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Items: 1 to 20 of 15212

1.

2D-LC as an on-line desalting tool allowing peptide identification directly from MS unfriendly HPLC methods.

Luo H, Zhong W, Yang J, Zhuang P, Meng F, Caldwell J, Mao B, Welch CJ.

J Pharm Biomed Anal. 2016 Nov 10;137:139-145. doi: 10.1016/j.jpba.2016.11.012. [Epub ahead of print]

PMID:
28113090
2.

Investigating the heterogeneity of alkylating agents' efficacy and toxicity between sexes: A systematic review and meta-analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study).

Fresneau B, Hackshaw A, Hawkins DS, Paulussen M, Anderson JR, Judson I, Litière S, Dirksen U, Lewis I, van den Berg H, Gaspar N, Gelderblom H, Whelan J, Boddy AV, Wheatley K, Pignon JP, De Vathaire F, Le Deley MC, Le Teuff G.

Pediatr Blood Cancer. 2017 Jan 23. doi: 10.1002/pbc.26457. [Epub ahead of print]

PMID:
28111876
3.

In Memoriam: Dr. Alexander D. Bain (1948-2016).

Martin G.

Magn Reson Chem. 2017 Jan 23. doi: 10.1002/mrc.4581. [Epub ahead of print] No abstract available.

PMID:
28111776
4.

The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.

Chobanian HR, Guo Y, Pio B, Tang H, Teumelsan N, Clements M, Frie J, Ferguson R, Guo Z, Thomas-Fowlkes BS, Felix JP, Liu J, Kohler M, Priest B, Hampton C, Pai LY, Corona A, Metzger J, Tong V, Joshi EM, Xu L, Owens K, Maloney K, Sullivan K, Pasternak A.

Bioorg Med Chem Lett. 2016 Oct 13. pii: S0960-894X(16)31060-5. doi: 10.1016/j.bmcl.2016.10.032. [Epub ahead of print]

PMID:
28111141
5.

A step-wise approach to define binding mechanisms of surrogate viral particles to multi-modal anion exchange resin in a single solute system.

Brown M, Johnson S, Brorson K, Lute S, Roush D.

Biotechnol Bioeng. 2017 Jan 21. doi: 10.1002/bit.26251. [Epub ahead of print]

PMID:
28109126
6.

Antibiotic-induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition.

Li Y, Hafey MJ, Duong H, Evers R, Cheon K, Holder DJ, Galijatovic-Idrizbegovic A, Sistare FD, Glaab WE.

Toxicol Sci. 2017 Jan 20. pii: kfx015. doi: 10.1093/toxsci/kfx015. [Epub ahead of print]

PMID:
28108666
7.

Real-time pH monitoring of industrially relevant enzymatic reactions in a microfluidic side-entry reactor (μSER) shows potential for pH control.

Gruber P, Marques MP, Sulzer P, Wohlgemuth R, Mayr T, Baganz F, Szita N.

Biotechnol J. 2017 Jan 20. doi: 10.1002/biot.201600475. [Epub ahead of print]

PMID:
28106351
8.

Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing.

Schmiegel W, Scott RJ, Dooley S, Lewis W, Meldrum CJ, Pockney P, Draganic B, Smith S, Hewitt C, Philimore H, Lucas A, Shi E, Namdarian K, Chan T, Acosta D, Ping-Chang S, Tannapfel A, Reinacher-Schick A, Uhl W, Teschendorf C, Wolters H, Stern J, Viebahn R, Friess H, Janssen KP, Nitsche U, Slotta-Huspenina J, Pohl M, Vangala D, Baraniskin A, Dockhorn-Dworniczak B, Hegewisch-Becker S, Ronga P, Edelstein DL, Jones FS, Hahn S, Fox SB.

Mol Oncol. 2016 Nov 16. doi: 10.1002/1878-0261.12023. [Epub ahead of print]

9.

Limitations of polyethylene glycol-induced precipitation as predictive tool for protein solubility during formulation development.

Hofmann M, Winzer M, Weber C, Gieseler H.

J Pharm Pharmacol. 2017 Jan 20. doi: 10.1111/jphp.12699. [Epub ahead of print]

PMID:
28106257
10.

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

Petrilli WL, Hoyt SB, London C, McMasters D, Verras A, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Chen Q, Li Y, Tung E, Tang W, Salituro G, Knemeyer I, Karanam B, Clemas J, Zhou G, Gibson J, Shipley CA, MacNeil DJ, Duffy R, Tata JR, Ujjainwalla F, Ali A, Xiong Y.

ACS Med Chem Lett. 2016 Nov 22;8(1):128-132. doi: 10.1021/acsmedchemlett.6b00455.

PMID:
28105288
11.

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents.

Adams GL, Velazquez F, Jayne C, Shah U, Miao S, Ashley ER, Madeira M, Akiyama TE, Di Salvo J, Suzuki T, Wang N, Truong Q, Gilbert E, Zhou D, Verras A, Kirkland M, Pachanski M, Powles M, Yin W, Ujjainwalla F, Venkatraman S, Edmondson SD.

ACS Med Chem Lett. 2016 Dec 6;8(1):96-101. doi: 10.1021/acsmedchemlett.6b00394.

PMID:
28105282
12.

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.

Cox JM, Chu HD, Chelliah MV, Debenham JS, Eagen K, Lan P, Lombardo M, London C, Plotkin MA, Shah U, Sun Z, Vaccaro HM, Venkatraman S, Suzuki T, Wang N, Ashley ER, Crespo A, Madeira M, Leung DH, Alleyne C, Ogawa AM, Souza S, Thomas-Fowlkes B, Di Salvo J, Weinglass A, Kirkland M, Pachanski M, Powles MA, Tozzo E, Akiyama TE, Ujjainwalla F, Tata JR, Sinz CJ.

ACS Med Chem Lett. 2016 Nov 17;8(1):49-54. doi: 10.1021/acsmedchemlett.6b00360.

PMID:
28105274
13.

Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation.

Corcoran K, Sherrod CJ, Perkowski EF, Texier J, Li F, Wang IM, McVoy M, Fu TM, Dittmer DP.

Genome Announc. 2017 Jan 19;5(3). pii: e01433-16. doi: 10.1128/genomeA.01433-16.

14.

A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling canine flea infestations.

Meadows C, Guerino F, Sun F.

Parasit Vectors. 2017 Jan 19;10(1):36. doi: 10.1186/s13071-017-1971-5.

15.

A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling feline flea infestations.

Meadows C, Guerino F, Sun F.

Parasit Vectors. 2017 Jan 19;10(1):37. doi: 10.1186/s13071-017-1972-4.

16.

Mechanistic Study of the Gas-Phase In-Source Hofmann Elimination of Doubly Quaternized Cinchona-Alkaloid Based Phase-Transfer Catalysts by (+)-Electrospray Ionization/Tandem Mass Spectrometry.

Yang RS, Sheng H, Lexa KW, Sherer EC, Zhang LK, Xiang B, Helmy R, Mao B.

J Am Soc Mass Spectrom. 2017 Jan 18. doi: 10.1007/s13361-016-1583-x. [Epub ahead of print]

PMID:
28101849
17.

Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies.

Rampakakis E, Stutz M, Kawai K, Tsai TF, Cheong HJ, Dhitavat J, Ortiz-Covarrubias A, Cashat-Cruz M, Monsanto H, Johnson KD, Sampalis JS, Acosta CJ.

Health Qual Life Outcomes. 2017 Jan 18;15(1):11. doi: 10.1186/s12955-017-0588-x.

18.

Assessment of coulometric array electrochemical detection coupled with HPLC-UV for the absolute quantitation of pharmaceuticals.

Hicks MB, Salituro L, Mangion I, Schafer W, Xiang R, Gong X, Welch CJ.

Analyst. 2017 Jan 18. doi: 10.1039/c6an02432g. [Epub ahead of print]

PMID:
28098264
19.

Erratum to: Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling.

Tiwari A, Abraham AK, Harrold JM, Zutshi A, Singh P.

AAPS J. 2017 Jan 17. doi: 10.1208/s12248-017-0046-z. [Epub ahead of print] No abstract available.

PMID:
28097628
20.

Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.

Gotta V, Yu Z, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH.

Pharmacol Res Perspect. 2016 Nov 17;4(6):e00270. doi: 10.1002/prp2.270.

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