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Items: 1 to 20 of 15311

1.

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates.

Litou C, Vertzoni M, Xu W, Kesisoglou F, Reppas C.

Eur J Pharm Biopharm. 2017 Feb 15. pii: S0939-6411(16)30638-5. doi: 10.1016/j.ejpb.2017.02.009. [Epub ahead of print]

PMID:
28214603
2.

Cost-effectiveness of the 2014 U.S. Preventive Services Task Force (USPSTF) Recommendations for Intensive Behavioral Counseling Interventions for Adults With Cardiovascular Risk Factors.

Lin J, Zhuo X, Bardenheier B, Rolka DB, Gregg WE, Hong Y, Wang G, Albright A, Zhang P.

Diabetes Care. 2017 Feb 17. pii: dc161186. doi: 10.2337/dc16-1186. [Epub ahead of print]

PMID:
28213373
3.

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.

Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators..

N Engl J Med. 2017 Feb 17. doi: 10.1056/NEJMoa1613683. [Epub ahead of print]

PMID:
28212060
4.

Reduction of cyclophosphamide dose for patients with subset 2 low-risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.

Walterhouse DO, Pappo AS, Meza JL, Breneman JC, Hayes-Jordan A, Parham DM, Cripe TP, Anderson JR, Meyer WH, Hawkins DS.

Cancer. 2017 Feb 17. doi: 10.1002/cncr.30613. [Epub ahead of print]

PMID:
28211936
5.

Suboptimal achievement of low-density lipoprotein cholesterol targets in French patients with coronary heart disease. Contemporary data from the DYSIS II ACS/CHD study.

Ferrières J, Rouyer MV, Lautsch D, Ashton V, Ambegaonkar BM, Brudi P, Gitt AK; Dyslipidemia International Study (DYSIS) II France Study Group..

Arch Cardiovasc Dis. 2017 Feb 13. pii: S1875-2136(17)30020-7. doi: 10.1016/j.acvd.2016.11.004. [Epub ahead of print]

PMID:
28209375
6.

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M; Wellcome Trust Case Control Consortium., Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J; MORGAM Investigators., Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ, Schunkert H, Deloukas P, Kathiresan S; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators..

J Am Coll Cardiol. 2017 Feb 21;69(7):823-836. doi: 10.1016/j.jacc.2016.11.056.

PMID:
28209224
7.

Effect of gender and age on the relative bioavailability of doravirine: results of a Phase I trial in healthy subjects.

Behm MO, Yee KL, Fan L, Fackler P.

Antivir Ther. 2017 Feb 16. doi: 10.3851/IMP3142. [Epub ahead of print]

PMID:
28206979
8.

A highly pathogenic avian-derived influenza virus H5N1 with 2009 pandemic H1N1 internal genes demonstrates increased replication and transmission in pigs.

Abente EJ, Kitikoon P, Lager KM, Gauger PC, Anderson TK, Vincent AL.

J Gen Virol. 2017 Jan;98(1):18-30. doi: 10.1099/jgv.0.000678.

PMID:
28206909
9.

Eight Habits of Highly Effective Antimicrobial Stewardship Programs to Meet the Joint Commission Standards for Hospitals.

Goff DA, Kullar R, Bauer KA, File TM.

Clin Infect Dis. 2017 Feb 14. doi: 10.1093/cid/cix065. [Epub ahead of print] No abstract available.

PMID:
28203781
10.

Daptomycin for Complicated Skin Infections: A Randomized Trial.

Bradley J, Glasser C, Patino H, Arnold SR, Arrieta A, Congeni B, Daum RS, Kojaoghlanian T, Yoon M, Anastasiou D, Wolf DJ, Bokesch P.

Pediatrics. 2017 Feb 15. pii: e20162477. doi: 10.1542/peds.2016-2477. [Epub ahead of print]

PMID:
28202770
11.

Plasma Levels of Eicosapentaenoic Acid Are Associated with Anti-TNF Responsiveness in Rheumatoid Arthritis and Inhibit the Etanercept-driven Rise in Th17 Cell Differentiation in Vitro.

Jeffery L, Fisk HL, Calder PC, Filer A, Raza K, Buckley CD, McInnes I, Taylor PC, Fisher BA.

J Rheumatol. 2017 Feb 15. pii: jrheum.161068. doi: 10.3899/jrheum.161068. [Epub ahead of print]

PMID:
28202745
12.

A Phase II Study of a Human Anti-PDGFRα Monoclonal Antibody (Olaratumab, IMC-3G3) in Previously Treated Patients with Unresectable and/or Metastatic Gastrointestinal Stromal Tumors.

Wagner AJ, Kindler H, Gelderblom H, Schöffski P, Bauer S, Hohenberger P, Kopp HG, Lopez-Martin JA, Peeters M, Reichardt P, Qin A, Nippgen J, Ilaria RL, Rutkowski P.

Ann Oncol. 2017 Feb 14. doi: 10.1093/annonc/mdw659. [Epub ahead of print] No abstract available.

PMID:
28200030
13.

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice.

Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE.

Cell Rep. 2017 Feb 14;18(7):1606-1613. doi: 10.1016/j.celrep.2017.01.014.

PMID:
28199833
14.

Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve Biosimilar product quality.

Brühlmann D, Sokolov M, Butté A, Sauer M, Hemberger J, Souquet J, Broly H, Jordan M.

Biotechnol Bioeng. 2017 Feb 15. doi: 10.1002/bit.26269. [Epub ahead of print]

PMID:
28197999
15.

Erratum to: Efficacy and safety of aprepitant for the prevention of chemotherapy-induced nausea and vomiting during the first cycle of moderately emetogenic chemotherapy in Korean patients with a broad range of tumor types.

Kim JE, Jang JS, Kim JW, Lee SY, Cho CH, Lee MA, Kim DJ, Ahn MJ, Lee KY, Sym SJ, Lim MC, Jung H, Kim CE, Min KW.

Support Care Cancer. 2017 Feb 14. doi: 10.1007/s00520-017-3608-9. [Epub ahead of print] No abstract available.

PMID:
28197847
16.

Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.

Schröder M, Loos S, Naumann SK, Bachran C, Krötschel M, Umansky V, Helming L, Swee LK.

Oncoimmunology. 2016 Nov 29;6(1):e1258503. doi: 10.1080/2162402X.2016.1258503.

PMID:
28197378
17.

Design and Synthesis of Novel, Selective GPR40 AgoPAMs.

Plummer CW, Clements MJ, Chen H, Rajagopalan M, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Nolting AF, Orr R, Christensen M, Campeau LC, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Nargund R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2017 Jan 23;8(2):221-226. doi: 10.1021/acsmedchemlett.6b00443.

PMID:
28197316
18.

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ.

Proc Natl Acad Sci U S A. 2017 Feb 13. pii: 201616332. doi: 10.1073/pnas.1616332114. [Epub ahead of print]

19.

Evaluation of JAK3 biology in autoimmune disease using a highly selective, irreversible JAK3 inhibitor.

Elwood F, Witter D, Piesvaux J, Kraybill B, Bays N, Alpert C, Goldenblatt P, Qu Y, Ivanovska I, Lee HH, Chiu CS, Tang H, Scott ME, Deshmukh S, Zielstorff M, Byford A, Chakravarty K, Dorosh L, Rivkin A, Klappenbach J, Pan BS, Kariv I, Dinsmore C, Slipetz D, Dandliker P.

J Pharmacol Exp Ther. 2017 Feb 13. pii: jpet.116.239723. doi: 10.1124/jpet.116.239723. [Epub ahead of print]

20.

Safety and Efficacy of Elbasvir/Grazoprevir in Patients with Hepatitis C Virus Infection and Compensated Cirrhosis: an Integrated Analysis.

Jacobson IM, Lawitz E, Kwo PY, Hézode C, Peng CY, Howe AY, Hwang P, Wahl J, Robertson M, Barr E, Haber BA.

Gastroenterology. 2017 Feb 10. pii: S0016-5085(17)30150-6. doi: 10.1053/j.gastro.2017.01.050. [Epub ahead of print]

PMID:
28193518
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