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Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C.

Blood. 2018 Mar 2. pii: blood-2017-11-814681. doi: 10.1182/blood-2017-11-814681. [Epub ahead of print]


Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C.

J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.


Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.

Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V.

Biochim Biophys Acta. 2018 Feb;1863(2):199-211. doi: 10.1016/j.bbalip.2017.11.009. Epub 2017 Dec 2.


Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J.

Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12.


New Insights in the Pathophysiology of Antiphospholipid Syndrome.

Sacharidou A, Shaul PW, Mineo C.

Semin Thromb Hemost. 2017 Jan 27. doi: 10.1055/s-0036-1597286. [Epub ahead of print]


Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW.

Endocrinology. 2016 Oct;157(10):3731-3741. Epub 2016 Aug 23.


Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW.

PLoS One. 2016 Jul 27;11(7):e0158757. doi: 10.1371/journal.pone.0158757. eCollection 2016.


Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C.

Diabetes. 2016 Jul;65(7):1996-2005. doi: 10.2337/db15-1605. Epub 2016 Apr 26.


Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.

Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J.

Sci Signal. 2016 Mar 15;9(419):ra29. doi: 10.1126/scisignal.aad5578.


Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.

Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, Cleaver O.

Angiogenesis. 2016 Apr;19(2):173-90. doi: 10.1007/s10456-016-9498-5. Epub 2016 Feb 20.


ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.

Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C.

Arthritis Rheumatol. 2016 Mar;68(3):730-739. doi: 10.1002/art.39453.


PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C.

PLoS One. 2015 Apr 17;10(4):e0124494. doi: 10.1371/journal.pone.0124494. eCollection 2015.


Fcγ receptors and ligands and cardiovascular disease.

Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW.

Circ Res. 2015 Jan 16;116(2):368-84. doi: 10.1161/CIRCRESAHA.116.302795. Review.


IgG receptor FcγRIIB plays a key role in obesity-induced hypertension.

Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW.

Hypertension. 2015 Feb;65(2):456-62. doi: 10.1161/HYPERTENSIONAHA.114.04670. Epub 2014 Nov 3.


Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.

Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C.

J Am Heart Assoc. 2014 Oct 14;3(5):e001369. doi: 10.1161/JAHA.114.001369.


Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.

Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13493-8. doi: 10.1073/pnas.1402106111. Epub 2014 Sep 2.


The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.

Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW.

Cell Metab. 2014 Jul 1;20(1):172-82. doi: 10.1016/j.cmet.2014.05.013. Epub 2014 Jun 19.


Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.

Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17.


Recent insights into non-nuclear actions of estrogen receptor alpha.

Banerjee S, Chambliss KL, Mineo C, Shaul PW.

Steroids. 2014 Mar;81:64-9. doi: 10.1016/j.steroids.2013.11.002. Epub 2013 Nov 16. Review.


27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.

Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW.

Cell Rep. 2013 Nov 14;5(3):637-45. doi: 10.1016/j.celrep.2013.10.006. Epub 2013 Nov 7.

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