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The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M.

Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051.


Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2.

Al Taleb Z, Petry A, Chi TF, Mennerich D, Görlach A, Dimova EY, Kietzmann T.

J Mol Med (Berl). 2016 Oct;94(10):1153-1166. Epub 2016 Jun 10.


Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity.

Kietzmann T, Mennerich D, Dimova EY.

Front Cell Dev Biol. 2016 Feb 23;4:11. doi: 10.3389/fcell.2016.00011. eCollection 2016. Review.


PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M.

EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492.


Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor.

Saha SS, Singh D, Raymond EL, Ganesan R, Caviness G, Grimaldi C, Woska JR Jr, Mennerich D, Brown SE, Mbow ML, Kao CC.

J Biol Chem. 2015 Sep 25;290(39):23997-4006. doi: 10.1074/jbc.M115.653378. Epub 2015 Aug 12.


Antioxidant responses and cellular adjustments to oxidative stress.

Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S, Lamas S.

Redox Biol. 2015 Dec;6:183-97. doi: 10.1016/j.redox.2015.07.008. Epub 2015 Jul 21. Review.


The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential.

Antonenkov VD, Isomursu A, Mennerich D, Vapola MH, Weiher H, Kietzmann T, Hiltunen JK.

J Biol Chem. 2015 May 29;290(22):13840-61. doi: 10.1074/jbc.M114.608083. Epub 2015 Apr 10.


Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors.

Uhrig-Schmidt S, Geiger M, Luippold G, Birk G, Mennerich D, Neubauer H, Grimm D, Wolfrum C, Kreuz S.

PLoS One. 2014 Dec 31;9(12):e116288. doi: 10.1371/journal.pone.0116288. eCollection 2014.


Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β.

Mennerich D, Dimova EY, Kietzmann T.

Hypoxia (Auckl). 2014 Apr 30;2:35-45. eCollection 2014. Review.


Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence.

Samoylenko A, Hossain JA, Mennerich D, Kellokumpu S, Hiltunen JK, Kietzmann T.

Antioxid Redox Signal. 2013 Dec 10;19(17):2157-96. doi: 10.1089/ars.2012.4662. Epub 2013 Apr 15. Review.


Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human.

Birzele F, Fauti T, Stahl H, Lenter MC, Simon E, Knebel D, Weith A, Hildebrandt T, Mennerich D.

Nucleic Acids Res. 2011 Oct;39(18):7946-60. doi: 10.1093/nar/gkr444. Epub 2011 Jul 4.


Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.

Schulz C, Paus M, Frey K, Schmid R, Kohl Z, Mennerich D, Winkler J, Gillardon F.

PLoS One. 2011;6(6):e20820. doi: 10.1371/journal.pone.0020820. Epub 2011 Jun 9.


Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.

Baum P, Schmid R, Ittrich C, Rust W, Fundel-Clemens K, Siewert S, Baur M, Mara L, Gruenbaum L, Heckel A, Eils R, Kontermann RE, Roth GJ, Gantner F, Schnapp A, Park JE, Weith A, Quast K, Mennerich D.

PLoS One. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272.


Comparison of normalization methods for Illumina BeadChip HumanHT-12 v3.

Schmid R, Baum P, Ittrich C, Fundel-Clemens K, Huber W, Brors B, Eils R, Weith A, Mennerich D, Quast K.

BMC Genomics. 2010 Jun 2;11:349. doi: 10.1186/1471-2164-11-349.


Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, Castagne R, Maouche S, Germain M, Lackner K, Rossmann H, Eleftheriadis M, Sinning CR, Schnabel RB, Lubos E, Mennerich D, Rust W, Perret C, Proust C, Nicaud V, Loscalzo J, Hübner N, Tregouet D, Münzel T, Ziegler A, Tiret L, Blankenberg S, Cambien F.

PLoS One. 2010 May 18;5(5):e10693. doi: 10.1371/journal.pone.0010693.


miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression.

Stahl HF, Fauti T, Ullrich N, Bopp T, Kubach J, Rust W, Labhart P, Alexiadis V, Becker C, Hafner M, Weith A, Lenter MC, Jonuleit H, Schmitt E, Mennerich D.

PLoS One. 2009 Sep 24;4(9):e7158. doi: 10.1371/journal.pone.0007158.


An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types.

Staub E, Groene J, Heinze M, Mennerich D, Roepcke S, Klaman I, Hinzmann B, Castanos-Velez E, Pilarsky C, Mann B, Brümmendorf T, Weber B, Buhr HJ, Rosenthal A.

J Mol Med (Berl). 2009 Jun;87(6):633-44. doi: 10.1007/s00109-009-0467-y. Epub 2009 Apr 28.


Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues.

Popova T, Mennerich D, Weith A, Quast K.

BMC Genomics. 2008 Feb 25;9:91. doi: 10.1186/1471-2164-9-91.


Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors.

Staub E, Groene J, Heinze M, Mennerich D, Roepcke S, Klaman I, Hinzmann B, Castanos-Velez E, Pilarsky C, Mann B, Brümmendorf T, Weber B, Buhr HJ, Rosenthal A.

Mol Cancer. 2007 Dec 14;6:79.


Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway.

Kasper G, Reule M, Tschirschmann M, Dankert N, Stout-Weider K, Lauster R, Schrock E, Mennerich D, Duda GN, Lehmann KE.

BMC Cancer. 2007 Jan 17;7:12.

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