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Items: 1 to 20 of 39

1.

Metabolic hijacking: A survival strategy cancer cells exploit?

Mitchell MI, Engelbrecht AM.

Crit Rev Oncol Hematol. 2017 Jan;109:1-8. doi: 10.1016/j.critrevonc.2016.11.010. Epub 2016 Nov 21. Review.

PMID:
28010894
2.

Relative bioavailability of three formulations of galunisertib administered as monotherapy in patients with advanced or metastatic cancer.

Gueorguieva I, Cleverly A, Desaiah D, Azaro A, Seoane J, Braña I, Sicart E, Miles C, Lahn MM, Mitchell MI, Rodon J.

Drugs Context. 2016 Dec 2;5:212303. eCollection 2016.

3.

In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1.

Pak YA, Long AJ, Annes WF, Witcher JW, Knadler MP, Ayan-Oshodi MA, Mitchell MI, Leese P, Hillgren KM.

Drug Metab Dispos. 2017 Feb;45(2):137-144. doi: 10.1124/dmd.116.071118. Epub 2016 Nov 28.

4.

Evaluation of the effect of necitumumab on the corrected QT interval in patients with advanced solid tumors.

Smith DC, Powderly J, Lee JJ, Shepard DR, Wallin J, Chaudhary A, Chao GY, Ng WT, Mitchell MI, Grau G, Kurek R, LoRusso P.

Cancer Chemother Pharmacol. 2016 Aug;78(2):271-80. doi: 10.1007/s00280-016-3074-y. Epub 2016 Jun 16.

PMID:
27312733
5.

Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solution by Healthy Male Volunteers.

Satonin DK, Ni X, Mitchell MI, Joly H, Muram D, Small DS.

J Sex Med. 2016 Feb;13(2):187-93. doi: 10.1016/j.jsxm.2015.12.007. Epub 2016 Jan 20.

PMID:
26803453
6.

Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death.

Mitchell MI, Engelbrecht AM.

J Toxicol. 2015;2015:392360. doi: 10.1155/2015/392360. Epub 2015 Aug 11.

7.

Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.

Heller S, Darpö B, Mitchell MI, Linnebjerg H, Leishman DJ, Mehrotra N, Zhu H, Koerner J, Fiszman ML, Balakrishnan S, Xiao S, Todaro TG, Hensley I, Guth BD, Michelson EL, Sager P.

Am Heart J. 2015 Jul;170(1):23-35. doi: 10.1016/j.ahj.2015.03.007. Epub 2015 Mar 18. Review.

PMID:
26093861
8.

Effect of pomaglumetad methionil on the QT interval in subjects with schizophrenia.

Zhang W, Mitchell MI, Knadler MP, Long A, Witcher J, Walling D, Annes W, Ayan-Oshodi M.

Int J Clin Pharmacol Ther. 2015 Jun;53(6):462-70. doi: 10.5414/CP202289.

PMID:
25881753
9.

Relative contributions of presystemic and systemic peptidases to oral exposure of a novel metabotropic glutamate 2/3 receptor agonist (LY404039) after oral administration of prodrug pomaglumetad methionil (LY2140023).

Annes WF, Long A, Witcher JW, Ayan-Oshodi MA, Knadler MP, Zhang W, Mitchell MI, Cornelissen K, Hall SD.

J Pharm Sci. 2015 Jan;104(1):207-14. doi: 10.1002/jps.24226. Epub 2014 Nov 7.

PMID:
25382826
10.

Effect of deodorant and antiperspirant use and presence or absence of axillary hair on absorption of testosterone 2% solution applied to men's axillae.

Small DS, Ni X, Polzer P, Vart R, Satonin DK, Mitchell MI.

J Sex Med. 2014 Nov;11(11):2809-17. doi: 10.1111/jsm.12658. Epub 2014 Aug 14.

PMID:
25123988
11.

Modeling and simulations to confirm a controlled hypoglycemic stress test in healthy subjects is not associated with clinically significant QT prolongations.

Tham LS, Fen Zhao CM, Natanegara F, Lowe S, Chen C, Lim CN, Linnebjerg H, Willis BA, Mitchell MI, Wise SD.

Int J Clin Pharmacol Ther. 2014 Sep;52(9):717-25. doi: 10.5414/CP202012.

PMID:
24887333
12.

Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors.

Wickremsinhe ER, Hynes SM, Palmieri MD, Mitchell MI, Abraham TL, Rehmel JF, Chana E, Jost LM, Cassidy KC.

Xenobiotica. 2014 Sep;44(9):827-41. doi: 10.3109/00498254.2014.900589. Epub 2014 Mar 26.

PMID:
24666335
13.

Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects.

Chappell JC, Eisenhofer G, Owens MJ, Haber H, Lachno DR, Dean RA, Knadler MP, Nemeroff CB, Mitchell MI, Detke MJ, Iyengar S, Pangallo B, Lobo ED.

J Clin Psychopharmacol. 2014 Feb;34(1):9-16. doi: 10.1097/JCP.0000000000000061.

PMID:
24346757
14.

The effect of hepatic or renal impairment on the pharmacokinetics of edivoxetine, a selective norepinephrine transporter reuptake inhibitor.

Kielbasa W, Tesfaye E, Luffer-Atlas D, Mitchell MI, Turik MA.

Eur J Clin Pharmacol. 2013 Dec;69(12):2011-9. doi: 10.1007/s00228-013-1572-y. Epub 2013 Aug 17.

15.

Evaluation of the effects of duloxetine and escitalopram on 24-hour heart rate variability: a mechanistic study using heart rate variability as a pharmacodynamic measure.

Chappell JC, Kovacs R, Haber H, Wright R, Mitchell MI, Detke M, Pangallo B.

J Clin Psychopharmacol. 2013 Apr;33(2):236-9. doi: 10.1097/JCP.0b013e31828567b6.

PMID:
23422380
16.

Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers.

Loghin C, Haber H, Beasley CM Jr, Kothare PA, Kauffman L, April J, Jin L, Allen AJ, Mitchell MI.

Br J Clin Pharmacol. 2013 Feb;75(2):538-49. doi: 10.1111/j.1365-2125.2012.04382.x.

17.

Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial.

Kothare PA, Seger ME, Northrup J, Mace K, Mitchell MI, Linnebjerg H.

BMC Clin Pharmacol. 2012 Mar 19;12:8. doi: 10.1186/1472-6904-12-8.

18.

A thorough QT study to evaluate the effects of singledose exenatide 10 μg on cardiac repolarization in healthy subjects.

Linnebjerg H, Seger M, Kothare PA, Hunt T, Wolka AM, Mitchell MI.

Int J Clin Pharmacol Ther. 2011 Oct;49(10):594-604.

PMID:
21961484
19.

Evaluation of methods for achieving stable INR in healthy subjects during a multiple-dose warfarin study.

Chappell JC, Dickinson G, Mitchell MI, Haber H, Jin Y, Lobo ED.

Eur J Clin Pharmacol. 2012 Mar;68(3):239-47. doi: 10.1007/s00228-011-1114-4. Epub 2011 Sep 1.

PMID:
21881887
20.

Systematic decrements in QTc between the first and second day of contiguous daily ECG recordings under controlled conditions.

Beasley CM Jr, Benson C, Xia JQ, Young SS, Haber H, Mitchell MI, Loghin C.

Pacing Clin Electrophysiol. 2011 Sep;34(9):1116-27. doi: 10.1111/j.1540-8159.2011.03117.x. Epub 2011 Apr 28.

PMID:
21535038

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