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Intern Med J. 2011 Sep;41(9):695-9. doi: 10.1111/j.1445-5994.2011.02545.x.

Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: the role of parafibromin in increasing diagnostic accuracy.

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Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand.


Parathyroid carcinoma, although a rare cause of primary hyperparathyroidism, carries a significant morbidity and mortality from severe symptomatic hypercalcaemia and related complications. We report a case where the diagnosis was not considered from the outset and review the current clinical and histopathological markers available to assist in the diagnosis of parathyroid carcinoma.

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