FASEB J. 2017 Jul;31(7):3138-3149. doi: 10.1096/fj.201601294R. Epub 2017 Apr 6.

PMID:
28386046
9.

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K.

Cell Stem Cell. 2017 May 4;20(5):706-719.e7. doi: 10.1016/j.stem.2017.03.002. Epub 2017 Mar 30.

10.

Neuroprotective Functions for the Histone Deacetylase SIRT6.

Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D.

Cell Rep. 2017 Mar 28;18(13):3052-3062. doi: 10.1016/j.celrep.2017.03.008.

11.

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.

Ioris RM, Galié M, Ramadori G, Anderson JG, Charollais A, Konstantinidou G, Brenachot X, Aras E, Goga A, Ceglia N, Sebastián C, Martinvalet D, Mostoslavsky R, Baldi P, Coppari R.

Cell Rep. 2017 Feb 21;18(8):1858-1868. doi: 10.1016/j.celrep.2017.01.065.

12.

The Various Metabolic Sources of Histone Acetylation.

Sebastián C, Mostoslavsky R.

Trends Endocrinol Metab. 2017 Feb;28(2):85-87. doi: 10.1016/j.tem.2016.11.001. Epub 2016 Nov 16.

PMID:
27863854
13.

Sox2 Suppresses Gastric Tumorigenesis in Mice.

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K.

Cell Rep. 2016 Aug 16;16(7):1929-41. doi: 10.1016/j.celrep.2016.07.034. Epub 2016 Aug 4.

14.

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

Etchegaray JP, Mostoslavsky R.

Mol Cell. 2016 Jun 2;62(5):695-711. doi: 10.1016/j.molcel.2016.05.029. Review.

15.

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R.

Cell. 2016 Jun 2;165(6):1401-1415. doi: 10.1016/j.cell.2016.04.033. Epub 2016 May 12.

16.

SIRT6: a new guardian of mitosis.

Pastor BM, Mostoslavsky R.

Nat Struct Mol Biol. 2016 May 4;23(5):360-2. doi: 10.1038/nsmb.3222. No abstract available.

PMID:
27142319
17.

Sirt6 regulates dendritic cell differentiation, maturation, and function.

Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A.

Aging (Albany NY). 2016 Jan;8(1):34-49.

18.

Cancer and metabolism: Why should we care?

Gottlieb E, Mostoslavsky R.

Semin Cell Dev Biol. 2015 Jul;43:1-2. doi: 10.1016/j.semcdb.2015.10.007. No abstract available.

PMID:
26611348
19.

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R.

Cell Rep. 2015 Oct 20;13(3):479-488. doi: 10.1016/j.celrep.2015.09.022. Epub 2015 Oct 8.

20.

The role of mammalian sirtuins in cancer metabolism.

Sebastián C, Mostoslavsky R.

Semin Cell Dev Biol. 2015 Jul;43:33-42. doi: 10.1016/j.semcdb.2015.07.008. Epub 2015 Jul 31. Review.

PMID:
26238985

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