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Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.

Chen Y, Litvintseva AP, Frazzitta AE, Haverkamp MR, Wang L, Fang C, Muthoga C, Mitchell TG, Perfect JR.

Mol Ecol. 2015 Jul;24(14):3559-71. doi: 10.1111/mec.13260.


Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing.

Chen Y, Frazzitta AE, Litvintseva AP, Fang C, Mitchell TG, Springer DJ, Ding Y, Yuan G, Perfect JR.

Fungal Genet Biol. 2015 Feb;75:64-71. doi: 10.1016/j.fgb.2015.01.005.


Multilocus sequence typing of serially collected isolates of Cryptococcus from HIV-infected patients in South Africa.

Van Wyk M, Govender NP, Mitchell TG, Litvintseva AP; GERMS-SA..

J Clin Microbiol. 2014 Jun;52(6):1921-31. doi: 10.1128/JCM.03177-13.


The Cryptococcus neoformans transcriptome at the site of human meningitis.

Chen Y, Toffaletti DL, Tenor JL, Litvintseva AP, Fang C, Mitchell TG, McDonald TR, Nielsen K, Boulware DR, Bicanic T, Perfect JR.

MBio. 2014 Feb 4;5(1):e01087-13. doi: 10.1128/mBio.01087-13.


Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii.

Litvintseva AP, Mitchell TG.

PLoS Pathog. 2012 Feb;8(2):e1002495. doi: 10.1371/journal.ppat.1002495. No abstract available.


Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.

Schell WA, Benton JL, Smith PB, Poore M, Rouse JL, Boles DJ, Johnson MD, Alexander BD, Pamula VK, Eckhardt AE, Pollack MG, Benjamin DK Jr, Perfect JR, Mitchell TG.

Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2237-45. doi: 10.1007/s10096-012-1561-6.


Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

Hu G, Wang J, Choi J, Jung WH, Liu I, Litvintseva AP, Bicanic T, Aurora R, Mitchell TG, Perfect JR, Kronstad JW.

BMC Genomics. 2011 Oct 27;12:526. doi: 10.1186/1471-2164-12-526.


Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa.

Litvintseva AP, Carbone I, Rossouw J, Thakur R, Govender NP, Mitchell TG.

PLoS One. 2011 May 11;6(5):e19688. doi: 10.1371/journal.pone.0019688.


Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.

Miglia KJ, Govender NP, Rossouw J, Meiring S, Mitchell TG; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa..

J Clin Microbiol. 2011 Jan;49(1):307-14. doi: 10.1128/JCM.01277-10.


Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.

Wulff-Burchfield E, Schell WA, Eckhardt AE, Pollack MG, Hua Z, Rouse JL, Pamula VK, Srinivasan V, Benton JL, Alexander BD, Wilfret DA, Kraft M, Cairns CB, Perfect JR, Mitchell TG.

Diagn Microbiol Infect Dis. 2010 May;67(1):22-9. doi: 10.1016/j.diagmicrobio.2009.12.020.


Multiplexed real-time polymerase chain reaction on a digital microfluidic platform.

Hua Z, Rouse JL, Eckhardt AE, Srinivasan V, Pamula VK, Schell WA, Benton JL, Mitchell TG, Pollack MG.

Anal Chem. 2010 Mar 15;82(6):2310-6. doi: 10.1021/ac902510u.


Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties.

Ngamskulrungroj P, Gilgado F, Faganello J, Litvintseva AP, Leal AL, Tsui KM, Mitchell TG, Vainstein MH, Meyer W.

PLoS One. 2009 Jun 10;4(6):e5862. doi: 10.1371/journal.pone.0005862. Erratum in: PLoS One. 2009;4(7). doi: 10.1371/annotation/348c3375-3918-4e41-bb8c-27aa15d2bdc4. PLoS One. 2009;4(7). doi: 10.1371/annotation/3037bb69-1b8e-4d99-b169-afdf4b74ace2.


Most environmental isolates of Cryptococcus neoformans var. grubii (serotype A) are not lethal for mice.

Litvintseva AP, Mitchell TG.

Infect Immun. 2009 Aug;77(8):3188-95. doi: 10.1128/IAI.00296-09.


Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii.

Meyer W, Aanensen DM, Boekhout T, Cogliati M, Diaz MR, Esposto MC, Fisher M, Gilgado F, Hagen F, Kaocharoen S, Litvintseva AP, Mitchell TG, Simwami SP, Trilles L, Viviani MA, Kwon-Chung J.

Med Mycol. 2009;47(6):561-70. doi: 10.1080/13693780902953886. Review.


Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.

Byrnes EJ 3rd, Bildfell RJ, Frank SA, Mitchell TG, Marr KA, Heitman J.

J Infect Dis. 2009 Apr 1;199(7):1081-6. doi: 10.1086/597306.


Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating.

Lin X, Patel S, Litvintseva AP, Floyd A, Mitchell TG, Heitman J.

PLoS Pathog. 2009 Jan;5(1):e1000283. doi: 10.1371/journal.ppat.1000283.


alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness.

Lin X, Litvintseva AP, Nielsen K, Patel S, Floyd A, Mitchell TG, Heitman J.

PLoS Genet. 2007 Oct;3(10):1975-90.


Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa.

Litvintseva AP, Lin X, Templeton I, Heitman J, Mitchell TG.

PLoS Pathog. 2007 Aug 17;3(8):e114.


Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India.

Gugnani HC, Mitchell TG, Litvintseva AP, Lengeler KB, Heitman J, Kumar A, Basu S, Paliwal-Joshi A.

Med Mycol. 2005 Sep;43(6):565-9.

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