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Items: 1 to 20 of 61

1.

Mapping the energy landscapes of supramolecular assembly by thermal hysteresis.

Harkness V RW, Avakyan N, Sleiman HF, Mittermaier AK.

Nat Commun. 2018 Aug 8;9(1):3152. doi: 10.1038/s41467-018-05502-z.

2.

Complete Kinetic Characterization of Enzyme Inhibition in a Single Isothermal Titration Calorimetric Experiment.

Di Trani JM, Moitessier N, Mittermaier AK.

Anal Chem. 2018 Jul 17;90(14):8430-8435. doi: 10.1021/acs.analchem.8b00993. Epub 2018 Jul 6.

PMID:
29926719
3.

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM.

Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412.

PMID:
29603451
4.

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry.

Di Trani JM, De Cesco S, O'Leary R, Plescia J, do Nascimento CJ, Moitessier N, Mittermaier AK.

Nat Commun. 2018 Mar 1;9(1):893. doi: 10.1038/s41467-018-03263-3.

5.

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions.

Harkness V RW, Johnson PE, Mittermaier AK.

J Vis Exp. 2017 Nov 21;(129). doi: 10.3791/55959.

PMID:
29286441
6.

Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of γ-tubulin induced by mutation of a conserved tyrosine residue.

Harris J, Shadrina M, Oliver C, Vogel J, Mittermaier A.

Protein Sci. 2018 Feb;27(2):531-545. doi: 10.1002/pro.3345. Epub 2017 Dec 15.

PMID:
29127738
7.

Efficient and Rapid Mechanochemical Assembly of Platinum(II) Squares for Guanine Quadruplex Targeting.

Garci A, Castor KJ, Fakhoury J, Do JL, Di Trani J, Chidchob P, Stein RS, Mittermaier AK, Friščić T, Sleiman H.

J Am Chem Soc. 2017 Nov 22;139(46):16913-16922. doi: 10.1021/jacs.7b09819. Epub 2017 Nov 14.

PMID:
29058892
8.

Covalent inhibitors design and discovery.

De Cesco S, Kurian J, Dufresne C, Mittermaier AK, Moitessier N.

Eur J Med Chem. 2017 Sep 29;138:96-114. doi: 10.1016/j.ejmech.2017.06.019. Epub 2017 Jun 10. Review.

PMID:
28651155
9.

G-quadruplex dynamics.

Harkness RW 5th, Mittermaier AK.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1544-1554. doi: 10.1016/j.bbapap.2017.06.012. Epub 2017 Jun 20. Review.

PMID:
28642152
10.

Measuring Rapid Time-Scale Reaction Kinetics Using Isothermal Titration Calorimetry.

Di Trani JM, Moitessier N, Mittermaier AK.

Anal Chem. 2017 Jul 5;89(13):7022-7030. doi: 10.1021/acs.analchem.7b00693. Epub 2017 Jun 21.

PMID:
28590118
11.

Rapid characterization of folding and binding interactions with thermolabile ligands by DSC.

Harkness RW, Slavkovic S, Johnson PE, Mittermaier AK.

Chem Commun (Camb). 2016 Nov 10;52(92):13471-13474.

PMID:
27790660
12.

Stabilization of i-motif structures by 2'-β-fluorination of DNA.

Assi HA, Harkness RW 5th, Martin-Pintado N, Wilds CJ, Campos-Olivas R, Mittermaier AK, González C, Damha MJ.

Nucleic Acids Res. 2016 Jun 20;44(11):4998-5009. doi: 10.1093/nar/gkw402. Epub 2016 May 10.

13.

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.

El-Turk F, Newby FN, De Genst E, Guilliams T, Sprules T, Mittermaier A, Dobson CM, Vendruscolo M.

Biochemistry. 2016 Jun 7;55(22):3116-22. doi: 10.1021/acs.biochem.6b00149. Epub 2016 May 26.

PMID:
27096466
14.

G-register exchange dynamics in guanine quadruplexes.

Harkness RW 5th, Mittermaier AK.

Nucleic Acids Res. 2016 May 5;44(8):3481-94. doi: 10.1093/nar/gkw190. Epub 2016 Apr 7.

15.

3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.

Mariaule G, De Cesco S, Airaghi F, Kurian J, Schiavini P, Rocheleau S, Huskić I, Auclair K, Mittermaier A, Moitessier N.

J Med Chem. 2016 May 12;59(9):4221-34. doi: 10.1021/acs.jmedchem.5b01296. Epub 2015 Dec 14.

PMID:
26619267
16.

Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.

Chong PA, Farber PJ, Vernon RM, Hudson RP, Mittermaier AK, Forman-Kay JD.

J Biol Chem. 2015 Sep 18;290(38):22862-78. doi: 10.1074/jbc.M115.641134. Epub 2015 Jul 6.

17.

Relaxation dispersion NMR spectroscopy for the study of protein allostery.

Farber PJ, Mittermaier A.

Biophys Rev. 2015 Jun;7(2):191-200. doi: 10.1007/s12551-015-0166-6. Epub 2015 Feb 21. Review.

18.

Conformational plasticity surrounding the active site of NADH oxidase from Thermus thermophilus.

Miletti T, Di Trani J, Levros LC Jr, Mittermaier A.

Protein Sci. 2015 Jul;24(7):1114-28. doi: 10.1002/pro.2693. Epub 2015 May 29.

19.

An enzyme cofactor with a split personality.

Mittermaier A.

Nat Struct Mol Biol. 2015 Feb;22(2):101-3. doi: 10.1038/nsmb.2968. No abstract available.

PMID:
25650903
20.

Global ITC fitting methods in studies of protein allostery.

Freiburger L, Auclair K, Mittermaier A.

Methods. 2015 Apr;76:149-161. doi: 10.1016/j.ymeth.2014.12.018. Epub 2015 Jan 5. Review.

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