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Items: 1 to 20 of 43


Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin.

Gaidos G, Panaitiu AE, Guo B, Pellegrini M, Mierke DF.

PLoS One. 2015 Nov 3;10(11):e0141692. doi: 10.1371/journal.pone.0141692. eCollection 2015.


Assembly and turnover of short actin filaments by the formin INF2 and profilin.

Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN.

J Biol Chem. 2015 Sep 11;290(37):22494-506. doi: 10.1074/jbc.M115.670166. Epub 2015 Jun 29.


A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.

Bucur O, Gaidos G, Yatawara A, Pennarun B, Rupasinghe C, Roux J, Andrei S, Guo B, Panaitiu A, Pellegrini M, Mierke DF, Khosravi-Far R.

Sci Rep. 2015 May 11;5:9893. doi: 10.1038/srep09893.


Modulating the dysregulated migration of pulmonary arterial hypertensive smooth muscle cells with motif mimicking cell permeable peptides.

Wilson JL, Rupasinghe C, Usheva A, Warburton R, Kaplan C, Taylor L, Hill N, Mierke DF, Polgar P.

Curr Top Pept Protein Res. 2015;16:1-17.


Small-molecule inhibitors of JC polyomavirus infection.

Yatawara A, Gaidos G, Rupasinghe CN, O'Hara BA, Pellegrini M, Atwood WJ, Mierke DF.

J Pept Sci. 2015 Mar;21(3):236-42. doi: 10.1002/psc.2731. Epub 2014 Dec 19.


Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).

Song GJ, Leslie KL, Barrick S, Mamonova T, Fitzpatrick JM, Drombosky KW, Peyser N, Wang B, Pellegrini M, Bauer PM, Friedman PA, Mierke DF, Bisello A.

J Biol Chem. 2015 Jan 30;290(5):2879-87. doi: 10.1074/jbc.M114.609768. Epub 2014 Dec 9.


Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathway.

Zheng F, Jewell H, Fitzpatrick J, Zhang J, Mierke DF, Grigoryan G.

J Mol Biol. 2015 Jan 30;427(2):491-510. doi: 10.1016/j.jmb.2014.10.014. Epub 2014 Oct 30.


Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.

Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P.

Chem Biol Drug Des. 2015 May;85(5):586-97. doi: 10.1111/cbdd.12446. Epub 2014 Nov 5.


Protein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKK╬▓ binding.

Guo B, Audu CO, Cochran JC, Mierke DF, Pellegrini M.

Biochemistry. 2014 Nov 4;53(43):6776-85. doi: 10.1021/bi500861x. Epub 2014 Oct 23.


Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction.

Fitzpatrick JM, Pellegrini M, Cushing PR, Mierke DF.

Biochemistry. 2014 Sep 23;53(37):5916-22. doi: 10.1021/bi500368k. Epub 2014 Sep 15.


Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.

Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF.

Chem Commun (Camb). 2014 Oct 18;50(81):12037-9. doi: 10.1039/c4cc04399e.


Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection.

O'Hara BA, Rupasinghe C, Yatawara A, Gaidos G, Mierke DF, Atwood WJ.

Virus Res. 2014 Aug 30;189:280-5. doi: 10.1016/j.virusres.2014.06.008. Epub 2014 Jun 21.


A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model.

Green DS, Rupasinghe C, Warburton R, Wilson JL, Sallum CO, Taylor L, Yatawara A, Mierke D, Polgar P, Hill N.

PLoS One. 2013 Nov 27;8(11):e81309. doi: 10.1371/journal.pone.0081309. eCollection 2013.


killerFLIP: a novel lytic peptide specifically inducing cancer cell death.

Pennarun B, Gaidos G, Bucur O, Tinari A, Rupasinghe C, Jin T, Dewar R, Song K, Santos MT, Malorni W, Mierke D, Khosravi-Far R.

Cell Death Dis. 2013 Oct 31;4:e894. doi: 10.1038/cddis.2013.401.


Recombinant production of TEV cleaved human parathyroid hormone.

Audu CO, Cochran JC, Pellegrini M, Mierke DF.

J Pept Sci. 2013 Aug;19(8):504-10. doi: 10.1002/psc.2528. Epub 2013 Jun 23.


AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1).

Fellows A, Mierke DF, Nichols RC.

Cytokine. 2013 Oct;64(1):337-42. doi: 10.1016/j.cyto.2013.05.019. Epub 2013 Jun 14.


Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression.

Fellows A, Deng B, Mierke DF, Robey RB, Nichols RC.

Int Immunopharmacol. 2013 Sep;17(1):132-41. doi: 10.1016/j.intimp.2013.05.014. Epub 2013 Jun 5.


C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission.

Yatawara A, Wilson JL, Taylor L, Polgar P, Mierke DF.

J Pept Sci. 2013 Apr;19(4):257-62. doi: 10.1002/psc.2499. Epub 2013 Feb 25.


Ligand binding site identification by higher dimension molecular dynamics.

Yatawara AK, Hodoscek M, Mierke DF.

J Chem Inf Model. 2013 Mar 25;53(3):674-80. doi: 10.1021/ci300561b. Epub 2013 Feb 20.


Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding.

Audu CO, O'Hara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF.

Biochemistry. 2012 Oct 16;51(41):8092-9. doi: 10.1021/bi300639d. Epub 2012 Oct 2.

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