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Items: 1 to 20 of 15078

1.

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus.

Vázquez R, Riveiro ME, Astorgues-Xerri L, Odore E, Rezai K, Erba E, Panini N, Rinaldi A, Kwee I, Beltrame L, Bekradda M, Cvitkovic E, Bertoni F, Frapolli R, D'Incalci M.

Oncotarget. 2016 Dec 7. doi: 10.18632/oncotarget.13814. [Epub ahead of print]

PMID:
27935867
2.

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D.

Elife. 2016 Dec 9;5. pii: e20722. doi: 10.7554/eLife.20722. [Epub ahead of print]

PMID:
27935476
3.

Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phospho-Ethanolamine in Patients with Solid Tumors.

Scheible H, Kraetzer F, Marx A, Johne A, Wimmer E.

Drug Metab Dispos. 2016 Dec 1. pii: dmd.116.072934. [Epub ahead of print]

PMID:
27934635
4.

Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.

Chan ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Saurí J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR.

J Org Chem. 2016 Nov 18;81(22):10631-10640.

PMID:
27934476
5.

A General, One-Pot Method for the Synthesis of Sulfinic Acids from Methyl Sulfones.

Gauthier DR Jr, Yoshikawa N.

Org Lett. 2016 Dec 2;18(23):5994-5997.

PMID:
27934354
6.

In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model.

Soon RL, Lenhard JR, Bulman ZP, Holden PN, Kelchlin P, Steenbergen JN, Friedrich LV, Forrest A, Tsuji BT.

Int J Antimicrob Agents. 2016 Sep 1. pii: S0924-8579(16)30224-2. doi: 10.1016/j.ijantimicag.2016.07.015. [Epub ahead of print]

PMID:
27931793
7.

Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice.

Thoryk EA, Swaminathan G, Meschino S, Cox KS, Gindy M, Casimiro DR, Bett AJ.

Vaccines (Basel). 2016 Dec 6;4(4). pii: E47.

PMID:
27929422
8.

Genetic Variants Associated with Circulating Parathyroid Hormone.

Robinson-Cohen C, Lutsey PL, Kleber ME, Nielson CM, Mitchell BD, Bis JC, Eny KM, Portas L, Eriksson J, Lorentzon M, Koller DL, Milaneschi Y, Teumer A, Pilz S, Nethander M, Selvin E, Tang W, Weng LC, Wong HS, Lai D, Peacock M, Hannemann A, Völker U, Homuth G, Nauk M, Murgia F, Pattee JW, Orwoll E, Zmuda JM, Riancho JA, Wolf M, Williams F, Penninx B, Econs MJ, Ryan KA, Ohlsson C, Paterson AD, Psaty BM, Siscovick DS, Rotter JI, Pirastu M, Streeten E, März W, Fox C, Coresh J, Wallaschofski H, Pankow JS, de Boer IH, Kestenbaum B.

J Am Soc Nephrol. 2016 Dec 7. pii: ASN.2016010069. [Epub ahead of print]

PMID:
27927781
9.

Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants.

Bialas KM, Westreich D, Cisneros de la Rosa E, Nelson CS, Kauvar LM, Fu TM, Permar SR.

J Infect Dis. 2016 Dec 15;214(12):1916-1923.

PMID:
27923951
10.

The importance of vial composition in HPLC analysis: An unusual case of phosphorous pseudorotation.

Arvary R, Mangion I.

J Pharm Biomed Anal. 2016 Oct 6;134:237-242. doi: 10.1016/j.jpba.2016.10.004. [Epub ahead of print]

PMID:
27923199
11.

Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats.

Zhou X, Forrest MJ, Sharif-Rodriguez W, Forrest G, Szeto D, Urosevic-Price O, Zhu Y, Stevenson AS, Zhou Y, Stribling S, Dajee M, Walsh SP, Pasternak A, Sullivan KA.

Hypertension. 2016 Dec 5. pii: HYPERTENSIONAHA.116.08358. [Epub ahead of print]

PMID:
27920129
12.

On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT).

Blazing MA, Giugliano RP, de Lemos JA, Cannon CP, Tonkin A, Ballantyne CM, Lewis BS, Musliner TA, Tershakovec AM, Lokhnygina Y, White JA, Reist C, McCagg A, Braunwald E.

Am Heart J. 2016 Dec;182:89-96. doi: 10.1016/j.ahj.2016.09.004.

PMID:
27914504
13.

PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the "Blueprint PD-L1 IHC Assay Comparison Project".

Hirsch FR, McElhinny A, Stanforth D, Ranger-Moore J, Jansson M, Kulangara K, Richardson W, Towne P, Hanks D, Vennapusa B, Mistry A, Kalamegham R, Averbuch S, Novotny J, Rubin E, Emancipator K, McCaffery I, Williams JA, Walker J, Longshore J, Tsao MS, Kerr KM.

J Thorac Oncol. 2016 Nov 29. pii: S1556-0864(16)33536-5. doi: 10.1016/j.jtho.2016.11.2228. [Epub ahead of print]

PMID:
27913228
16.

Metabotropic Glutamate Receptors, 5 years on.

Collingridge G, Manahan-Vaughan D, Nicoletti F, Schoepp D.

Neuropharmacology. 2016 Nov 28. pii: S0028-3908(16)30510-X. doi: 10.1016/j.neuropharm.2016.09.029. [Epub ahead of print] No abstract available.

PMID:
27908770
17.

A Simplified and Efficient Process for Insulin Production in Pichia pastoris.

Polez S, Origi D, Zahariev S, Guarnaccia C, Tisminetzky SG, Skoko N, Baralle M.

PLoS One. 2016 Dec 1;11(12):e0167207. doi: 10.1371/journal.pone.0167207.

18.

Development of a PCR Assay to Detect Low Level Trypanosoma cruzi in Blood Specimens Collected with PAXgene Blood DNA Tubes for Clinical Trials Treating Chagas Disease.

Wei B, Chen L, Kibukawa M, Kang J, Waskin H, Marton M.

PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005146. doi: 10.1371/journal.pntd.0005146.

19.

Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies.

Ross DS, Mehta K, Cabal A.

Bull Math Biol. 2016 Nov 30. [Epub ahead of print]

PMID:
27905067
20.

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase.

Tobias NJ, Ahrendt T, Schell U, Miltenberger M, Hilbi H, Bode HB.

PeerJ. 2016 Nov 24;4:e2720.

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