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Fertil Steril. 1996 Jun;65(6):1253-5.

Memory complaints associated with the use of gonadotropin-releasing hormone agonists: a preliminary study.

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1
Department of Psychology, University Hospital, London, Ontario, Canada.

Abstract

OBJECTIVES:

To study the effect of GnRH agonist (GnRH-a) treatment on memory and to assess the role of psychological factors.

DESIGN:

A randomized prospective study.

SETTING:

An academic teaching hospital.

PARTICIPANTS:

Women with endometriosis and infertility or endometriosis alone.

MAIN OUTCOME MEASURES:

Memory Observation Questionnaire, Profile of Mood States, Health Concerns scale, a weekly diary of adverse effects.

RESULTS:

Perceived memory functioning decreased during GnRH-a administration and by the final week of treatment 44% of women reported moderate to marked impairment in comparison to community norms. Prospective memory was most affected and withdrawal of GnRH-a treatment resulted in a return to normal memory functioning. Impairment was not related to excessive health concerns or mood changes and was uncorrelated with other adverse effects.

CONCLUSIONS:

Memory disruption may be a more common side effect of GnRH-a treatment than currently is recognized. Problems were temporary and more likely a result of rapid estrogen depletion than a consequence of mood, somatic distress, or personality factors.

PMID:
8641510
[Indexed for MEDLINE]

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